A5049011675- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Radiomics and Machine Learning in Medical Imaging
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Esophageal Cancer Research and Treatment
- RNA modifications and cancer
- BRCA gene mutations in cancer
- Circular RNAs in diseases
- Cancer-related gene regulation
- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Epigenetics and DNA Methylation
- Peptidase Inhibition and Analysis
- Signaling Pathways in Disease
- Genetic factors in colorectal cancer
- Multiple and Secondary Primary Cancers
- Esophageal and GI Pathology
- Breast Cancer Treatment Studies
- Metastasis and carcinoma case studies
- Cancer Cells and Metastasis
- Cancer Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Immunotherapy and Immune Responses
Anhui Jianzhu University
2025
Peking University
2025
University of Science and Technology Beijing
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2010-2024
BGI Group (China)
2017-2024
Institute for Respiratory Health
2021
The University of Western Australia
2021
City University of Hong Kong
2020-2021
City University of Hong Kong, Shenzhen Research Institute
2021
Second Hospital of Anhui Medical University
2020
Oesophageal cancer is one of the most deadly forms worldwide. Long non-coding RNAs (lncRNAs) are often found to have important regulatory roles.To assess lncRNA expression profile oesophageal squamous cell carcinoma (OSCC) and identify prognosis-related lncRNAs.LncRNA profiles were studied by microarray in paired tumour normal tissues from 119 patients with OSCC validated qRT-PCR. The divided randomly into training (n=60) test (n=59) groups. A prognostic signature was developed group using a...
IntroductionProgrammed death receptor-1 (PD-1) inhibitors have shown efficacy in first-line treatment of NSCLC; however, evidence PD-1 inhibitor as neoadjuvant is limited. This a phase 1b study to evaluate the safety and outcome setting.MethodsTreatment-naive patients with resectable NSCLC (stage IA–IIIB) received two cycles sintilimab (200 mg, intravenously, day 1 out 22). Operation was performed between 29 43. Positron emission tomography–computed tomography scans were obtained at baseline...
Abstract Esophageal cancer is the sixth leading cause of death from and one least studied cancers worldwide. The global microRNA expression profile esophageal has not been reported previously. Here, for first time, we have investigated expressed microRNAs in cryopreserved tissues using advanced microarray techniques. Our analyses identified seven that could distinguish malignant lesions adjacent normal tissues. Some be correlated with different clinicopathologic classifications. High...
Recent studies have suggested that microRNA biomarkers could be useful for stratifying lung cancer subtypes, but signatures varied between different populations. Squamous cell carcinoma (SCC) is one major subtype of urgently needs to aid patient management. Here, we undertook the first comprehensive investigation on in Chinese SCC patients.MicroRNA expression was measured cancerous and noncancerous tissue pairs strictly collected from patients (stages I-III), who had not been treated with...
Programmed cell death protein-1 (PD-1) inhibitors have been proved to be feasible and efficacy in multiple cancers, including NSCLC. But few studies evaluated the effectiveness of PD-1 inhibitor as neoadjuvant therapy with a long-term follow-up. Here, this phase 1b study 3-year follow-up, we reported clinical outcomes patients who received therapy.Two doses sintilimab (intravenously, 200 mg) were used for stages IA IIIB NSCLC (registration number: ChiCTR-OIC-17013726). Then, surgery was...
Abstract Detecting volatile organic compounds (VOCs) in exhaled breath is a promising research area for disease diagnosis. Mass transfer behavior plays crucial role determining the detection performance of VOCs. However, high mobility poses substantial challenge mass process. Here, distinct mobile gaseous molecules discovered by employing schlieren imaging technique to visualize gas flow. The results demonstrate that hollow porous structures exhibit higher flow flux than solid film and...
Abstract Background It remains unclear whether addition of docetaxel to the combination a platinum and fluoropyrimidine could provide more clinical benefits than doublet chemotherapies in perioperative treatment for locally advanced gastric/gastro-esophageal junction (LAG/GEJ) cancer Asia. In this randomized, phase 2 study, we assessed efficacy safety plus oxaliplatin S-1 (DOS) versus (SOX) LAG/GEJ adenocarcinoma patients. Methods Patients with cT3–4 N any M0 G/GEJ were randomized (1:1)...
Cyclin E is reported to be an important cell cycle regulator, and its dysregulation implicated in tumorigenesis including esophageal squamous carcinoma (ESCC). MicroRNAs (miRNAs) regulate gene expression at the posttranscriptional level play roles tumor initiation progression. However, regulation of cyclin by miRNAs still unclear ESCC. In present study, we found that overexpression miR-29c inhibited targeting 3′ untranslated region messenger RNA ESCC cells. Moreover, induced G1/G0 arrest...
