The application of PEG-b-PCL micelles was dampened by their inherent low drug-loading capability and relatively poor cell uptake efficiency. In this study, a series novel copolymers methoxy poly(ethylene glycol)-b-poly(ε-caprolactone-co-γ-dimethyl maleamidic acid -ε-caprolactone) (mPEG-b-P(CL-co-DCL)) bearing different amounts acid-labile β-carboxylic amides on the polyester moiety were synthesized. chain structure chemical composition characterized (1)H NMR, Fourier transform infrared...

Prodrug and drug delivery systems are two effective strategies for improving the selectivity of chemotherapeutics. Molecularly imprinted polymers (MIPs) have emerged as promising carriers in targeted cancer treatment, but they not yet been integrated with prodrug strategy. Reported here is an MIP-based smart system specific targeting, prolonged retention time, tumor microenvironment-triggered release. 5'-Deoxy-5-fluorocytidine (DFCR) sialic acid (SA) were used a marker respectively. Their...

Although protein therapeutics is of significance in therapeutic intervention cancers, controlled delivery proteins still faces substantial challenges including susceptibility to degradation and denaturation poor membrane permeability. Herein, we report a sialic acid (SA)-imprinted biodegradable silica nanoparticles (BS-NPs)-based strategy for targeted cancer therapy. Cytotoxic ribonuclease A (RNase A) was effectively caged the matrix disulfide-hybridized NPs (encapsulation efficiency ∼64%),...

Abstract The glycosylation pattern of alpha fetoprotein (AFP) paves the basis for precise early diagnosis hepatocellular carcinoma (HCC). However, existing analytical methods ignore contribution terminal sialic acid, which has been reported to be highly connected with HCC. Besides, development diagnostic assays is severely hindered by preparation anti‐glycans antibodies. Molecularly imprinted polymers (MIPs), as synthetic antibody mimics, provide unique strengths address these issues....

Accurately analysing the particular glycosylation status of protein biomarkers is significant importance in precise, early diagnosis cancer. Existing methods mainly rely on use antibodies and lectins. However, due to macroscopic microscopic heterogeneity glycans, precise analysis still remains a challenge. Molecularly imprinted polymers (MIPs), as synthetic alternative or lectins, may provide new solutions but have not yet been explored. Herein, we report an appealing strategy called triple...

The VEGF–VEGFR2 (VEGF = vascular endothelial growth factor) signaling has been a promising target in cancer therapy. However, because conventional anti-angiogenic therapeutics suffer from drawbacks, particularly severe side effects, novel strategies are much needed. Herein, we report the rational engineering of VEGF-targeted molecularly imprinted polymer nanoparticles (nanoMIP) for anti-VEGF nanomedicine was prepared via state-of-the-art molecular imprinting approach using N-terminal epitope...

Harnessing innate immunity is an appealing strategy for cancer treatment. Herein, we report a new called molecularly imprinted nanobeacons (MINBs) redirecting immune killing towards triple-negative breast (TNBC). The MINBs were nanoparticles with the N-epitope of glycoprotein nonmetastatic B (GPNMB) as template and grafted plentiful fluorescein moieties hapten. could tag TNBC cells via binding GPNMB thereby provide navigation recruiting hapten-specific antibodies. gathered antibodies further...

Nanoparticle (NP)-assisted drug delivery systems with disassemblable behaviors in response to intracellular microenvironment are urgently demanded systemic cancer chemotherapy for enhanced release. Curcumin (CUR), an effective and safe anticancer agent, was limited by its water insolubility poor bioavailability. Herein, pH reduction dual-induced NPs high loading efficiency improved release of CUR were developed based on acid degradable cyclic benzylidene acetal groups (CBAs)-functionalized...

Chemodynamic therapy (CDT) that kills tumor cells by converting low-reactivity H2O2 into highly toxic hydroxyl radicals (•OH) is an emerging therapeutic modality, but its efficacy largely limited both the lack of targeting and redox homeostasis in cells. Herein, we report Cu2+-encapsulated GalNAc-imprinted biodegradable silica nanoparticles (nanoMIP) for boosting CDT. In this strategy, Cu2+ was first encapsulated disulfide-bridged with a high loading capacity ∼18.3%, followed situ...

Abstract Infectious virus diseases, particularly coronavirus disease 2019, have posed a severe threat to public health, whereas the developed therapeutic and prophylactic strategies are seriously challenged by viral evolution mutation. Therefore, broad‐spectrum inhibitors of viruses highly demanded. Herein, an unprecedented antiviral strategy is reported, targeting glycan shields with hypervalent mannose‐binding nanoparticles. The nanoparticles exhibit unique double‐punch mechanism, being...

