A5013850008- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Breast Cancer Treatment Studies
- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- Prostate Cancer Treatment and Research
- Cancer Immunotherapy and Biomarkers
- Metastasis and carcinoma case studies
- Trypanosoma species research and implications
- Breast Lesions and Carcinomas
- Advanced Radiotherapy Techniques
- Brain Metastases and Treatment
- Cancer Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Hormonal Regulation and Hypertension
- Esophageal and GI Pathology
- Colorectal Cancer Surgical Treatments
- Sarcoma Diagnosis and Treatment
- Biochemical and Molecular Research
- Breast Implant and Reconstruction
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Treatment and Pharmacology
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2025
Jiujiang First People's Hospital
2024
Shenzhen Bay Laboratory
2024
Henry M. Jackson Foundation
2022
Uniformed Services University of the Health Sciences
2022
Peking Union Medical College Hospital
2016-2022
Northeast Petroleum University
2020-2022
Weatherford College
2022
National Clinical Research
2020
Naval Medical Research Command
2020
Background Immune checkpoint inhibitors (ICIs) have revolutionized the treatment landscape for locally advanced non-small-cell lung cancer (LA-NSCLC), whereas responses to anti-programmed cell death-1 (PD-1) or death-ligand 1 (PD-L1) are heterogeneous. Though consolidation ICI following concurrent chemoradiotherapy (cCRT) improves survival of NSCLC, this regimen is challenging patients with bulky tumors due excessive target volumes and radiation-resistant hypoxia during upfront cCRT, leading...
Introduced in the 1950s, ethidium bromide (EB) is still used as an anti-trypanosomal drug for African cattle although its mechanism of killing has been unclear and controversial. EB long known to cause loss mitochondrial genome, named kinetoplast DNA (kDNA), a giant network interlocked minicircles maxicircles. However, existence viable parasites lacking kDNA (dyskinetoplastic) led many think that could not be killing. When recent studies indicated indeed essential bloodstream trypanosomes...
Whilst survival benefits of thoracic radiotherapy (TRT) followed by immune checkpoint inhibitor (ICI) have been reported in patients with lung cancer, the potential high risk treatment-related pneumonitis remains a concern. Asians may be more sensitive to toxicity than other races. This retrospective study intended provide comprehensive profile TRT ICI and investigate factors from Chinese cohort cancer. From January 2016 July 2021, 196 cancer who received prior were retrospectively analyzed....
The potential of circulating tumour DNA (ctDNA) as a reliable biomarker for relapse/metastasis early detection and prognosis in esophageal squamous cell carcinoma (ESCC) after radiotherapy/chemoradiotherapy (RT/CRT) initiation requires comprehensive investigation.Treatment-naive locally advanced ESCC patients with available baseline plasma samples were prospectively enrolled from November 2018 to January 2020. RT/CRT was delivered simultaneous integrated boost radiation dose. Serial...
Double-agent intravenous chemotherapy concurrent with radiotherapy is the standard of care for patients inoperable esophageal cancer. However, tend to tolerate less well age and comorbidities. It essential find a better treatment modality that improves survival outcomes without reducing quality life.To evaluate effectiveness simultaneous integrated boost (SIB-RT) consolidated oral S-1 aged 70 years older squamous cell carcinoma (ESCC).This multicenter, phase III randomized clinical trial was...
Abstract Hepatocellular carcinoma (HCC) is one of the most common malignancies in world and associated with high mortality. Ionizing radiation (IR)‐based therapy causes DNA damage, exerting a curative effect; however, damage repair signaling pathways lead to HCC resistance IR‐based therapy. RAD21 component cohesion complex, crucial for chromosome segregation repair, while it still unclear whether implicated influences IR sensitivity HCC. The current research explores effect upstream...
Abstract Background Concurrent epidermal growth factor receptor‐tyrosine kinase inhibitors (EGFR‐TKI) with radiotherapy in patients EGFR ‐mutant unresectable stage III non‐small cell lung cancer (NSCLC) might improve survival. However, both treatments carry a potential risk of pneumonitis. Methods Between May 2012 and December 2017, NSCLC treated concurrent EGFR‐TKI were enrolled this retrospective study. The baseline characteristics evaluated to determine correlations toxicity development....
