A5100352475- Colorectal Cancer Surgical Treatments
- Gastric Cancer Management and Outcomes
- Colorectal and Anal Carcinomas
- Cancer-related molecular mechanisms research
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Screening and Detection
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Lung Cancer Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Lipid metabolism and disorders
- Metastasis and carcinoma case studies
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- RNA regulation and disease
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastrointestinal Tumor Research and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Molecular Biology Techniques and Applications
Fudan University Shanghai Cancer Center
2010-2025
Shanghai Medical College of Fudan University
2017-2025
Shanghai Clinical Research Center
2022-2025
Tangshan People's Hospital
2020-2025
Chengdu University of Traditional Chinese Medicine
2025
Yuhuangding Hospital
2023-2025
Qingdao University
2022-2025
Capital Medical University
2023-2025
Shanghai Institute of Hematology
2021-2024
Peking University Cancer Hospital
2017-2024
The gut microbiome is involved in antitumor immunotherapy and chemotherapy responses; however, evidence-based research on the role of predicting response to neoadjuvant chemoradiotherapy (nCRT) patients with locally advanced rectal cancer (LARC) remains scarce. This prospective, longitudinal study aimed evaluate feasibility nCRT responses.We collected 167 fecal samples from 84 LARC before after 31 specimens healthy individuals for 16S rRNA sequencing. Patients were divided into responders...
For locally advanced rectal cancer (LARC) patients who receive neoadjuvant chemoradiotherapy (nCRT), there are no reliable indicators to accurately predict pathological complete response (pCR) before surgery. with clinical (cCR), a "Watch and Wait" (W&W) approach can be adopted improve quality of life. However, W&W may increase the recurrence risk in judged cCR but have minimal residual disease (MRD). Magnetic resonance imaging (MRI) is major tool evaluate nCRT; however, its ability pCR...
PURPOSE To assess whether the integration of PD-1 inhibitor with total neoadjuvant therapy (iTNT) can lead to an improvement in complete responses (CRs) and favors a watch-and-wait (WW) strategy patients proficient mismatch repair or microsatellite stable (pMMR/MSS) locally advanced rectal cancer (LARC). PATIENTS AND METHODS We conducted prospective, multicenter, randomized, open-label, phase II trial using pick-the-winner design. Eligible clinical T3-4 and/or N+ adenocarcinoma were randomly...
Depression is a serious and potentially life-threatening mental disorder with unknown etiology. Emerging evidence shows that brain-derived neurotrophic factor (BDNF) microRNAs (miRNAs) play critical roles in the etiology of depression. Here this study was aimed to identify characterize BDNF its putative regulatory miRNAs First, we identified miR-182 may be miRNA regulates levels by bioinformatic studies, characterized effects on using cell-based side miR-132 (a known expression). We showed...
Abstract Background For patients with locally advanced (T3-4/N +) rectal cancer (LARC), the standard treatment is neoadjuvant chemoradiotherapy combined total mesorectal resection, which greatly decreases local recurrence but does not improve overall survival. who achieve a complete clinical response (cCR) after nCRT, “Watch & Wait” (W&W) approach can be received to quality of life. Currently, therapy (TNT) has been demonstrated increase rate and early control distant metastasis....
Abstract The proteins involved in breast cancer initiation and progression are still largely elusive. To gain insights into these processes, we conducted quantitative proteomic analyses with 21T series of cell lines, which include a normal, primary tumor metastatic that were isolated from single patient. Stable isotope labeling amino acid culture followed by LC‐MS/MS analysis was performed deregulated identified using statistical analysis. Gene ontology revealed metabolic processes the most...
Several studies have demonstrated that the isolated side population (SP) cells from solid tumors exhibit cancer stem cell‑like properties, and are responsible for drug resistance during chemotherapy tumor recurrence. In current study, SP were in MDU‑22 breast cell line using Hoechst‑33342 dye exclusion technique. It was observed accounted 3.8% of line, which reduced to 0.6% presence verapamil, an inhibitor ABC transporter. The sorted showed elevated expression markers, including ABCG2, OCT‑4...