Combination delivery systems composed of injectable hydrogels and drug-incorporated micelles or nanoparticles with tunable convenient properties for clinical operation storage are urgently demanded in regional cancer chemotherapy to prolong control drug release, enhance antitumor efficiency decrease side effects. Previously, we developed a novel thermosensitive amphiphilic triblock copolymer, poly(ε-caprolactone-co-1,4,8-trioxa[4.6]spiro-9-undecanone)–poly(ethylene...

A mass spectrometric platform was built for in-depth profiling of mutational landscape cis -diol metabolites from the healthy to primary liver cancer (PLC) patients. This method enabled more precise PLC diagnosis than protein marker-based methods.

Abstract Prodrug and drug delivery systems are two effective strategies for improving the selectivity of chemotherapeutics. Molecularly imprinted polymers (MIPs) have emerged as promising carriers in targeted cancer treatment, but they not yet been integrated with prodrug strategy. Reported here is an MIP‐based smart system specific targeting, prolonged retention time, tumor microenvironment‐triggered release. 5′‐Deoxy‐5‐fluorocytidine (DFCR) sialic acid (SA) were used a marker respectively....

Blocking the PD-1/PD-L1 immune checkpoint has emerged as a promising strategy in cancer immunotherapy, which monoclonal antibodies are predominately used inhibitors. Despite their remarkable success, antibody-based therapeutics suffer from drawbacks due to use of antibodies, such high cost, low stability and frequency immune-related adverse effects. Therefore, novel anti-PD-1/PD-L1 that can address these issues significant importance. Herein, we report molecularly imprinted polymer (MIP)...

Open AccessCCS ChemistryRESEARCH ARTICLE30 Mar 2022High Mannose-Specific Aptamers for Broad-Spectrum Virus Inhibition and Cancer Targeting Wei Li, Shuxin Xu, Ying Jingran Chen, Yanyan Ma Zhen Liu Li State Key Laboratory of Analytical Chemistry Life Science, School Chemical Engineering, Nanjing University, 210023 , Xu Chen *Corresponding author: E-mail Address: [email protected] https://doi.org/10.31635/ccschem.022.202101747 SectionsSupplemental MaterialAboutAbstractPDF ToolsAdd to...

Exploring new targets and developing novel targeted therapies are urgently needed for neuroblastoma therapy. Polysialic acid (polySia), a linear homopolymer of sialic units that correlates well with tumor progression poor prognosis, has emerged as potential target neuroblastoma. However, the lack polySia-specific binding reagents severely limited development polySia-targeting therapeutics Herein, construction nanomissiles via molecular imprinting photothermal therapy is reported. Oligosialic...

Reprogramming tumor-associated macrophages (TAMs) has emerged as a promising strategy in cancer immunotherapy. Targeted therapeutics integrating multiple functions to fully leverage the antitumor immune of without affecting systemic or tissue-resident are crucial for TAM reprogramming. Herein, by molecular imprinting and nanotechnology, we rationally designed engineered an unprecedented nanocoordinator targeted remolding TAMs efficacy inducing cascade effect. The features magnetic iron oxide...

Injectable and biodegradable supramolecular hydrogel mPECT NP/α‐CD gel composed of high‐concentration nanoparticle dispersion (≤20% W/V) α‐cyclodextrins (α‐CD) are prepared by a two‐level physical cross‐linking using amphiphilic block polymer methoxy poly(ethylene glycol)‐ b ‐poly(ε‐caprolactone‐ co ‐1,4,8‐trioxa[4.6]spiro‐9‐undecanone) (mPECT) α‐CD. The gelation behavior depends on the concentration nanoparticles viscoelasticity shear thinning confirmed. In vitro erosion is demonstrated to...

Thermo-sensitive injectable hydrogels based on poly(ε-caprolactone)/poly(ethylene glycol) (PCL/PEG) block copolymers have attracted considerable attention for sustained drug release and tissue engineering applications. Previously, we reported a thermo-sensitive hydrogel of P(CL-co-TOSUO)-PEG-P(CL-co-TOSUO) (PECT) triblock modified by hydrophilic cyclic ether pendant groups 1,4,8-trioxa-[4.6]spiro-9-undecanone (TOSUO). Unfortunately, the low gel modulus PECT (only 50-70 Pa) may limit its...