A5029565498- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Cancer Treatment and Pharmacology
- Brain Metastases and Treatment
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Cancer Diagnosis and Treatment
- Cancer Cells and Metastasis
- Advanced Breast Cancer Therapies
- Metastasis and carcinoma case studies
- Glioma Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Estrogen and related hormone effects
- Breast Lesions and Carcinomas
- Medical Imaging Techniques and Applications
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lymphoma Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Advanced Radiotherapy Techniques
- Inflammatory Biomarkers in Disease Prognosis
- Neuroendocrine Tumor Research Advances
- Radiomics and Machine Learning in Medical Imaging
Hebei Medical University
2025
Fourth Hospital of Hebei Medical University
2025
Peking University First Hospital
2019-2025
Peking University
2013-2025
Anhui University
2022
Academy of Military Medical Sciences
2011-2021
King University
2021
Chinese People's Liberation Army
2021
Seagen (United States)
2021
307th Hospital of Chinese People’s Liberation Army
2010-2020
Abstract Tumor-infiltrating T cells recognize, attack, and clear tumor cells, playing a central role in antitumor immune response. However, certain can impair this response help escape. Therefore, exploring the factors that influence T-cell infiltration is crucial to understand immunity improve therapeutic effect of cancer immunotherapy. The use single-cell RNA sequencing (scRNA-seq) allows high-resolution analysis precise composition with different phenotypes other microenvironmental...
Abstract Little is known of the patterns expression ACE2 and TMPRSS2 or clinical characteristics COVID-19 in patients with colorectal cancer. We found both bulk single-cell RNA-seq profiles that were expressed at high levels on tumor normal epithelial tissues. Clinically, cancer more likely to have lymphopenia, higher respiratory rate, hypersensitive C-reactive protein than matched but without These results suggest may be particularly susceptible SARS-CoV-2 infection. Further mechanistic...
Recent advancements in novel antibody-drug conjugates (ADCs) have demonstrated efficacy patients with human epidermal growth factor receptor 2 (HER2)-ultralow breast cancer (BC), expanding the eligibility for anti-HER2 targeted therapy to include some previously categorized as HER2 immunohistochemistry (IHC) 0. This expansion underscores need pathologists accurately differentiate HER2-null and HER2-ultralow. Thirty-six from four centers nationwide conducted microscopic visual assessments on...
// Chunlei Ge 1,* , Shikai Wu 2,* Weiwei Wang 3,* Zhimin Liu 1 Jianhua Zhang Zhenyu 4 Ruilei Li Zhiwei Zhen Suwei Dong Ying Yuanbo Xue Jinyan Yang Qinghua Tan Ziping 5 and Xin Song Department of Cancer Biotherapy Center, The Third Affiliated Hospital Kunming Medical University (Tumor Yunnan Province), Kunming, Yunnan, People's Republic China 2 Radiation Oncology, Academy Military Sciences, Beijing, 3 Thoracic Surgery, Biomedical Engineering Research University, Institute Hospital, Chinese...
This study was initiated to investigate the prognostic significance of circulating tumor cell (CTC) enumeration and predictive value CTC HER2 expression for efficient anti-HER2 therapy in HER2-positive metastatic breast cancer (MBC) patients. Sixty MBC patients were enrolled present study. Before initiation systemic treatment, CTCs from 7.5 ml blood analyzed using CellSearch system. The progression-free survival (PFS) estimated Kaplan-Meier curves. detected 45% (27/60) patients, who had...
This retrospective study investigated the association between hormone receptor (HR) conversion and survival in breast cancer patients.Estrogen (ER) progesterone (PR) status (positive or negative) of primary tumors paired metastatic sites 627 patients were analyzed by McNemar's test for rates conversion. A analysis was performed using Kaplan-Meier method, prognostic factors assessed Cox's proportional hazards regression model.Conversion ER occurred 165 (26.31%) patients, PR 213 (33.97%; P <...
// Chao Liu 1 , Shikai Wu Xiangying Meng Guangxian 2 Dongmei Chen Yang Cong Ge Shen Bing Sun Wei Wang Qian Hongjun Gao 3 and Xiaoqing Department of Radiation Oncology, Affiliated Hospital Academy Military Medical Sciences, Beijing, China Cancer Therapy Center, Lung Cancer, Correspondence to: Wu, email: Keywords : T cells; lymphocyte subsets; stereotactic body radiation therapy; non-small cell lung cancer; immunotherapy Received December 19, 2016 Accepted January 27, 2017 Published February...
Abstract Background Head and neck squamous cell carcinoma (HNSCC) typically present with a complex anatomical distribution, often accompanied by insidious symptoms. This combination contributes to its high incidence poor prognosis. It is now understood that the immune features of cellular components within tumor ecosystem their interactions are critical factors influencing both progression effective response. Methods We obtained single-cell RNA sequencing data 26,496 cells from three tissues...
