A5023405903- Esophageal Cancer Research and Treatment
- Lung Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Advanced Radiotherapy Techniques
- Pancreatic and Hepatic Oncology Research
- Breast Cancer Treatment Studies
- Cancer Treatment and Pharmacology
- Radiomics and Machine Learning in Medical Imaging
- Drug Transport and Resistance Mechanisms
- Glycosylation and Glycoproteins Research
- Autoimmune Bullous Skin Diseases
- Organ Transplantation Techniques and Outcomes
- Platelet Disorders and Treatments
- Liver Disease and Transplantation
- Scoliosis diagnosis and treatment
- Reproductive Biology and Fertility
- Handwritten Text Recognition Techniques
- Advanced Breast Cancer Therapies
- Cancer survivorship and care
- Computational and Text Analysis Methods
- Liver Disease Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
- Global Cancer Incidence and Screening
- Cancer Risks and Factors
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2025
Peking Union Medical College Hospital
2020-2022
Peking University People's Hospital
2021
National Clinical Research
2020
Samsung Medical Center
2016
Seoul National University Hospital
2011-2016
Sungkyunkwan University
2016
Seoul National University Bundang Hospital
2011
Seoul National University
2011
Double-agent intravenous chemotherapy concurrent with radiotherapy is the standard of care for patients inoperable esophageal cancer. However, tend to tolerate less well age and comorbidities. It essential find a better treatment modality that improves survival outcomes without reducing quality life.To evaluate effectiveness simultaneous integrated boost (SIB-RT) consolidated oral S-1 aged 70 years older squamous cell carcinoma (ESCC).This multicenter, phase III randomized clinical trial was...
Abstract Background The role of postoperative radiotherapy in pathological T2–3N0M0 esophageal squamous cell carcinoma is unknown. We aimed to evaluate the efficacy and safety patients with thoracic carcinoma. Materials Methods Patients aged 18–72 years stage after radical surgery without neoadjuvant therapy were eligible. randomly assigned alone or receive 50.4 Gy supraclavicular field 56 mediastinal 28 fractions over 6 weeks. primary endpoint was disease-free survival. secondary endpoints...
Purpose To determine the survival and prognostic factors of esophageal squamous cell carcinoma (ESCC) patients undergoing radical (chemo)radiotherapy in era three-dimensional conformal radiotherapy (3DCRT) intensity modulated (IMRT) China.Material methods The Jing-Jin-Ji Esophageal Esophagogastric Cancer Radiotherapy Oncology Group (3JECROG) conducted first nationwide survey nine institutions. Detailed information was accumulated on 5185 with ESCC who received definitive 3DCRT/IMRT between...
ABSTRACT Background The recurrence patterns of different types pathologic regression the primary tumor and lymph nodes in patients with esophageal squamous cell carcinoma (ESCC) after neoadjuvant chemoradiotherapy (NCRT) are little known, especially ypT0N+ patients. Methods We included 582 ESCC who had esophagectomy NCRT or radiotherapy (NRT) from 3 institutions. were divided into 4 groups: ypT0N0, ypT0N+, ypT+N0, ypT+N+ according to type pathological nodes. Survival, pattern timing,...
Text-conditioned image generation has gained significant attention in recent years and are processing increasingly longer comprehensive text prompt. In everyday life, dense intricate appears contexts like advertisements, infographics, signage, where the integration of both visuals is essential for conveying complex information. However, despite these advances, images containing long-form remains a persistent challenge, largely due to limitations existing datasets, which often focus on...
Introduction: Intensive treatments can often not be administered to elderly patients with esophageal squamous cell carcinoma (ESCC), leading a poorer prognosis. This multi-center phase II trial aimed determine the toxicity profile and efficiency of S-1-based simultaneous integrated boost radiotherapy (SIB-RT) followed by consolidation chemotherapy S-1 in ESCC evaluate usefulness comprehensive geriatric assessment (CGA). Patients Methods: We prospectively enrolled 46 (age ≥ 70 years)...
Since the development of three-dimensional conformal radiotherapy and intensity-modulated (IMRT), no prospective study has investigated whether concurrent chemoradiotherapy (SIB-IMRT with 60 Gy) remains superior to (SIB-IMRT) alone for unresectable esophageal cancer (EC). Furthermore, optimal therapeutic regimen patients who cannot tolerate is unclear. We recently completed a phase I/II radiation dose-escalation trial using simultaneous integrated boost (SIB), elective nodal irradiation,...
Abstract Background To investigate the survival benefit of concurrent chemoradiotherapy (CCRT) for patients with locally advanced esophageal squamous cell carcinoma (ESCC) during years intensity‐modulated radiotherapy (IMRT). Methods Medical records 1089 ESCC who received IMRT from January 2005 to December 2017 were retrospectively reviewed. A total 617 CCRT, 472 (RT) alone. Propensity score matching (PSM) method was used eliminate baseline differences between two groups. Survival and...
This study aimed to determine the long-term survival of patients with cT4 esophageal cancer (EC) and whether neoadjuvant chemoradiotherapy/radiotherapy plus surgery (nCRT/RT + S) is superior definitive CRT(dCRT)/RT in terms EC downstaged after nCRT/RT.Treatment options for include dCRT/RT nCRT/RT S, but it not clear latter provides benefit nCRT/RT.From 2002 2017, 726 squamous cell carcinoma (ESCC) were retrospectively analyzed. Patients achieving clinical complete response (cCR) or partial...
