A5045899101- Bone Tissue Engineering Materials
- Mesenchymal stem cell research
- Dental Implant Techniques and Outcomes
- Bone Metabolism and Diseases
- Dental materials and restorations
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Dental Research and COVID-19
- Dental Radiography and Imaging
- Graphene and Nanomaterials Applications
- Bone and Dental Protein Studies
- Orthodontics and Dentofacial Orthopedics
- Esophageal Cancer Research and Treatment
- Temporomandibular Joint Disorders
- Periodontal Regeneration and Treatments
- Magnesium Alloys: Properties and Applications
- Cancer Cells and Metastasis
- Tissue Engineering and Regenerative Medicine
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- TGF-β signaling in diseases
- 3D Printing in Biomedical Research
- Lung Cancer Diagnosis and Treatment
- Circular RNAs in diseases
- Bone health and treatments
King University
2019-2025
Peking University
2016-2025
National Clinical Research
2018-2025
National Clinical Research Center for Digestive Diseases
2018-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2025
Stomatology Hospital
2016-2025
Chinese Center For Disease Control and Prevention
2025
University of Science and Technology Beijing
2021-2024
Chengdu Third People's Hospital
2024
Sichuan University
2024
Exosomes, nanoscale extracellular vesicles functioning as cell-to-cell communicators, are an emerging promising therapeutic in the field of bone tissue engineering. Here, we report construction and evaluation a novel cell-free tissue-engineered that successfully accelerated restoration critical-sized mouse calvarial defects through combining exosomes derived from human adipose-derived stem cells (hASCs) with poly(lactic-co-glycolic acid) (PLGA) scaffolds. The were immobilized on...
Abstract Objectives The present study aimed to investigate whether exosomes derived from miR‐375‐overexpressing human adipose mesenchymal stem cells (hASCs) could enhance bone regeneration. Materials and Methods Exosomes enriched with miR‐375 (Exo [miR‐375]) were generated hASCs stably overexpressing after lentiviral transfection identified transmission electron microscopy, nanosight western blotting. construction efficiency of Exo (miR‐375) was evaluated qRT‐PCR incubated marrow (hBMSCs)...
Skin wounds are a major medical challenge that threaten human health. Functional hydrogel dressings demonstrate great potential to promote wound healing. In this study, magnesium (Mg) and zinc (Zn) introduced into methacrylate gelatin (GelMA) via low-temperature magnetic stirring photocuring, their effects on skin the underlying mechanisms investigated. Degradation testing confirmed GelMA/Mg/Zn released ions (Mg2+) (Zn2+) in sustained manner. The Mg2+ Zn2+ not only enhanced migration of...
Polycaprolactone (PCL) is a polymer material suitable for being prepared into porous scaffolds used in bone tissue engineering, however, insufficient osteogenic ability and mechanical strength limit its application. Zinc (Zn) alloy with proper osteogenesis promising biodegradable metal that have attracted much attention. Herein, we combined the advantages of PCL Zn by fabricating PCL/Zn composite different powder contents (1 wt%, 2 3 wt%) through fused deposition modelling. The mechanical...
Abstract Osteogenic differentiation and bone formation is suppressed under condition of inflammation induced by proinflammation cytokines. A number studies indicate miRNAs play a significant role in tumor necrosis factor-α-induced inhibition formation, but whether long non-coding RNAs are also involved this process remains unknown. In study, we evaluated the MIR31HG osteogenesis human adipose-derived stem cells (hASCs) vitro vivo. The results suggested that knockdown not only significantly...
Abstract Background Recently, there has been considerable innovation in artificial intelligence (AI) for healthcare. Convolutional neural networks (CNNs) show excellent object detection and classification performance. This study assessed the accuracy of an application marginal bone loss on periapical radiographs. Methods A Faster region-based convolutional network (R-CNN) was trained. Overall, 1670 radiographic images were divided into training (n = 1370), validation 150), test 150)...
Abstract Bone marrow mesenchymal stromal/stem cells (MSCs) are a heterogeneous population that can self-renew and generate stroma, cartilage, fat, bone. Although significant progress has been made toward recognizing about the phenotypic characteristics of MSCs, true identity properties MSCs in bone remain unclear. Here, we report expression landscape human fetal BM nucleated (BMNCs) based on single-cell transcriptomic analysis. Unexpectedly, while common cell surface markers such as CD146,...
Abstract Peri-implantitis is a bacterial infection that causes soft tissue inflammatory lesions and alveolar bone resorption, ultimately resulting in implant failure. Dental implants for clinical use barely have antibacterial properties, colonization biofilm formation on the dental are major of peri-implantitis. Treatment strategies such as mechanical debridement antibiotic therapy been used to remove plaque. However, it particularly important prevent occurrence peri-implantitis rather than...