A5100676881- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Lung Cancer Research Studies
- Cancer-related molecular mechanisms research
- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- MicroRNA in disease regulation
- Chromatin Remodeling and Cancer
- Lung Cancer Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Genetic factors in colorectal cancer
- Cancer Cells and Metastasis
- HER2/EGFR in Cancer Research
- Circular RNAs in diseases
- Cancer Diagnosis and Treatment
- Inflammasome and immune disorders
- Gastric Cancer Management and Outcomes
- Metabolomics and Mass Spectrometry Studies
- Liver physiology and pathology
- Hepatocellular Carcinoma Treatment and Prognosis
Ministry of Water Resources of the People's Republic of China
2025
Ministry of Natural Resources
2023-2025
Xuzhou Medical College
2022-2025
The First People’s Hospital of Lianyungang
2022-2025
Inner Mongolia Medical University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
East China University of Science and Technology
2024
Shanxi Medical University
2019-2024
Zhengzhou People's Hospital
2012-2024
Ministry of Education of the People's Republic of China
2011-2024
Significance In a few milliliters of blood from cancer patient, one can isolate circulating tumor cells (CTCs). Originating the primary tumor, CTCs seed metastases, which account for majority cancer-related deaths. We demonstrate analyses whole genome single CTCs, are highly needed personalized treatment. discovered that copy number variations (CNVs), major genomic variations, specific to types, reproducible cell cell, and even patient patient. hypothesize CNVs at certain loci selected lead...
Purpose Mutations in the epidermal growth factor receptor (EGFR) kinase domain can predict tumor response to tyrosine inhibitors (TKIs) non–small-cell lung cancer (NSCLC). However, obtaining tissues for mutation analysis is challenging. We hypothesized that plasma-based EGFR feasible and has value predicting patients with NSCLC. Patients Methods Plasma DNA samples matched tumors from 230 stages IIIB IV NSCLC were analyzed mutations exons 19 21 by using denaturing high-performance liquid...
EGFR mutation is a predictor of epidermal growth factor receptor-tyrosine kinase inhibitor treatment response in patients with non-small-cell lung cancer (NSCLC). However, it remains unclear whether chemotherapy affects status NSCLC. We investigated the influence on mutations plasma and tumor tissues from NSCLC.Samples were derived three cohorts: one, 264 advanced NSCLC who received first-line matched pre- postchemotherapy blood samples; two, 63 stages IIb to IIIb disease post-neoadjuvant...
Osteosarcoma is the most common primary bone malignancy, and lung frequent site of metastasis. The limited understanding tumoral heterogeneity evolutionary process genomic alterations in pulmonary metastatic osteosarcoma impedes development novel therapeutic strategies. Here we systematically illustrate disparities between tumors corresponding by multiregional whole-exome whole-genome sequencing 86 tumor regions from 10 patients with osteosarcoma. Metastatic exhibited a significantly higher...
Background Among advanced non-small cell lung cancer (NSCLC) patients with an acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKI), about 50% carry the T790M mutation, but this frequency in EGFR-TKI-naïve and dynamic change during therapy remains unclear. This study investigated quantification of mutation plasma cell-free DNA (cf-DNA) NSCLC assess clinical outcomes EGFR-TKI therapy. Materials Methods We retrospectively 135 who obtained...
Lung cancer, one of the most common malignant tumors, exhibits high inter- and intra-tumor heterogeneity which contributes significantly to treatment resistance failure. Single-cell RNA sequencing (scRNA-seq) has been widely used dissect cellular composition characterize molecular properties cancer cells their tumor microenvironment in lung cancer. However, transcriptomic among various non-small cell (NSCLC) warrants further illustration.To comprehensively analyze NSCLC, we performed...
Immunophenotyping of the tumor microenvironment (TME) is essential for enhancing immunotherapy efficacy. However, strategies characterizing TME exhibit significant heterogeneity. Here, we show that endoplasmic reticular oxidoreductase-1α (ERO1A) mediates an immune-suppressive and attenuates response to PD-1 blockade. Ablation ERO1A in cells substantially incites anti-tumor T cell immunity promotes efficacy aPD-1 therapeutic models. Single-cell RNA-sequencing analyses confirm correlates with...
The high heterogeneity of tumour and the complexity microenvironment (TME) greatly impacted development prognosis cancer in era immunotherapy. In this study, we aimed to portray single cell-characterised landscape lung adenocarcinoma (LUAD), develop an integrated signature incorporating both TME for stratification.
Non-small cell lung cancer (NSCLC) with KRAS mutation may be resistant to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI). This study aims evaluate a plasma-based analysis and the clinical significance of plasma as predictive marker for tumor resistance EGFR-TKIs in patients NSCLC.DNA extracted from matched tissues were obtained 273 advanced stage NSCLC. Patients followed up prospectively treatment outcomes. mutations codon 12 13 detected using PCR-restriction fragment...
