The two oxidation states of ceria nanoparticles, Ce3+ and Ce4+, play a pivotal role in scavenging reactive oxygen species (ROS). In particular, is largely responsible for removing O2− .OH that are associated with inflammatory response cell death. synthesis reported 2 nm ceria–zirconia nanoparticles (CZ NPs) possess higher Ce3+/Ce4+ ratio faster conversion from Ce4+ to than those exhibited by nanoparticles. obtained Ce0.7Zr0.3O2 (7CZ) NPs greatly improve ROS performance, thus regulating cells...

Intracranial arterial disease (ICAD) is a heterogeneous condition characterized by distinct pathologies, including atherosclerosis. Advances in magnetic resonance technology have enabled the visualization of intracranial arteries using high-resolution vessel wall imaging (HR-VWI). This review summarizes anatomical, embryological, and histological differences between extracranial arteries. Next, we pathophysiology ICAD, atherosclerosis, moyamoya or RNF213 spectrum disease, dissection,...

The current guideline recommends moderate- to vigorous-intensity physical activity (PA) at least 40 min/day for 3 4 days/week. Although recent evidence has demonstrated that low-dose PA could reduce cardiovascular mortality, the relationship between and risk of stroke remains uncertain.Using data from a nation-wide sample cohort in Korea, we examined 336 326 individuals who received general health examination 2009 2010. Level was assessed using questionnaire weekly frequencies regarding...

Abstract The two oxidation states of ceria nanoparticles, Ce 3+ and 4+ , play a pivotal role in scavenging reactive oxygen species (ROS). In particular, is largely responsible for removing O 2 − . OH that are associated with inflammatory response cell death. synthesis reported nm ceria–zirconia nanoparticles (CZ NPs) possess higher /Ce ratio faster conversion from to than those exhibited by nanoparticles. obtained 0.7 Zr 0.3 (7CZ) NPs greatly improve ROS performance, thus regulating cells...

Background and Purpose- Despite early aneurysm repair aggressive management for complications, subarachnoid hemorrhage (SAH) results in at least 25% mortality rate 50% persistent neurological deficit. We investigated whether ceria nanoparticles which have potent antioxidative activities can protect against via attenuating fatal brain injuries. Methods- Uniform, 3 nm, water-dispersed were prepared from short sol-gel reaction of cerium (III) ions with aminocaproic acid aqueous phase. SAH was...

Abstract Systemic inflammatory response syndrome (SIRS) is self‐destructive and uncontrollable of the whole body triggered by infection, trauma, or a variety severe injuries. Although reactive oxygen species play pivotal role in development SIRS, trials with conventional antioxidants have failed to improve patient outcome. Ceria nanoparticles (CeNPs) potent, autocatalytic scavenging activities, which may sufficient therapeutic effects for SIRS. Herein, 3 nm CeNPs are fabricated totally...

The effect of clonal hematopoiesis indeterminate potential (CHIP) on the manifestation and clinical outcomes acute ischemic stroke (AIS) has not been fully elucidated.Patients with AIS were included from a prospective registry coupled DNA repository. Targeted next-generation sequencing 25 genes that are frequently mutated in hematologic neoplasms was performed. prevalence CHIP compared between patients age-matched healthy individuals. A multivariate linear or logistic regression model used...

Clinical guidelines recommend warfarin for patients with antiphospholipid syndrome (APS) and ischemic stroke; however, robust evidence is lacking. We investigated the clinical benefits of different categories antithrombotic medications in stroke positive antibodies (aPLs) real-world practice. reviewed data from or transient attack who tested aPLs. Based on their secondary preventive medications, were classified into antiplatelet anticoagulant categories, further warfarin, single therapy...

Background: This study aimed to investigate the radiographic measurements associated with progression of hallux valgus during at least 2 years follow-up. Methods: Seventy adult patients who were followed for and underwent weightbearing foot radiography included. Radiographic included angle (HVA), interphalangeal angle, intermetatarsal (IMA), metatarsus adductus distal metatarsal articular (DMAA), tibial sesamoid position, anteroposterior (AP) talo–first lateral angle. Patients divided into...

This study was undertaken to evaluate the clinical characteristics and efficacy of lateral tarsal strip (TS) medial spindle procedure (MS). We conducted a retrospective chart review patients who underwent TS MS between September 2008 July 2011 by single surgeon (S.H.B.). Data were collected on patient age, sex, laterality, diagnosis, procedures performed simultaneously, follow-up duration, postoperative complications, surgical outcomes. One hundred eleven eyelids 74 41 29 included in this...

