A5039342081- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Circular RNAs in diseases
- High Altitude and Hypoxia
- Esophageal Cancer Research and Treatment
- RNA Research and Splicing
- Autophagy in Disease and Therapy
- Viral gastroenteritis research and epidemiology
- Metabolomics and Mass Spectrometry Studies
- Corneal Surgery and Treatments
- Cancer Genomics and Diagnostics
- Antibiotic Resistance in Bacteria
- Mitochondrial Function and Pathology
- Pharmaceutical and Antibiotic Environmental Impacts
- Lung Cancer Diagnosis and Treatment
- Cancer-related gene regulation
- Wastewater Treatment and Nitrogen Removal
- Biosensors and Analytical Detection
- Cancer Research and Treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Ferroptosis and cancer prognosis
Academy of Military Medical Sciences
2011-2025
Research Institute of Tropical Forestry
2020-2024
Chinese Academy of Forestry
2020-2024
China Southern Power Grid (China)
2021-2024
State Forestry and Grassland Administration
2023-2024
Kunshan Govisionox Optoelectronic (China)
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2010-2023
Guangxi Hydraulic Power Machinery Research Institute
2023
Qingdao University
2021-2023
Qingdao Municipal Hospital
2021-2023
Antibiotic resistance is a worldwide public health concern. Conjugative transfer between closely related strains or species of bacteria an important method for the horizontal multidrug-resistance genes. The extent to which nanomaterials are able cause increase in antibiotic by regulation conjugative antibiotic-resistance genes bacteria, especially across genera, still unknown. Here we show that water can significantly promote mediated RP4, RK2, and pCF10 plasmids. Nanoalumina RP4 plasmid...
Oesophageal cancer is one of the most deadly forms worldwide. Long non-coding RNAs (lncRNAs) are often found to have important regulatory roles.To assess lncRNA expression profile oesophageal squamous cell carcinoma (OSCC) and identify prognosis-related lncRNAs.LncRNA profiles were studied by microarray in paired tumour normal tissues from 119 patients with OSCC validated qRT-PCR. The divided randomly into training (n=60) test (n=59) groups. A prognostic signature was developed group using a...
Abstract Esophageal cancer is the sixth leading cause of death from and one least studied cancers worldwide. The global microRNA expression profile esophageal has not been reported previously. Here, for first time, we have investigated expressed microRNAs in cryopreserved tissues using advanced microarray techniques. Our analyses identified seven that could distinguish malignant lesions adjacent normal tissues. Some be correlated with different clinicopathologic classifications. High...
Recent studies have suggested that microRNA biomarkers could be useful for stratifying lung cancer subtypes, but signatures varied between different populations. Squamous cell carcinoma (SCC) is one major subtype of urgently needs to aid patient management. Here, we undertook the first comprehensive investigation on in Chinese SCC patients.MicroRNA expression was measured cancerous and noncancerous tissue pairs strictly collected from patients (stages I-III), who had not been treated with...
Lung cancer is the leading cause of cancer-related death in world and approximately 30–40% patients with stage Ⅰ non-small cell lung (NSCLC) die recurrent disease. miRNA expression profiles can be diagnostic prognostic markers cancer. Recently, miR-34 family has been shown to part p53 pathway which frequently involved cancer, reported regulated by DNA methylation. In present study, we investigated correlation between methylation status recurrence NSCLC patients. miR-34a miR-34b/c promoter...
Numerous studies have shown that long non-coding RNAs (lncRNAs) play key roles during multiple cancer processes, such as cell proliferation, apoptosis, migration and invasion. The previous found NKILA interacted with suppressed the nuclear translocation of NF-KappaB, which influenced metastasis prognosis in breast cancer. However clinical significance biological role non-small lung (NSCLC) remains unknown.We examined expression levels 106 pairs NSCLC tissues lines. level after TGF-β1...