Out-of-field tumor response, which is also called abscopal effect, bystander or non-target can be regarded as localized irradiation induced systemic antitumorigenic effects, indicating shrinkage of a distant from the irradiated site. Although effect has been documented in several types, it very rare phenomenon clinically reported non-small-cell-lung carcinoma (NSCLC). Herein, we present case patient with NSCLC 2 lesions upper lobe left lung who, after receiving stereotactic ablative...
Treatment strategies are limited for patients with chemotherapy refractory microsatellite stable (MSS) colorectal cancer. We aim to evaluate the efficacy and safety of immune checkpoint inhibitors (ICIs) combined regorafenib in this population routine clinical practice.We retrospectively analyzed advanced or metastatic cancer who received at least one dose ICIs 14 Chinese medical centers. The primary outcome was objective response rate (ORR). This study registered ClinicalTrials.gov on...
Brain metastasis (BM) with a cystic component from breast cancer is rare and largely uncharacterized. The purpose of this study was to identify the characteristics BM in large cohort patients.A total 35 eligible patients 255 solid were analyzed. Three factors significantly associated an increased probability developing lesions: age at diagnosis ≤ 40 years, 45 poor histological grade (p < 0.05). Patients also characterized by larger volume, shorter progression-free survival (PFS) following...
Background Previous studies have documented a high incidence of toxicity in patients with ultra‐central non‐small cell lung cancer (UC‐NSCLC) treated stereotactic body radiation therapy (SBRT). However, these mainly focused on early stage and included small sample populations. We reviewed the outcomes SBRT advanced UC‐NSCLC at our institution. Methods Fifty‐one consecutive using regular regimen 35 Gy administered five fractions between December 2014 August 2017 were reviewed. UC was defined...
Brain metastasis (BM) is common in patients with breast cancer. Predicting patient survival critical for the clinical management of cancer brain (BCBM). The present study was designed to develop and evaluate a prognostic model newly diagnosed BCBM. Based on data BCBM treated Affiliated Hospital Academy Military Medical Sciences (Beijing, China) between 2002 2014, nomogram developed predict using proportional hazards regression analysis. validated internally by bootstrapping, concordance...
Muscle-invasive bladder cancer (MIBC) continues to pose a significant health challenge, as conventional neoadjuvant chemotherapy (NAC) has shown limited improvements in efficacy outcomes. Recent clinical trials suggest that combining NAC with immune checkpoint blockade (NAC.NICB) may enhance therapeutic efficacy. This study aimed explore the short-term and outcomes of NAC.NICB compared real-world settings for treatment MIBC. A total 100 patients MIBC who received either or were included...
Smart gas identification is vital in medical, environmental, and manufacturing fields. However, traditional gas‐sensing technologies either lack portability or demand high working temperatures, devoid of situ instant sensing capability. In this work, Pd‐Au/MXene sensors with excellent properties are fabricated utilizing an growth strategy. A bionic sensor array developed further integrated into platform (IISP). Moreover, machine learning (ML) algorithms employed to strengthen IISP's capacity...
e13061 Background: IMM27M is a humanized Fc-engineered IgG1 CTLA-4 monoclonal antibody with enhanced ADCC. In pre-clinical models, immune responses and promote Treg depletion. The results showed induced significantly stronger anti-tumor activity than ipilimumab resulted in complete tumor remission even at low dose. dose-escalation stage, 25 patients (pts) (20 females, 5 males) were enrolled treated Treatment-related adverse events (TRAEs) occurred 24 pts (96.0%). Most TRAEs (92.2%) grade 1...
3109 Background: Limitations of approved BRAF V600E inhibitors include toxicity from paradoxical activation RAF dimerization as well limited brain penetration. In contrast to agents, investigational pan-RAF both inhibit mutant proteins and wild-type (wt) proteins, leading a narrow therapeutic index. HSK42360 is next-generation, small-molecule paradox breaker with high It displays significantly less than spares wtBRAF-containing dimers. Treatment results in excellent durable anti-tumor effect...
BACKGROUND Patients with microsatellite stable (MSS) metastatic colorectal cancer (mCRC) typically exhibit an immunosuppressive tumor microenvironment and demonstrate a low response rate to immunotherapy. Reports suggest that chemotherapy anti-angiogenic therapy may have the potential enhance immunotherapy in these patients. This study aims evaluate effectiveness safety of combined bevacizumab or without anti-programmed death 1 (PD-1) as second-line regimen for MSS mCRC. AIM To anti-PD-1...
The outcome of recurrent brain metastasis is dismal. This study aims to assess the clinical outcomes and toxicity reirradiation as a salvage treatment for progressive in patients with advanced breast cancer. Between July 2005 September 2014, medical records 56 from cancer were retrospectively reviewed. Of these patients, 39 received whole-brain radiotherapy (WBRT) followed by stereotactic radiosurgery (SRS) (Group 1), 17 SRS WBRT 2). Overall survival (OS) progression-free rates/times...