Three new tyramine-type alkamides (1–3), three natural products (4–6), five N-acylated/formylated aporphine with different ratios of rotational isomers (7–11), and 20 known (12–31) were isolated from an EtOH extract the stems leaves Piper puberulum. The absolute configurations compounds 7, 8, 10 determined by single-crystal X-ray diffraction analysis. In biological activity assay, 3, 5, 10–23 displayed inhibitory effects against lipopolysaccharide-induced NO release in BV-2 microglial cells,...
The most devastating and catastrophic deterioration of myocardial ischemia-reperfusion injury (MIRI) is cardiomyocyte death. Here we aimed to evaluate the role lncRNA-ZFAS1 in MIRI delineate its mechanism action. level was elevated hearts, artificial knockdown mice improved cardiac function. Notch1 a potential target lncRNA-ZFAS1, could bind promoter region recruit DNMT3b induce methylation. Nicotinamide mononucleotide promote expression by competitively inhibiting improving apoptosis cardiomyocytes
Abstract Adding irinotecan to neoadjuvant chemoradiotherapy (nCRT) in locally advanced rectal cancer (LARC) increases the pathologic complete response (pCR) rate but brings more toxicities. Robust biomarkers predict irinotecan‐based nCRT are extremely necessary for selecting right patients. Our previous study suggests that patient‐derived tumor organoids (PDTOs) sensitivity matches patient responses. In this study, we investigated whether PDTOs can (CR) and survival. Eligible patients...
A "Watch and Wait" (W&W) approach has become an alternative to surgery for locally advanced rectal cancer (LARC) after neoadjuvant chemoradiotherapy (nCRT). Precise prediction of pathological complete response (pCR) will improve patient selection W&W. We investigated the utility cell-free DNA (cfDNA) fragmentomics in predicting pCR.We recruited 119 LARC patients evaluated nCRT by pCR status or MRI tumor regression grade (mrTRG). Plasma samples before, during, were applied deep targeted-panel...
Abstract Background Delirium is common among elderly patients in the intensive care unit (ICU) and associated with prolonged hospitalization, increased healthcare costs, risk of death. Understanding potential factors early prevention delirium critical to facilitate timely intervention that may reverse or mitigate harmful consequences delirium. Aim To clarify effects pre-admission falls on ICU outcomes, primarily delirium, secondarily pressure injuries urinary tract infections. Methods The...
Irinotecan, an analog of camptothecin, which is inhibitor topoisomerase I, currently used in the treatment metastatic colorectal cancer. Camptothecin derivatives have been demonstrated to exert radiosensitizing effects on several types cancer cells. However, date, at least best our knowledge, few studies examined these cell lines. In present study, we irinotecan p53-mutant lines, HT29 and SW620, explored potential underlying mechanisms. Drug cytotoxicity tests revealed that 24 h half-maximal...
Tumor deposit (TD) was associated with poor survival in colorectal cancer. However, its prognostic and staging value locally advanced rectal cancer (LARC) patients following neoadjuvant chemoradiotherapy (neo-CRT) is controversial. Four hundred ninety-five LARC neo-CRT surgery were retrospectively analyzed. Univariate multivariate analyses performed using Kaplan-Meier method Cox proportional hazards regression all lymph node (LN) -negative LN-positive patients. Next, we used three methods to...
Purpose Abnormal expression of PINCH-1 has been observed in various types human cancers. However, the clinical importance and mechanism underlying its role head neck squamous cell carcinoma (HNSCC) is yet to be fully elucidated.
Abstract Background Radiotherapy (RT) is an essential treatment for colorectal cancer (CRC), yet the factors influencing radiosensitivity remain unclear. In quest to enhance therapeutic efficacy in CRC, interplay between genetic mutations and RT sensitivity has emerged as a pivotal enigmatic area. Methods We harness fidelity of patient-derived organoids (PDOs) dissect molecular landscape radiosensitivity, with particular emphasis on BRAF V600E mutations. To further investigate, cohort 9...