The study aims to determine the efficacy and feasibility of a novel folate receptor (FR)-based circulating tumor cell (CTC) detection method in diagnosis non-small lung cancer (NSCLC). CTCs were collected from 3 ml blood based on negative enrichment by immunomagnetic beads then labeled conjugate tumor-specific ligand an oligonucleotide. After washing off redundant conjugates, bound conjugates removed analyzed quantitative polymerase chain reaction. captured cells validated as...
The aim of this study is to search the most powerful prognostic factor from routine blood test for esophageal squamous cell cancer (ESCC) patients. Multiple laboratory tests were evaluated including those reflecting red parameters (hemoglobin (Hb), mean corpuscular volume (MCV), hemoglobin concentration (MCHC), and distribution width (RDW)), platelet morphological (mean (MPV) count (PLT)), coagulation status (D-dimer), tumor biomarker (CA19-9). Known inflammatory indices (NLR PLR) also...
Cyclin E is reported to be an important cell cycle regulator, and its dysregulation implicated in tumorigenesis including esophageal squamous carcinoma (ESCC). MicroRNAs (miRNAs) regulate gene expression at the posttranscriptional level play roles tumor initiation progression. However, regulation of cyclin by miRNAs still unclear ESCC. In present study, we found that overexpression miR-29c inhibited targeting 3′ untranslated region messenger RNA ESCC cells. Moreover, induced G1/G0 arrest...
The potential risks of nano-materials and the spread antibiotic resistance genes (ARGs) have become two major global public concerns. Studies confirmed that nano-alumina can promote ARGs mediated by plasmids. Nano-titanium dioxide (TiO(2)), an excellent photocatalytic nano-material, has been widely used is often present in aqueous environments. At various nano-material concentrations, bacterial density, matting time, temperature, nano-TiO(2) significantly conjugation RP4 plasmid Escherichia...
Understanding interactions between tumor and the host immune system holds great promise to uncover biomarkers for targeted therapies clinical outcomes. However, systematical analysis of signatures in esophageal squamous cell carcinoma (ESCC) remains largely unstudied. In this study, containing 708 related genes were curated from mRNA microarray data with paired normal tissues 119 ESCC patients. Differential expression survival performed validations Human Protein Atlas an independent cohort...
Nanomaterial pollution and the spread of antibiotic resistance genes (ARGs) are global public health environmental concerns. Whether nanomaterials could aid transfer ARGs released from dead bacteria into live to cause is still unknown. Here, we demonstrated that nano-Al2O3 significantly promote plasmid-mediated transformation Gram-negative Escherichia coli strains Gram-positive Staphylococcus aureus; however, bulk Al2O3 did not have this effect. Under suitable conditions, 7.4 × 10(6)...
Purpose: No validated biomarkers that could identify the subset of patients with lung adenocarcinoma who might benefit from chemotherapy have yet been well established. This study aimed to explore potential biomarker model predictive efficacy and survival outcomes after first-line pemetrexed plus platinum doublet based on metabolomics profiling.Experimental Design: In total, 354 consecutive eligible were assigned receive in combination either cisplatin or carboplatin. Prospectively collected...
Abstract Acacia melanoxylon is well known as a valuable commercial tree species owing to its high-quality heartwood (HW) products. However, the metabolism and regulatory mechanism of during wood development remain largely unclear. In this study, both microscopic observation content determination proved that total amount starches decreased phenolics flavonoids increased gradually from sapwood (SW) HW. We also obtained metabolite profiles 10 metabolites related HW formation by metabolomics....
Lung cancer is the leading cause of cancer-related death in world. To explore tumor biomarkers for clinical application, two-dimensional fluorescence difference gel electrophoresis and subsequent MALDI-TOF/TOF mass spectrometry were performed to identify proteins differentially expressed 12 pairs lung squamous cell tumors their corresponding normal tissues. A total 28 nonredundant identified with significant alteration tumors. The up-regulation isocitrate dehydrogenase 1 (IDH1), superoxide...