A5045750001- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Immunodeficiency and Autoimmune Disorders
- MicroRNA in disease regulation
- Antifungal resistance and susceptibility
- Respiratory viral infections research
- Higher Education and Teaching Methods
- Web and Library Services
- Fungal Infections and Studies
- Brain Metastases and Treatment
- Influenza Virus Research Studies
- Ideological and Political Education
- Cerebrospinal fluid and hydrocephalus
- Hepatitis C virus research
- HER2/EGFR in Cancer Research
- Metastasis and carcinoma case studies
- Cancer-related molecular mechanisms research
- Advanced Radiotherapy Techniques
- RNA modifications and cancer
- Environmental and Agricultural Sciences
- Industrial Technology and Control Systems
- Simulation and Modeling Applications
- Pneumonia and Respiratory Infections
- Neuroendocrine Tumor Research Advances
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2025
Children's Hospital of Fudan University
2020-2025
Beijing Hospital
2021-2022
Lianyungang Oriental Hospital
2022
Xuzhou Medical College
2022
Peking Union Medical College Hospital
2014-2021
Cancer Hospital of Chinese Academy of Medical Sciences
2018-2021
National Clinical Research
2021
Genecast (China)
2021
National Kaohsiung Marine University
2017
Lung adenocarcinoma (LAD) is considered to be a highly aggressive disease with heterogeneous prognosis and the molecular mechanisms underlying tumor progression remain elusive. Growing evidence demonstrates that dysregulation of microRNAs (miRNAs) plays an important role in various processes. The aim this study discover prognostic miRNA investigate its involved LAD. Prognosis related was detected by microarray using formalin-fixed paraffin-embedded (FFPE) specimens from 87 patients IIIA-N2...
Abstract Background. Consistent results are lacking as regards the comparative effectiveness of intensity-modulated radiotherapy (IMRT) versus three-dimensional conformal (3DCRT) in patients with locally advanced non-small cell lung cancer (LA-NSCLC). Patients and Methods. treated definitive (RT) between 2002 2010 were retrospectively reviewed. Overall survival (OS), local-regional progression-free (LRPFS), distant metastasis-free (DMFS), (PFS) compared among irradiated different techniques....
Cryptococcus neoformans ( C. )/ gattii can easily invade the human central nervous system and cause cryptococcal meningitis (CM). The clinical fatality rate of these fungi is extremely high causes more than 180,000 deaths worldwide every year. At present, common identification methods are traditional culture Indian ink staining. In addition, enzyme-linked immunosorbent assay (ELISAs), polymerase chain reaction (PCR), real-time quantitative PCR detecting (qPCR), mass spectrometry, metagenomic...
Immune checkpoint inhibitor (ICI) has displayed considerable advantages in consolidation therapy of locally advanced non-small cell lung cancer (LA-NSCLC) after concurrent chemoradiotherapy (cCRT). However, many patients are considered unsuitable for cCRT owing to concerns with tolerability. In this study, we aimed assess the efficacy and toxicity induction immunochemotherapy followed by radiotherapy unresectable LA-NSCLC who not capable receiving cCRT. From January 2019 December 2022,...
Although viral infections are one of the common clinical manifestations in patients with inborn errors immunity (IEIs), little is known about epidemiology, susceptibility genes, and status IEIs. The demographic information, diagnoses, laboratory findings 931 IEI who underwent testing from January 2016 to December 2022 were collected analyzed. In total, 47.15% (439/931) tested positive for at least virus during hospitalization. There a total 640 study period, mainly EBV 131 (20.47%), HRV...
Abstract Background Invasive fungal disease (IFD) is a common complication observed in inborn errors of immunodeficiency (IEI) patients, and little known about the overall prevalence IFD IEI patients. We aimed to summarize spectrum outcomes IFDs Chinese cohort hospitalized patients with IEI. Methods In this retrospective study, 607 from January 2018 June 2022 were included. Demographic, clinical, infection data patient characteristics collected analyzed according classification. Results One...
8059 Background: Recently, several landmark randomized controlled trials on neoadjuvant immunochemotherapy (NIC) have significantly changed the treatment paradigm for locally advanced NSCLC. However, 8.8-19.0% of patients (pts) receiving NIC did not undergo surgery due to various reasons. The strategies and clinical outcomes following stage II-III NSCLC, encompassing both surgical non-surgical approaches, remain unclear. Methods: We conducted a multicenter, retrospective cohort study...