Abstract Artificial nerve guidance conduits (aNGCs) prepared from polymer scaffolds and carbon nanotubes (CNTs) possess unique chemical physical properties, have been widely used in preclinical trials to promote neuronal differentiation growth. However, there only a few reports on the clinical applicability of CNT sheets for proliferation primary cells due safety concerns. The present study assesses ability potential multiwalled CNTs (MWNTs) composited with polydimethylsiloxane (PDMS)...

Maintenance of optimal knee joint line orientation (KJLO) is important after high tibial osteotomy (HTO). No tools, however, are currently available that could predict the value postoperative KJLO before surgery. First, this study sought to determine effects various preoperative anatomical alignment parameters KJLO. Based upon these analyses, we aimed devise an equation predicts KJLO.A total 14 radiographic were measured in and full-limb standing anteroposterior radiographs on 50 patients...

Pontine infarction is a common type of brain stem and early neurological deterioration (END). We evaluated the possibility severe white matter hyperintensity (WMH) as predictor END in isolated pontine infarction.We recruited 2 types patients with within 24 h from symptom onset. was defined an increase ≥1 point on motor National Institutes Health Stroke Scale (NIHSS) or ≥2 points total NIHSS score 72 admission. graded WMH using Fazekas scale, which dichotomized into mild (grades 0-1) moderate...

Gamma-glutamyl transferase (GGT) is reported to be associated with stroke independently of the conventional risk factors. However, underlying mechanism remains identified. This study focused on atrial fibrillation (AF), which also reportedly has a close association GGT.Acute ischemic patients who were admitted Seoul National University Hospital within 7 days onset analyzed. Multinomial logistic regression was performed assess relationship between GGT and cardioembolic stroke. Mediation...

The protein kinase A (PKA)/cAMP response element-binding (CREB) has been suggested to be related the inhibition of proliferation non-small cell lung cancer (NSCLC) cells. This study aimed investigate efficacy a novel diarylcyclohexanone derivative, MHY4571, in regulating PKA-CREB pathway and its anti-tumor role squamous NSCLC.We designed MHY4571 as PKA inhibitor with acceptable silico ADME properties tested it vitro lines vivo xenograft orthotopic mouse models carcinoma.MHY4571 inhibited...

Hemifacial spasm (HFS) caused by vertebrobasilar dolichoectasia (VBD) is very rare, and in theses cases, it difficult to decompress the nerve from its vascular compression. The objective of this study was investigate outcome microvascular decompression (MVD) for HFS VBD.There were 10 patients VBD at our hospital between September 1978 2008. We evaluated magnetic resonance angiography (MRA) time flight imaginge (TOF MRI) findings using criteria VBD. compared clinical outcomes MVD with overall...

Although it has been reported that the amount of alcohol consumption a J-shaped association with ischemic stroke, is unclear whether differences in drinking patterns affect this relationship. We aimed to clarify impact on stroke midlife.We used data from National Health Insurance Service-National Sample Cohort, which large-sized, standardized population cohort Korea. Five different were defined by combining frequency and quantity consumed per occasion, is, abstainers, not alcohol; drinker...

Although it is not recognized as essential to test for antiphospholipid antibody (aPL) in stroke of unknown cause, aPL-related may account a considerable number cryptogenic strokes. We aimed assess the current status and diagnostic value aPL testing patients.Consecutive patients admitted with acute ischemic were examined confirm factors associated performing positive results real-world practice. Cryptogenic separately same manner. The profiles positivity compared by age.Among 2947 patients,...

Multiple attempts at intracranial hemorrhage (ICH) detection using deep-learning techniques have been plagued by clinical failures. We aimed to compare the performance of a algorithm for ICH trained on strongly and weakly annotated datasets, assess whether weighted ensemble model that integrates separate models datasets with different improves performance. used brain CT scans from Radiological Society North America (27,861 scans, 3,528 ICHs) AI-Hub (53,045 7,013 training. DenseNet121,...

Background: Although pedobarographic measurement is increasingly used for clinical and research purposes, relatively few published studies have investigated normative data.This study examined findings in young healthy adults with regard to sex-related differences correlations among indices.Methods: Twenty (mean age, 22.4 years; standard deviation, 1.2 10 males females) were included.Weight bearing anteroposterior (AP) lateral foot radiographs taken, dynamic data during treadmill walking...