Purpose This study evaluated occurrence and potential clinical significance of intratumoral EGFR mutational heterogeneity in Chinese patients with non-small cell lung cancer (NSCLC). Materials Methods Eighty-five stage IIIa-IV NSCLC who had undergone palliative surgical resection were included this study. Of these, 45 carried mutations (group-M) 40 wild-type (group-W). Each tumor sample was microdissected to yield 28–34 foci Intratumoral mutation determined using Denaturing High Performance...
// Xue Yang 1, * , Minglei Zhuo Xin Ye 2 Hua Bai 1 Zhijie Wang Yun Sun Jun Zhao Tongtong An Jianchun Duan Meina Wu Jie Department of Thoracic Medical Oncology, Key Laboratory Carcinogenesis and Translational Research (Ministry Education), Peking University Cancer Hospital Institute, Beijing, China Asia Emerging Markets Innovative Medicine AstraZeneca R & D, Shanghai, These authors contributed equally to this work Correspondence to: Wang, e-mail: zlhuxi@163.com Keywords: non-small-cell lung...
Purpose: No validated biomarkers that could identify the subset of patients with lung adenocarcinoma who might benefit from chemotherapy have yet been well established. This study aimed to explore potential biomarker model predictive efficacy and survival outcomes after first-line pemetrexed plus platinum doublet based on metabolomics profiling.Experimental Design: In total, 354 consecutive eligible were assigned receive in combination either cisplatin or carboplatin. Prospectively collected...
Background It is critical to minimize nurse turnover improve the quality of care and patient safety. In-depth investigation required better understand factors related nurses' intentions. Aim This study aimed determine relationships between burnout, general wellbeing, psychological detachment with intention among nurses in China. Methods A cross-sectional survey using convenience sampling was conducted one hospital China January 2023 March 2023. total 536 were surveyed General Wellbeing...
Metastases within liver or the brain are most common causes of mortality from lung cancer (LC). Predicting metastases before having evidence imaging tumors is challenging but important for early patient intervention. According to mounting evidence, exosomes circulating blood may facilitate spread by transporting certain proteins target cells.Using liquid chromatography-MS/MS, we investigated plasma exosomes' proteomic profiles derived 42 metastatic LC patients [16 solitary metastasis (LM),...
Rationale: Distant metastasis and chemoresistance are the major causes of short survival after initial chemotherapy in lung adenocarcinoma patients.However, underlying mechanisms remain elusive.Our pilot study identified high expression homeodomain transcription factor HOXB13 chemoresistant adenocarcinomas.We aimed to investigate role mediating chemoresistance.Methods: Immunohistochemistry assays were employed assess protein levels 148 non-small cell cancer patients.The progression...
Some driver gene mutations, including epidermal growth factor receptor ( EGFR ), have been reported to be involved in expression regulation of the immunosuppressive checkpoint protein programmed cell death ligand 1 PD ‐L1), but underlying mechanism remains obscure. We investigated potential role and precise mutants ‐L1 non‐small‐cell lung cancer NSCLC ) cells. Examination pivotal signaling effectors 8 lines indicated apparent associations between overexpression phosphorylation AKT ERK ,...
The aim of the study was to research biological functions circRNA (hsa_circ_0079662) and its underlying mechanism in colorectal cancer. Drug-resistant cell lines (HT29-LOHP, HCT116-LOHP, HCT8-LOHP) were separately dealt with oxaliplatin concentration gradient (0.1-10 μmol/L). Real-time PCR, Western blotting, dual-luciferase assay, miRNA pull-down coimmunoprecipitation ELASA performed explore chemotherapy drug resistance CRC. results showed that expression hsa_circ_0079662 increased...
<h3>Background</h3> To profile genomic and epigenomic of a naïve Chinese non-small cell lung cancer (NSCLC) cohort investigate the association between tumor mutation burden (TMB) DNA methylation (DNAm) to explore potential alternative/complimentary biomarkers for NSCLC immunotherapies. <h3>Methods</h3> A total 89 tissues with matched normal from patients were collected subjected whole exome sequencing (WES). From comparison, each patient was evaluated TMB value divided into high, medium low...
Abstract Background Cervical cancer is the fourth most common in women. Up to 99% of cervical cases are associated with high-risk human papillomavirus (HPV). Sexual behavior a direct risk factor for HPV infection, and sexually active college students, therefore, receive attention vaccination. At present, Chinese studies lack in-depth research on influencing factors, limited cancer, HPV, or vaccine, without comprehensive consideration. This study investigated students’ prevention treatment...
Although immune checkpoint inhibitors (ICIs) have influenced the treatment paradigm for multiple solid tumors, increasing evidence suggests that primary and adaptive resistance may limit long-term efficacy of ICIs. New therapeutic strategies with other drug combinations are hence warranted to enhance antitumor As a novel tumor suppressor, histone deacetylase (HDAC) inhibitor tucidinostat has been successfully confirmed act against hematological malignancies. However, underlying mechanisms...
Brain metastasis, with the highest incidence in patients lung cancer, significantly worsens prognosis and poses challenges to clinical management. To date, how brain metastasis evades immune elimination remains unknown.