A5016028345- Energetic Materials and Combustion
- Colorectal and Anal Carcinomas
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Treatments and Studies
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Thermal and Kinetic Analysis
- Ionic liquids properties and applications
- Cancer-related molecular mechanisms research
- Food composition and properties
- Structural Engineering and Vibration Analysis
- Geomechanics and Mining Engineering
- Inorganic and Organometallic Chemistry
- Polysaccharides Composition and Applications
- Soil, Finite Element Methods
- Gas Sensing Nanomaterials and Sensors
- MicroRNA in disease regulation
- Proteins in Food Systems
- RNA modifications and cancer
- Civil and Geotechnical Engineering Research
- Cancer Mechanisms and Therapy
- Optical measurement and interference techniques
- Entomopathogenic Microorganisms in Pest Control
- Wnt/β-catenin signaling in development and cancer
- Material Properties and Applications
Jilin Medical University
2025
Jilin University
2025
Mudanjiang Normal University
2023-2024
Harbin University of Commerce
2023-2024
China Academy of Engineering Physics
2017-2022
Liaoning Cancer Hospital & Institute
2016-2021
China Medical University
2020-2021
North University of China
2017
Hebei University of Engineering
2009-2012
Institute of Physics
2012
Differentiating the irinotecan dose on basis of uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) genotype improves pathologic complete response (pCR) rate. In this study, we further investigated preoperative combined with capecitabine-based chemoradiotherapy for locally advanced rectal cancer.We conducted randomized, open-label, multicenter, phase III trial in China. Eligible patients clinical T3-4 and/or N+ adenocarcinoma, UGT1A1 *1*1 or *1*28 were randomly allocated to control...
Modern pharmacological research has revealed that andrographolide various functions, including anti-bacterial, anti-inflammatory and anti-viral effects, immunoregulation, treating cardiovascular cerebrovascular diseases, prevention treatment of alcoholic liver injury. The present study investigated whether suppresses the proliferation human colon cancer cell through Toll-like receptor 4 (TLR4)/nuclear factor (NF)-κB/matrix metalloproteinase-9 (MMP-9) signaling pathway. MTT assay lactate...
The crystal structure transformation and step-by-step thermal decomposition behavior of dihydroxylammonium 5,5′-bistetrazole-1,1′-diolate (TKX-50) under stimulation were studied.
Zinc metal is an attractive anode material of aqueous batteries, but its practical use persistently hampered by irregular zinc electrodeposition/dissolution and parasitic side reactions. Here we report engineering copper-zinc alloy with a composition- structure-gradient nanoporous architecture as effective strategy to regulate high-efficiency dendrite-free for high-performance zinc-ion batteries. The dual-gradient electrodes not only guarantee electron ion transport pathways work host...
The microstructure and performance of HMX were adjusted by a solvation-desolvation process. solvates prepared recrystallization in N,N-dimethylformamide (DMF) N-methylpyrrolidone (NMP), respectively. Specific microstructures with microcrystal clusters obtained the desolvation through anti-solvent extraction vacuum pyrolysis. With different solvents methods, crystals show variety morphologies, particle size, polymorphic stability. microcrystalline can be easily broken into superfine...
It has been reported that lncRNA DSCAM-AS1 plays an oncogenic role in breast cancer. In the present study we explored of colorectal adenocarcinoma (CRA).Methods: Gene expression was analyzed by qPCR and Western blot. Overexpression experiments were performed to analyze gene interactions. Transwell assays cell invasion migration. Methylation-specific PCR (MSP) DNA methylation.It observed upregulated primary tumor tissues than paired non-tumor (within 2 cm around tumors) further increased with...
The methylation at position N6 of adenine is called N6-methyladenosine (m6A). This transcriptional RNA modification exerts a very active and important role in metabolism other biological processes. However, the activities m6A associated with malignant liver hepatocellular carcinoma (LIHC) are unknown worthy study. Using data University California, Santa Cruz (UCSC), expression M6A regulators pan-cancer was evaluated as screening approach to identify association gene 18 cancer types, specific...
3510 Background: Our phase I/II study identified irinotecan dose differentiated by UGT1A1 genotype in the neoadjuvant CRT and showed improved pCR. The objective of this III was to further investigate combined with capecitabine-based chemoradiotherapy as preoperative treatment for locally advanced rectal cancer. Methods: We underwent a prospective, randomized, open-label, multicenter, 3 trial China from Nov.2015 Dec.2017. Eligible patients clinical stage T3-4 and/or N+ adenocarcinoma were...
Abstract The stability of solid TKX‐50 has attracted considerable attention. However, the in solvents not been investigated sufficiently yet. Herein, various solvents, including N, N‐dimethylformamide (DMF), dimethyl sulfoxide (DMSO), acetone, deionized water, ethyl acetate, acetonitrile, methanol, ethanol, petroleum ether, hexane, DMF/acetone (mixture DMF and acetone) DMF/DMSO DMSO), studied. results show that remains stable DMSO, ether hexane. It is remarkable can react with different ways...
Rice starch-hydrophilic colloid complexes (SHCs) were prepared by incorporating xanthan gum and locust bean into natural rice starch. Subsequently, they underwent hygrothermal treatment (H-SHC) to investigate their structural digestive properties with varying types added amounts of H-SHC. The results demonstrated that heat–moisture (HMT) led an increase in resistant starch (RS) content This effect was more pronounced after the addition hydrophilic colloid, causing RS surge from 8.42 ± 0.39%...
TPS3632 Background: Irinotecan is an effective drug for rectal cancer. Early small sample size trials have assessed the addition of irinotecan to standard CRT with fluoropyrimidines in neoadjuvant phase locally advanced cancer, which pCR rates varied from 13.7 37%. ARISTOTLE trial, a multicentre UK-based III will complete recruitment autumn 2016. However, all patients case group were prescribed weekly dose 60mg/m 2 guided by UGT1A1*28 6/6 and 6/7 genetypes chemoradiation. Therefore, this...
3603 Background: Adding UGT1A1-guided irinotecan to capecitabine-based neoadjuvant chemoradiotherapy (CRT) significantly increased the pathological complete response (pCR) rate nearly doubling [J Clin Oncol. 2020 Dec 20;38(36):4231-4239]. Here, results of long-term outcome are reported. Methods: Eligible patients with clinical stage II/III rectal adenocarcinoma, UGT1A1 genotype *1*1 or *1*28 were randomized control group: pelvic radiation 50 Gy/25 fractions concurrent capecitabine, followed...