A5063616750- Effects of Radiation Exposure
- Hematopoietic Stem Cell Transplantation
- Telomeres, Telomerase, and Senescence
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Cancer Research and Treatments
- Sirtuins and Resveratrol in Medicine
- RNA modifications and cancer
- RNA Research and Splicing
- Mesenchymal stem cell research
- Acute Myeloid Leukemia Research
- Genomics, phytochemicals, and oxidative stress
- RNA Interference and Gene Delivery
- Hemoglobinopathies and Related Disorders
- Immune Cell Function and Interaction
- DNA Repair Mechanisms
- Cancer-related molecular mechanisms research
- Cell death mechanisms and regulation
- Cancer-related gene regulation
- Circular RNAs in diseases
- Autophagy in Disease and Therapy
- Cancer-related Molecular Pathways
- Healthcare and Venom Research
- Genomics and Chromatin Dynamics
- Hematological disorders and diagnostics
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2025
Institute of Laboratory Animal Science
2015-2025
Model Animal Research Center
2020
Georgetown University Medical Center
2015
Georgetown University
2015
Tianjin First Center Hospital
2014
Tianjin Medical University
2014
Academy of Medical Sciences
2013
Huainan Normal University
2013
Peking Union Medical College Hospital
2008-2011
Iron overload, caused by hereditary hemochromatosis or repeated blood transfusions in some diseases, such as beta thalassemia, bone marrow failure and myelodysplastic syndrome, can significantly induce injured (BM) function well parenchyma organ dysfunctions. However, the effect of iron overload its mechanism remain elusive. In this study, we investigated effects on hematopoietic stem progenitor cells (HSPCs) from a mouse model. Our results showed that markedly decreased ratio clonogenic...
Exposure to ionizing radiation (IR) increases the production of reactive oxygen species (ROS) not only by radiolysis water but also through IR-induced perturbation cellular metabolism and disturbance balance reduction/oxidation reactions. Our recent studies showed that increased intracellular ROS induced IR contributes late effects, particularly in hematopoietic system, because inhibition with an antioxidant after exposure can mitigate long-term bone marrow (BM) injury. Metformin is a widely...
Abstract Radiation-induced pulmonary fibrosis (RIPF) is a late toxicity of therapeutic radiation in clinic with poor prognosis and limited options. Previous results have shown that senescent cells, such as fibroblast type II airway epithelial cell, are strongly implicated pathology RIPF. However, the role macrophages development RIPF still unknown. In this study, we report ionizing (IR) increase cellular senescence higher expression senescence-associated β-galactosidase (SA-β-Gal)...
Abstract Objectives Transfusional iron overload is of major concern in hematological disease. Iron‐overload‐related dyserythropoiesis and reactive oxygen species (ROS)‐related damage to hematopoietic stem cell (HSC) function are setbacks treatment for such disorders. We therefore aim investigate the effect on hematopoiesis patients explore role ROS iron‐induced oxidative cells microenvironment vitro . Patients methods The colony‐forming capacity level bone marrow were tested before after...
Objective Using a mouse model, Iron Overload (IO) induced bone marrow microenvironment injury was investigated, focusing on the involvement of reactive oxygen species (ROS). Methods Mice were intraperitoneally injected with iron dextran (12.5, 25, or 50mg) every three days for two, four, and six week durations. Deferasirox(DFX)125mg/ml N-acetyl-L-cysteine (NAC) 40mM co-administered. Then, derived mesenchymal stem cells (BM-MSCs) isolated assessed proliferation differentiation ability, as...
Due to improvements in early detection and treatment of cancer, the number long-term cancer survivors is increasing. Unfortunately, these are at increased risk for developing treatment-related late effects, including ionizing radiation (IR)- chemotherapy-induced bone marrow (LT-BM) injury. Because LT-BM injury can deteriorate over time or after patients receiving additional undergoing autologous BM transplantation, it may eventually lead development hypoplastic anemia myelodysplastic...
Nanoparticle (NP)-assisted drug delivery systems with disassemblable behaviors in response to intracellular microenvironment are urgently demanded systemic cancer chemotherapy for enhanced release. Curcumin (CUR), an effective and safe anticancer agent, was limited by its water insolubility poor bioavailability. Herein, pH reduction dual-induced NPs high loading efficiency improved release of CUR were developed based on acid degradable cyclic benzylidene acetal groups (CBAs)-functionalized...
Exposure to a moderate high dose of ionizing radiation (IR) not only causes acute syndrome but also induces long-term (LT) bone marrow (BM) injury. The latter effect IR is primarily attributed the induction hematopoietic stem cell (HSC) senescence. Granulocyte colony-stimulating factor (G-CSF) treatment recommended be given victims soon after IR. However, clinical studies have shown that G-CSF used treat leukopenia induced by radiotherapy or chemotherapy in patients can cause sustained low...
Abstract Exposure of mice to total body irradiation induces nuclear factor κB (NFκB) activation in a tissue-specific manner. In addition the spleen, lymph nodes, and bone marrow, tissues that exhibit NFκB now include newly identified site intestinal epithelial cells. activated by mainly consists p50/RelA heterodimers, genetically targeted disruption p50 gene significantly decreased activation. By comparing tissue damage lethality wild-type knockout (p50−/−) after they were exposed increasing...