Lung cancer is the leading cause of cancer-related death in world. To explore tumor biomarkers for clinical application, two-dimensional fluorescence difference gel electrophoresis and subsequent MALDI-TOF/TOF mass spectrometry were performed to identify proteins differentially expressed 12 pairs lung squamous cell tumors their corresponding normal tissues. A total 28 nonredundant identified with significant alteration tumors. The up-regulation isocitrate dehydrogenase 1 (IDH1), superoxide...
Abstract Invasive micropapillary carcinoma (IMPC) has very high rates of lymphovascular invasion and lymph node metastasis been reported in several organs. However, the genomic mechanisms underlying its are unclear. Here, we perform whole-genome sequencing tumor cell clusters from primary IMPC paired axillary metastases. Cell multiple foci arise a single subclone tumor. We find evidence that monoclonal metastatic ancestor shares frequency copy-number loss PRDM16 IGSF9 copy number gain ALDH2...
Primary malignant melanoma of the esophagus is an extremely rare but highly aggressive tumor. The preoperative diagnosis complicated for lack specificity. Unfortunately, prognosis primary remains dismal from most literatures. To better understand this special condition, we reviewed medical records patients with in our center, retrospectively. Seven cases were seen at Cancer Hospital (Institute) Chinese Academy Medical Sciences 1975 through 2006. Six had complete clinical data. Of six...
Lung cancer remains the most common cause of death for malignancy in both men and women. Current therapies NSCLC patients are inefficient due to lack diagnostic therapeutic markers. The phospho-Ser/Thr-Pro specific prolyl-isomerase Pin1 is overexpressed many different cancers, including NSCLC, may possibly be used as a target therapy. We identified 79 cases with follow-up survival investigated clinical relevance expression patients. To validate oncogenic potential lung cells, we Glc82...
Esophageal squamous cell carcinoma (ESCC) patients with regional lymph node metastases have poor prognosis after surgery. The purpose of this study was to investigate the impact various treatment modalities on survival in these patients.We retrospectively reviewed data from 349 who had undergone left transthoracic esophagectomy for thoracic ESCC January 2008 December 2010 at our institute. All lesions mid or lower third segment and pathological positive metastasis. Of patients, 143 received...
The pathologic stages of lymph nodes usually differ from preoperatively predicted in lung cancers and it is difficult to predict the metastasis for patients diagnosed as clinical stage IA non-small cell (NSCLC). This study aimed investigate patterns node risk factors predicting with NSCLCs.All NSCLC July 2013 June 2017 our center were retrospectively reviewed, a total number 1,543 who underwent anatomical lobectomy systematic dissection enrolled this study. Multivariate logistic regression...
Abstract Background The role of postoperative radiotherapy in pathological T2–3N0M0 esophageal squamous cell carcinoma is unknown. We aimed to evaluate the efficacy and safety patients with thoracic carcinoma. Materials Methods Patients aged 18–72 years stage after radical surgery without neoadjuvant therapy were eligible. randomly assigned alone or receive 50.4 Gy supraclavicular field 56 mediastinal 28 fractions over 6 weeks. primary endpoint was disease-free survival. secondary endpoints...
Surgical resection of cancer remains the frontline therapy for millions patients annually, but post-operative recurrence is common, with a relapse rate around 45% non-small cell lung cancer. The tumour draining lymph nodes (dLN) are resected at time surgery staging purposes, and this cannot be null event patient survival future response to immune checkpoint blockade treatment. This project investigates surgery, lymphadenectomy, onset metastatic disease, immunotherapy in novel model that...
Abstract Purpose: Effective biomarkers for the diagnosis of non–small cell lung cancer (NSCLC) are needed. We previously showed that isocitrate dehydrogenase 1 (IDH1) is significantly increased in NSCLC tumors. This study aimed to examine plasma levels IDH1 a large patient population evaluate its effectiveness diagnosis. Experimental Design: The IDH1, CA125, Cyfra21-1, and CEA were assayed by ELISA. Blood samples obtained from 1,422 participants (943 patients with 479 healthy controls)....
Whole-genome bisulfite sequencing (WGBS) technology can provide comprehensive DNA methylation at a single-base resolution on genome-wide scale, and is considered to be the gold standard for detection of 5-methylcytosine (5 mC). However, International Human Epigenome Consortium propose full methylome should have least 30 fold redundant coverage reference genome from single biological replicate. Therefore, it remains cost prohibitive large-scale studies. To find solution, DNBSEQ-Tx was...
ABSTRACT Excitation wavelength‐dependent fluorescent materials are a class of whose fluorescence emission spectra drift significantly with excitation wavelength. Herein, carbon nitrides (CNNPs) emitting blue were synthesized by one‐pot method using urea as conjugated monomer and L‐phenylalanine co‐precursor. Waterborne polyurethane‐based nitride (CNNPs‐WPU) properties was produced accessing amino(‐NH 2 )‐rich CNNPs to waterborne polyurethane (WPU) modified acetone method. The results show...