A5101583153- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Colorectal Cancer Treatments and Studies
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Advanced Radiotherapy Techniques
- Genetic factors in colorectal cancer
- Nutrition and Health in Aging
- Esophageal Cancer Research and Treatment
- Microbial Metabolites in Food Biotechnology
- Polysaccharides and Plant Cell Walls
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Metastasis and carcinoma case studies
- Probiotics and Fermented Foods
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Gut microbiota and health
- Lung Cancer Treatments and Mutations
- Proteoglycans and glycosaminoglycans research
- Medical Imaging Techniques and Applications
- Cancer Immunotherapy and Biomarkers
- Gastrointestinal Tumor Research and Treatment
Nanjing Agricultural University
2019-2025
Fudan University Shanghai Cancer Center
2016-2025
Shanghai Medical College of Fudan University
2008-2025
Shanghai Clinical Research Center
2022-2025
Hefei Institutes of Physical Science
2025
Chinese Academy of Sciences
2025
Shanghai Institute of Hematology
2021-2024
Jinzhou Medical University
2024
China University of Geosciences
2024
First Affiliated Hospital of Soochow University
2023
The gut microbiome is involved in antitumor immunotherapy and chemotherapy responses; however, evidence-based research on the role of predicting response to neoadjuvant chemoradiotherapy (nCRT) patients with locally advanced rectal cancer (LARC) remains scarce. This prospective, longitudinal study aimed evaluate feasibility nCRT responses.We collected 167 fecal samples from 84 LARC before after 31 specimens healthy individuals for 16S rRNA sequencing. Patients were divided into responders...
For locally advanced rectal cancer (LARC) patients who receive neoadjuvant chemoradiotherapy (nCRT), there are no reliable indicators to accurately predict pathological complete response (pCR) before surgery. with clinical (cCR), a "Watch and Wait" (W&W) approach can be adopted improve quality of life. However, W&W may increase the recurrence risk in judged cCR but have minimal residual disease (MRD). Magnetic resonance imaging (MRI) is major tool evaluate nCRT; however, its ability pCR...
Differentiating the irinotecan dose on basis of uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) genotype improves pathologic complete response (pCR) rate. In this study, we further investigated preoperative combined with capecitabine-based chemoradiotherapy for locally advanced rectal cancer.We conducted randomized, open-label, multicenter, phase III trial in China. Eligible patients clinical T3-4 and/or N+ adenocarcinoma, UGT1A1 *1*1 or *1*28 were randomly allocated to control...
PURPOSE To assess whether the integration of PD-1 inhibitor with total neoadjuvant therapy (iTNT) can lead to an improvement in complete responses (CRs) and favors a watch-and-wait (WW) strategy patients proficient mismatch repair or microsatellite stable (pMMR/MSS) locally advanced rectal cancer (LARC). PATIENTS AND METHODS We conducted prospective, multicenter, randomized, open-label, phase II trial using pick-the-winner design. Eligible clinical T3-4 and/or N+ adenocarcinoma were randomly...
Recent studies have shown that magnetic resonance (MR) radiomic analysis is feasible and has some value in identifying tumor characteristics, but there are few data regarding the role of MR-based features rectal cancer.
Abstract Background For patients with locally advanced (T3-4/N +) rectal cancer (LARC), the standard treatment is neoadjuvant chemoradiotherapy combined total mesorectal resection, which greatly decreases local recurrence but does not improve overall survival. who achieve a complete clinical response (cCR) after nCRT, “Watch & Wait” (W&W) approach can be received to quality of life. Currently, therapy (TNT) has been demonstrated increase rate and early control distant metastasis....
Abstract Adding irinotecan to neoadjuvant chemoradiotherapy (nCRT) in locally advanced rectal cancer (LARC) increases the pathologic complete response (pCR) rate but brings more toxicities. Robust biomarkers predict irinotecan‐based nCRT are extremely necessary for selecting right patients. Our previous study suggests that patient‐derived tumor organoids (PDTOs) sensitivity matches patient responses. In this study, we investigated whether PDTOs can (CR) and survival. Eligible patients...
A "Watch and Wait" (W&W) approach has become an alternative to surgery for locally advanced rectal cancer (LARC) after neoadjuvant chemoradiotherapy (nCRT). Precise prediction of pathological complete response (pCR) will improve patient selection W&W. We investigated the utility cell-free DNA (cfDNA) fragmentomics in predicting pCR.We recruited 119 LARC patients evaluated nCRT by pCR status or MRI tumor regression grade (mrTRG). Plasma samples before, during, were applied deep targeted-panel...
Abstract The fusion genes NRG1 and NRG2, members of the epidermal growth factor (EGF) receptor family, have emerged as key drivers in cancer. Upon fusion, retains its EGF-like active domain, binds to ERBB ligand triggers intracellular signaling cascades, promoting uncontrolled cell proliferation. incidence gene varies across cancer types, with lung being most prevalent at 0.19 0.27%. CD74 SLC3A2 are frequently observed partners. RNA-based next-generation sequencing is primary method for...
Heparin (Hep), widely used in clinics as an anticoagulant drug, has high degrees of heterogeneity and shares a similar disaccharide repeating unit with its GAG analogues. The development reliable convenient methods to discriminate Hep from analogues detect trace contaminants is meaningful for safe usage clinics. Herein, five porphyrin-GO nanocomposites denoted PP1-GO, PP2a-GO, PP2b-GO, PP3-GO, PP4-GO were synthesized by assembling corresponding positively charged porphyrins onto the surface...
LHEPS-1 exhibited the strongest anti-proliferation effect, prevented G<sub>1</sub> to S transition and increased apoptosis of human colon cancer HT-29 cells.
Abstract Background Radiotherapy (RT) is an essential treatment for colorectal cancer (CRC), yet the factors influencing radiosensitivity remain unclear. In quest to enhance therapeutic efficacy in CRC, interplay between genetic mutations and RT sensitivity has emerged as a pivotal enigmatic area. Methods We harness fidelity of patient-derived organoids (PDOs) dissect molecular landscape radiosensitivity, with particular emphasis on BRAF V600E mutations. To further investigate, cohort 9...
Abstract Background: Total neoadjuvant therapy (TNT) combined with immunotherapy (iTNT) has shown promising results for locally advanced rectal cancer (LARC), especially in proficient mismatch repair (pMMR)/microsatellite stable (MSS) patients. However, traditional clinical approaches often fail to accurately forecast outcomes, and reliable methods predict treatment response recurrence risk are essential optimizing strategies maximizing organ preservation. Methods: We analyzed genetic data...
Family members play a central supporting role in cancer patient management. This study aimed to assess the knowledge, attitudes, and practices (KAP) of patients' family regarding use integrative Chinese-Western medicine treatment. Proper knowledge is necessary for informed decision-making providing adequate care support. cross-sectional was conducted between August 2022 December included patients. A total 493 questionnaires were collected. The mean score 5.87 ± 3.63 (possible range: 0-12),...