OBJECTIVES: This study aimed to: (1) assess the prognostic significance of serum tumor markers in locally advanced squamous cell carcinoma lung (LA-SCCL); (2) generate a nomogram to predict overall survival (OS) and (3) identify stratification assist therapeutic decision-making. METHODS: LA-SCCL patients receiving definitive radiotherapy baseline marker measurement were eligible for this retrospective study. Cox proportional hazards regression was used determine independent factors...
Abstract Background Esophageal squamous cell carcinoma (ESCC) has unfavorable outcomes with the highest incidence seen in China. Accordingly, exploring effective molecular biomarkers is of great value. MicroRNAs (miRNAs) are posttranscriptional regulators gene expression and modulate numerous biological processes tumors. Our study aimed to identify prognostic miRNAs investigate their role ESCC. Methods Prognosis-related plasma were detected by miRNA microarray qRT-PCR. Functional assays...
<h3>Importance</h3> Treatment of locally advanced non–small cell lung cancer (NSCLC) remains challenging. The rationale combining a cyclooxygenase 2 (COX-2) inhibitor with concurrent chemoradiation (CCRT) was based on results preclinical research and prospective clinical studies; however, no randomized trial has provided evidence direct comparison CCRT alone. <h3>Objective</h3> To determine the effect combined selective COX-2 inhibition standard survival among patients unresectable stage III...
Background: Due to the lack of treatment outcome data comparing surgical and non-surgical modalities in era contemporary staging treatments, management elderly patients with early-stage small cell lung cancer (SCLC) continues be debated. This study sought compare surgery radiotherapy (aged ≥70 years) SCLC using from Surveillance, Epidemiology, End Results (SEER) database. Methods: The inverse probability weighting (IPTW) method was used address selection bias between groups. Kaplan-Meier...
ABSTRACT Purpose This study aimed to compare the efficacy of anlotinib plus whole‐brain radiotherapy (WBRT) with that WBRT alone in non‐small cell lung cancer (NSCLC) patients multiple brain metastases (BMs). Methods The clinical data NSCLC and BMs who received between 2019 2022 were collected. assigned group according treatment used. Results A total 64 eligible for analysis; 21 treated WBRT, 43 WBRT. had a greater proportion young better performance status adenocarcinoma histology than did...
For patients with locally advanced non-small-cell lung cancer (LA-NSCLC), the role of consolidation chemotherapy (CCT) following concurrent chemoradiotherapy (CRT) is partially defined. The aim this study was to evaluate efficacy and toxicity CCT. characteristics LA-NSCLC treated curative CRT from 2001 2010 were retrospectively reviewed. Among 203 patients, 113 (55.7 %) received median number delivered CCT 3 89.4 % completed ≥2 cycles. OS significantly better for in group compared that...
The phosphoinositide-3 kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway plays an important role in cancer progression and treatment, including that small cell lung (SCLC), a disease with traditionally poor prognosis. Given the regulatory microRNA (miRNA) gene expression, we examined association single nucleotide polymorphisms (SNPs) at miRNA-binding sites genes mTOR prognosis patients limited-disease SCLC. A retrospective study was conducted 146 SCLC treated...
A bacterial strain, designated MIB-4T, was isolated from a freshwater spring in Taiwan and characterized using polyphasic taxonomy approach. Cells of strain MIB-4T were Gram-staining-negative, aerobic, non-motile rods that formed pale pink colonies. Growth occurred at 15-30 °C (optimum, 25 °C), pH 7-8 7) with 0-0.5 % NaCl 0 %). Phylogenetic analyses based on 16S rRNA gene sequences showed belonged to the genus Flectobacillus most closely related lacus CL-GP79T sequence similarity 98.7 %....
Congenital neutropenia (CN) is a genetic disorder characterized by persistent or intermittent low peripheral neutrophil counts, thus increasing susceptibility to bacterial and fungal infections. Various forms of CN, caused distinct mutations, exhibit differential responses granulocyte colony-stimulating factor (G-CSF) therapy, with the underlying mechanisms not fully understood. This study presents an in-depth comparative analysis clinical immunological features in 5 CN patient groups...
Abstract Background There is no consensus on the therapeutic approach to ECOG 2 patients with locally advanced non-small-cell lung cancer (LA-NSCLC), despite sizable percentage of these in clinical practice. This study focused efficacy, toxicity and optimal chemotherapy regimen CCRT a phase III trial. Methods Patients capable all self-care bed rest for less than 50% daytime were classified as subgroup. A subgroup analysis was performed recruited trial receiving concurrent EP (etoposide +...