A5056623428- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Advanced Radiotherapy Techniques
- Esophageal Cancer Research and Treatment
- Neuroendocrine Tumor Research Advances
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Radiomics and Machine Learning in Medical Imaging
- Gastric Cancer Management and Outcomes
- Inflammatory Biomarkers in Disease Prognosis
- Brain Metastases and Treatment
- Hip and Femur Fractures
- Cancer Genomics and Diagnostics
- Head and Neck Cancer Studies
- Organ Transplantation Techniques and Outcomes
- Esophageal and GI Pathology
- Immune Cell Function and Interaction
- MicroRNA in disease regulation
- Glioma Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
First Affiliated Hospital of GuangXi Medical University
2022-2024
Guangxi Medical University
2012-2024
Deyang Stomatological Hospital
2020-2024
National Clinical Research
2023-2024
Hainan Center for Disease Control & Prevention
2024
University of South China
2024
Nanjing Chest Hospital
2024
Nanjing Brain Hospital
2024
Nanjing Medical University
2024
Abstract Background The systemic immune-inflammation index (SII), based on peripheral platelet, neutrophil and lymphocyte counts, has been proven to be a promising prognostic indicator in various diseases. Hip fracture is common injury among the older adults, become global public health problem with high mortality disability rates. However, relationship between SII prognosis of hip not yet well-known. aim this study was explore predictive value adults undergoing surgery. Methods This...
Advances in the immunology have identified that interleukin (IL)‑17 and IL‑35 are cytokines with diverse functions, serving important roles autoimmune diseases chronic inflammation. Checkpoint inhibitor pneumonitis (CIP) is focal or diffuse lung inflammation induced by immune checkpoint inhibitors underlying pathogenesis has not been fully explored. The aim of present study was to investigate IL‑17A IL‑35, correlation between their levels different T cell subsets CIP. peripheral blood...
Abstract Homologous recombination/end joining (HR/HEJ)-deficient cancers with BRCA mutations utilize alternative DNA double-strand break repair pathways, particularly non-homologous end or microhomology-mediated (alt-EJ/MMEJ) during S and G2 cell cycle phases. Depletion of alt-EJ factors, including XRCC1, PARP1 POLQ, is synthetically lethal BRCA2 deficiency; yet, XRCC1 roles in HR-deficient replication stress are enigmatic. Here, we show that after stress, forms an active complex POLQ MRE11...
Whilst survival benefits of thoracic radiotherapy (TRT) followed by immune checkpoint inhibitor (ICI) have been reported in patients with lung cancer, the potential high risk treatment-related pneumonitis remains a concern. Asians may be more sensitive to toxicity than other races. This retrospective study intended provide comprehensive profile TRT ICI and investigate factors from Chinese cohort cancer. From January 2016 July 2021, 196 cancer who received prior were retrospectively analyzed....
Abstract Background. Consistent results are lacking as regards the comparative effectiveness of intensity-modulated radiotherapy (IMRT) versus three-dimensional conformal (3DCRT) in patients with locally advanced non-small cell lung cancer (LA-NSCLC). Patients and Methods. treated definitive (RT) between 2002 2010 were retrospectively reviewed. Overall survival (OS), local-regional progression-free (LRPFS), distant metastasis-free (DMFS), (PFS) compared among irradiated different techniques....
Up-front stereotactic radiosurgery (SRS) has been historically thought of as inadequate for brain metastases (BM) from newly diagnosed small cell lung cancer (SCLC). This study evaluates national practice patterns and clinical outcomes BM SCLC.The National Cancer Database was queried (2004-2013) patients with metastatic SCLC receiving intracranial radiotherapy. Patients were grouped into three categories: upfront SRS, whole-brain radiotherapy (WBRT) alone, or WBRT boost (SRS fractionated...
The purpose of this case report is to compare the dosimetric disparities between photon radiotherapy and intensity-modulated proton therapy (IMPT) with or without deep inspiration breath hold (DIBH) for cardiac tumors. We present a involving 66-year-old female metastasis from thymic carcinoma. A total dose 50Gy/50Gy(RBE) in 25 fractions was administered metastases. Two simulation CT scans were obtained during free (FB) DIBH. Dose distribution target organs at risk(OARs) compared intensity...
