A5100434757- Nanoparticle-Based Drug Delivery
- Advanced Polymer Synthesis and Characterization
- Nanoplatforms for cancer theranostics
- Electrospun Nanofibers in Biomedical Applications
- Polymer Surface Interaction Studies
- Graphene and Nanomaterials Applications
- RNA Interference and Gene Delivery
- Hydrogels: synthesis, properties, applications
- Tissue Engineering and Regenerative Medicine
- Dendrimers and Hyperbranched Polymers
- Advanced Drug Delivery Systems
- Conducting polymers and applications
- Covalent Organic Framework Applications
- Metal-Organic Frameworks: Synthesis and Applications
- Pluripotent Stem Cells Research
- Advanced biosensing and bioanalysis techniques
- Neuroscience and Neuropharmacology Research
- Glycosylation and Glycoproteins Research
- Wound Healing and Treatments
- Advanced Sensor and Energy Harvesting Materials
- Neurotransmitter Receptor Influence on Behavior
- Antimicrobial agents and applications
- Alzheimer's disease research and treatments
- Advancements in Transdermal Drug Delivery
- Autophagy in Disease and Therapy
Birmingham VA Medical Center
2012-2025
Tianjin University
2016-2025
Agricultural Information Institute
2024-2025
University of Alabama at Birmingham
2008-2025
Shanghai University
2006-2025
University of Cincinnati
1998-2025
Wuhan University of Technology
2025
Chinese Academy of Agricultural Sciences
2024-2025
Sichuan University
2020-2024
Peking University First Hospital
2017-2024
Human pluripotent stem cells (hPSCs) offer the potential to generate large numbers of functional cardiomyocytes from clonal and patient-specific cell sources. Here we show that temporal modulation Wnt signaling is both essential sufficient for efficient cardiac induction in hPSCs under defined, growth factor-free conditions. shRNA knockdown β-catenin during initial stage hPSC differentiation fully blocked cardiomyocyte specification, whereas glycogen synthase kinase 3 inhibition at this...
Abstract Biological tissues generally exhibit excellent anisotropic mechanical properties owing to their well‐developed microstructures. Inspired by the aligned structure in muscles, a highly anisotropic, strong, and conductive wood hydrogel is developed fully utilizing high–tensile strength of natural wood, flexibility high‐water content hydrogels. The exhibits 36 MPa along longitudinal direction due strong bonding cross‐linking between cellulose nanofibers (CNFs) polyacrylamide (PAM)...
Alzheimer's disease (AD) is characterized by a microglial-mediated inflammatory response elicited extensive amyloid deposition in the brain. Nonsteroidal anti-inflammatory drug (NSAID) treatment reduces AD risk, slows progression, and microglial activation; however, basis of these effects unknown. We report that 11-month-old Tg2576 mice overexpressing human precursor protein (APP) with NSAID ibuprofen for 16 weeks resulted dramatic selective reduction SDS-soluble beta-amyloid (Abeta)42,...
A critical regulator of autophagy is the Class III PI3K Vps34 (also called PIK3C3). Although known to play an essential role in yeast, its mammals remains elusive. To elucidate physiological function and determine precise autophagy, we have generated f/f mice, which expression Cre recombinase results a deletion exon 4 frame shift causing 755 887 amino acids Vps34. Acute ablation MEFs upon adenoviral infection diminishment localized generation phosphatidylinositol 3-phosphate blockade both...
Multifunctional and multiresponsive hydrogels have presented a promising platform to design fabricate smart devices for application in wide variety of fields. However, their preparations often involve multistep preparation polymer precursors, tedious reactions introduce functional groups or sophisticated molecular designs. In this work, multifunctional boronic acid-based cross-linker bis(phenylboronic acid carbamoyl) cystamine (BPBAC) was readily prepared from inexpensive commercially...
Flexible porous membranes have attracted increasing scientific interest due to their wide applications in flexible electronics, energy storage devices, sensors, and bioscaffolds. Here, inspired by nature, we develop a facile scalable top-down approach for fabricating superflexible, biocompatible, biodegradable three-dimensional (3D) membrane directly from natural wood (coded as membrane) via one-step chemical treatment. The superflexibility is attributed both physical changes of the wood,...
Using surface-initiated atom transfer radical polymerization (ATRP), block polymers with a series of quaternization degrees were coated on the surface silica nanocapsules (SNCs) by "grafting-from" technique. Molnupiravir, an antiviral medicine urgently approved for treatment SARS-CoV-2, was encapsulated in polymer-coated SNCs and further incorporated into well-defined films polystyrene sulfonate (PSS) homopolymers layer-by-layer (LBL) self-assembly via electrostatic interactions. We...
The block copolymer micelles and natural biopolymers were utilized to form layer-by-layer (LbL) films via electrostatic interaction, which able effectively load controllably release favipiravir, a potential drug for the treatment of coronavirus epidemic. LbL demonstrated reversible swelling/shrinking behavior along with manipulation temperature, could also maintain integrity in structure morphology. Due dehydration environmentally responsive building blocks, rate from was decelerated by...
Homogeneous immunoassays represent an attractive alternative to traditional heterogeneous assays due their simplicity and high efficiency. electrochemical assays, however, are not commonly accessed the requirement of electrode immobilization recognition elements. Herein, we demonstrate a new homogeneous immunoassay based on aggregation-collision strategy for quantification tumor protein biomarker alpha-fetoprotein (AFP). The detection principle relies aggregation AgNPs induced by molecular...
All-perovskite tandem solar cells (APTSCs) offer the potential to surpass Shockley-Queisser limit of single-junction at low cost. However, high-performance APTSCs contain unstable methylammonium (MA) cation in tin-lead (Sn-Pb) narrow bandgap subcells. Currently, MA-free Sn-Pb perovskite (PSCs) show lower performance compared with their MA-containing counterparts. This is due high trap density associated Sn2+ oxidation, which exacerbated by rapid crystallization Sn-containing perovskite....
The application of PEG-b-PCL micelles was dampened by their inherent low drug-loading capability and relatively poor cell uptake efficiency. In this study, a series novel copolymers methoxy poly(ethylene glycol)-b-poly(ε-caprolactone-co-γ-dimethyl maleamidic acid -ε-caprolactone) (mPEG-b-P(CL-co-DCL)) bearing different amounts acid-labile β-carboxylic amides on the polyester moiety were synthesized. chain structure chemical composition characterized (1)H NMR, Fourier transform infrared...
Cardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSCs) are being increasingly used to model heart diseases. hiPSC-CMs generated by earlier aggregation-based methods (i.e., embryoid body) often lack functional sarcoplasmic reticulum (SR) Ca stores characteristic of mature mammalian CMs. Newer monolayer-based cardiac differentiation Matrigel sandwich or small molecule-based differentiation) produce high purity and yield, but their handling has not been comprehensively...