Purpose: We constructed a prediction model to predict 2-year locoregional recurrence based on the clinical features and radiomic extracted from machine learning method using computed tomography (CT) before definite chemoradiotherapy (dCRT) in locally advanced esophageal cancer. Patients methods: A total of 264 patients (156 Beijing, 87 Tianjin, 21 Jiangsu) were included this study. All those cancer received radiotherapy randomly divided into five subgroups with similar number training groups...
The ADAURA study indicated that adjuvant TKI therapy improves survival in postoperative patients with EGFR-mutated (EGFRm) non-small-cell lung cancer (NSCLC), especially stage III disease. However, the effect of PORT for (N2) NSCLC different EGFR statuses remains unclear, which we aimed to investigate present study. Between 2006 and 2019, consecutive pN2 non-squamous cell (Nsq-NSCLC) after complete resection chemotherapy or tyrosine kinase inhibitor (TKI) who had detection status were...
Abstract Predicting the effect of consolidation immunotherapy after chemoradiotherapy (CRT) for unresectable locally advanced non‐small‐cell lung cancer (LA‐NSCLC) patients remains a challenge, given restricted sensitivity single circulating tumor DNA (ctDNA) molecular residual disease (MRD) detection. In this study, 384 longitudinal blood samples from 160 with LA‐NSCLC undergoing CRT ± immunotherapy, tissue whole‐genome or whole‐exome sequencing (WGS/WES) 421 treated radiotherapy, and...
Introduction With the inspiring results of PACIFIC trial in non-small-cell lung cancer (NSCLC), and CAPIAN IMpower133 trials extensive-stage small-cell (SCLC), immunotherapy has increasingly gained attention. Serplulimab, a PD-1 inhibitor, showed great antitumour activity ASTRUM-005 been recommended as first-line therapy SCLC. Whether serplulimab following hypofractionation radiotherapy chemotherapy could bring better outcomes limited-stage SCLC remains to be answered. Methods analysis We...
Kinetoplast DNA (kDNA), the mitochondrial genome of trypanosomatids, is a giant planar network catenated minicircles and maxicircles. In vivo kDNA organized as highly condensed nucleoprotein disk. So far, in Trypanosoma brucei, proteins involved maintenance structure remain poorly characterized. Crithidia fasciculata, some small basic histone H1-like kinetoplast-associated (CfKAP) have been shown to condense isolated networks vitro. High-mobility group (HMG) box-containing proteins, such...
Abstract Background Dacomitinib is a second‐generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) which superior to first‐generation EGFR TKI in ARCHER 1050. However, the activity of dacomitinib central nervous system (CNS) not known as 1050 did include patients with baseline brain metastases. This study aimed describe dacomitinib's CNS real‐world setting. Patients and Methods Thirty‐two who were receiving for advanced non‐small‐cell lung cancer (NSCLC) mutations...
Liquid biopsy-based biomarkers, including circulating tumor DNA (ctDNA) and blood mutational burden (bTMB), are recognized as promising predictors of prognoses responses to immune checkpoint inhibitors (ICIs), despite insufficient sensitivity single biomarker detection. This research aims determine whether the combinatorial utility longitudinal ctDNA with bTMB analysis could improve prognostic predictive effects.
Abstract Background The value of postoperative radiotherapy (PORT) for patients with non-small cell lung cancer (NSCLC) remains controversial. A subset may benefit from PORT. We aimed to identify NSCLC who could Methods Patients cohorts 1 and 2 pathological Tany N2 M0 were included, as well non-metastatic 3 6. radiomic prognostic index (RPI) was developed using texture features extracted the primary nodule in preoperative chest CT scans cohort validated other cohorts. employed a least...
To evaluate the efficacy and safety of nab-paclitaxel plus cisplatin as regimen conversional chemoradiotherapy (cCRT) in locally advanced borderline resectable or unresectable esophageal squamous cell carcinoma (ESCC).
To establish prediction models to predict 2-year overall survival (OS) and stratify patients with different risks based on radiomics features extracted from magnetic resonance imaging (MRI) computed tomography (CT) before definite chemoradiotherapy (dCRT) in locally advanced esophageal squamous cell carcinoma (ESCC). Patients ESCC were recruited. We 547 MRI CT images. The least absolute shrinkage selection operator (LASSO) for COX algorithm was used obtain highly correlated outcomes the...