Background The aim of this study was to compare the effects simultaneous integrated boost–intensity modulated radiotherapy (SIB-IMRT) and conventional fractionated-IMRT (CF-IMRT) for patients with esophageal squamous cell carcinoma (ESCC). Methods data 1173 treated either CF-IMRT or SIB-IMRT a curative intent from 2005 2016 were retrospectively reviewed. Propensity score matching (PSM) used create well-balanced cohort 687 at 1:2 ratio (237 in group 450 group). Overall survival (OS),...
Background It is still uncertain whether the newly released eighth American Joint Committee on Cancer (AJCC) post-neoadjuvant pathologic (yp) tumor-node-metastasis (TNM) stage for esophageal carcinoma can perform well regarding patient stratification. The current study aimed to assess prognostication ability of AJCC ypTNM staging system and attempted explore how facilitate more effective evaluation prognosis. Materials methods A total 486 patients treated with neoadjuvant...
To evaluate the impact of radiation dose escalation on overall survival (OS) in patients with non-metastatic esophageal squamous cell carcinoma (ESCC) treated radical radiotherapy.The clinical data ESCC three-dimensional (3D) radiotherapy alone or chemoradiotherapy were collected from multiple institutes and retrospectively analyzed. Patients who received ≥40 Gy included. Radiation as a continuous variable was entered into Cox regression model by using penalized spline to allow for nonlinear...
Despite receiving definitive chemoradiotherapy (dCRT) with radiation dose (RTD) of 50.4 Gy, survival esophageal carcinoma was dismal. The effect RTD in cancer control and radiotoxicity, the extent to which local-regional (LRC) influenced remain vague. This study aimed at evaluating RTD-effect relationship squamous cell (ESCC). 1440 dRT/CRT-treated ESCC patients were enrolled. Restricted cubic spline regression model applied reveal nonlinear between survival/radiotoxicity. Linear analysis...
The surrogacy of progression-free survival (PFS) for overall (OS) in esophageal squamous cell carcinoma (ESCC) remains unelucidated. This study aimed to determine the validity PFS as a surrogate endpoint OS ESCC patients treated with definitive radiotherapy or chemoradiotherapy (dRT/dCRT), well characterize prognostic factors and such patients.A total 3662 from 10 cancer centers were enrolled. One-, 2-, 3-year (PFS12, PFS24, PSF36, respectively) used time points analysis. At each point,...
Abstract Background Currently, adjuvant therapy is not recommended for patients with thoracic esophageal squamous cell cancer (TESCC) after radical surgery, and a proportion of these go on to develop locoregional recurrence (LRR) within 2 years. Besides, there no evidence salvage chemoradiation (CRT) in residual tumor esophagectomy (R1/R2 resection). In addition, factors like different failure patterns relationship normal organs influence the decision strategy. Here, we aimed design...
Objective To evaluate the survival and prognostic factors of esophageal cancer treated with definitive (chemo) radiotherapy by applying novel radiation techniques including three-dimensional conformal (3DCRT) or intensity-modulated (IMRT). Methods Clinical data 2762 patients non-operated squamous cell carcinoma who underwent from 2002 to 2016 in 10 hospitals were retrospectively analyzed.The also identified analyzed. Results The median follow-up time was 60.8 months.The 1-,...
Background: For patients with esophageal squamous cell carcinoma (ESCC) treated surgery alone, the incidence of local-regional recurrence remains unfavorable. Postoperative radiotherapy (PORT) has been associated increased recurrence-free survival (LRFS), although its application is limited by concerns PORT-related toxicities. Methods: Among 3591 ESCC analyzed in this study, 2765 T3-4N0 and T1-4N1-3 lesions specific status information were a subsequent analysis adjuvant radiation dose (aRTD)...
Abstract Background : Since the development of three-dimensional conformal radiotherapy and intensity-modulated (IMRT), no prospective study has investigated whether concurrent chemoradiotherapy (SIB-IMRT with 60 Gy) remains superior to (SIB-IMRT) alone for unresectable esophageal cancer (EC). Furthermore, optimal therapeutic regimen patients who cannot tolerate is unclear. We recently completed a phase I/II radiation dose-escalation trial using simultaneous integrated boost (SIB), elective...
Abstract Background Existing evidence strongly suggests that exercise is not only safe but also feasible during cancer treatment. Physical activity recommended for improving multiple post-treatment adverse effects on bone health, muscle strength, and other quality-of-life measures. Yet, limited exists regarding effect of increased physical after diagnosis symptoms management breast patients. Methods A total 422 patients were recruited from July 2010 to 2011 at two hospitals in Seoul, Korea....
Abstract BACKGROUND: Although chemotherapy and ovarian ablation independently improve the outcome of breast cancer, there is controversy about benefit chemotherapy-induced amenorrhea (CIA) in cancer. We investigated impact CIA on response to neoadjuvant cancer patients. METHODS: reviewed records 198 premenopausal patients with treated between January 2005 December 2010. Chemotherapy-induced was defined as serum FSH level ≥40 IU/L after completion all scheduled prior definitive surgery....
Abstract Background Expression of the adenosine triphosphate-binding cassette B1 (ABCB1) transporter and P-glycoprotein are associated with resistance to anticancer drugs. The purpose this thesis was investigate role single nucleotide polymorphism (SNP) in ABCB1 CYP3A genes breast cancer patients who were treated neoadjuvant docetaxel doxorubicin chemotherapy. Material Methods: Patients histologically confirmed cancer, Stage II or III, referred for chemotherapy enrolled. 3 cycles adjuvant...