Dental diseases, especially dental caries, are significant issues affecting population health worldwide. caries has been listed by the World Health Organization as one of three key diseases to be prevented and treated, following cardiovascular cancer. It a high incidence rate wide distribution, posing serious threat people’s oral quality life [1–5]. With intensification global aging changes in dietary habits, is on rise, becoming public problem that cannot ignored. Therefore, exploring new...
Background: The goal of this study is to assess the newest survival hepatoblastoma (HB) and risk factors which impacted on by using Surveillance, Epidemiology End Results (SEER) database, also calculate incidence HB in recent years. Methods: We age-adjusted SEER 21 registries. Age, sex, race, tumor size, macrovascular involvement, multifocal tumor, distant metastasis, way treatment, were collected for analysis prognostic 18 Survival curves, according different factors, obtained Kaplan-Meier...
<h3>Importance</h3> Palliative radiotherapy (RT) is generally recommended for older patients with esophageal squamous cell carcinoma (ESCC) poor prognosis. A new combination treatment therefore needed. <h3>Objective</h3> To assess the efficacy and toxicity of RT plus icotinib vs alone in ESCC. <h3>Design, Setting, Participants</h3> This randomized, multicenter, open-label, phase II clinical trial was conducted China, enrollment between January 1, 2015, October 31, 2016. Patients aged 70...
Abstract To evaluate the impact of Qinshan Nuclear Power Plant (Qinshan NPP) in normal operation on surrounding environment and population, radioactivity levels drinking water ambient environment, as well residents’ cancer incidence, were continuously monitored for a period 9 years (2012–2020). All gross α β concentrations less than WHO recommended values (0.5 Bq/L 1 ). The results accumulated dose by thermoluminescent dosimeters (TLDs) indicated that radioactive level around NPP is...
Pembrolizumab, a programmed cell death protein 1 checkpoint inhibitor, is novel drug used to treat variety of advanced malignancies. However, it can also result in many immune-related adverse events, with cutaneous toxicities being the most frequent. Regarding pembrolizumab-induced skin reactions, bullous pemphigoid (BP) has worst effects on quality life. Recently, there have been more and reports BP incidents resulting from pembrolizumab therapy patients cancer. This study aimed define...
Abstract Background Combination of chidamide and anti‐PD‐L1 inhibitor produce synergistic anti‐tumor effect in advanced NSCLC patients resistant to anti‐PD‐1 treatment. However, the plus envafolimab has not been reported. Aims This study aimed evaluate efficacy toanti‐PD‐1 Materials Methods Eligible after therapy received envafolimab. The primary endpoint was objective response rate (ORR). secondary end points included disease control (DCR), progression‐free survival (PFS), safety....
Backgrounds Oral squamous cell carcinoma is a malignant tumor of the head and neck, its molecular mechanism remains to be explored. Methods By analyzing OSCC data from TCGA database, we found that SLC2A3 highly expressed in patients. The expression level was verified by RT-PCR western blotting lines. function lines Lactic acid SLC2A3-knockdown cells were detected colony formation, CCK8, transwell, wound healing assays. effect on growth metastasis tested vivo. GSEA Western blot used analyze...
Uncommon epidermal growth factor receptor (EGFR) gene mutant locally advanced non-small cell lung cancer (NSCLC) has been poorly documented in the literature. Our study aimed to investigate clinical features and outcomes associated with these mutations. A multi-center retrospective was conducted review 511 patients EGFR unresectable stage III adenocarcinoma, treated between 2012 2018 across 12 Chinese institutions. The were categorized into three groups based on their primary treatment:...
e22000 Background: Inotuzumab ozogamicin (InO) is FDA approved for adult and pediatric (≥1 y) patients (pts) with relapsed/refractory (R/R) B-cell precursor acute lymphoblastic leukemia (ALL). However, InO has been associated increased risk of sinusoidal obstruction syndrome (SOS), particularly following hematopoietic cell transplantation (HCT). Previously reported post-HCT SOS rates are ~20% in adults ~20–50% pts who received before HCT. Methods: This observational, post-authorization...
3109 Background: Limitations of approved BRAF V600E inhibitors include toxicity from paradoxical activation RAF dimerization as well limited brain penetration. In contrast to agents, investigational pan-RAF both inhibit mutant proteins and wild-type (wt) proteins, leading a narrow therapeutic index. HSK42360 is next-generation, small-molecule paradox breaker with high It displays significantly less than spares wtBRAF-containing dimers. Treatment results in excellent durable anti-tumor effect...