A5079604421- Perovskite Materials and Applications
- Conducting polymers and applications
- Telomeres, Telomerase, and Senescence
- Effects of Radiation Exposure
- Quantum Dots Synthesis And Properties
- Generative Adversarial Networks and Image Synthesis
- Advanced Image Processing Techniques
- Chalcogenide Semiconductor Thin Films
- Radiation Therapy and Dosimetry
- PARP inhibition in cancer therapy
- Organic Electronics and Photovoltaics
- Immune cells in cancer
- Natural Language Processing Techniques
- DNA Repair Mechanisms
- Topic Modeling
- Parallel Computing and Optimization Techniques
- Thin-Film Transistor Technologies
- Multimodal Machine Learning Applications
- Digital Media Forensic Detection
- Advanced Vision and Imaging
- Mesenchymal stem cell research
- Cancer-related cognitive impairment studies
- Hematopoietic Stem Cell Transplantation
- Image Enhancement Techniques
- Spaceflight effects on biology
Central South University
2020-2025
China Telecom (China)
2025
China Telecom
2025
Supermicro (United States)
2025
NeoPhotonics (United States)
2025
Nanophoton (Brazil)
2025
Peking University
2005-2024
Shanghai Ocean University
2024
Inner Mongolia University
2024
Southern University of Science and Technology
2020-2022
Cellular senescence suppresses cancer by irreversibly arresting cell proliferation. Senescent cells acquire a proinflammatory senescence-associated secretory phenotype. Many genotoxic chemotherapies target proliferating nonspecifically, often with adverse reactions. In accord prior work, we show that several chemotherapeutic drugs induce of primary murine and human cells. Using transgenic mouse permits tracking eliminating senescent cells, therapy-induced (TIS) persist contribute to local...
Accumulating evidence indicates that senescent cells play an important role in many age-associated diseases. The pharmacological depletion of (SCs) with a "senolytic agent", small molecule selectively kills SCs, is potential novel therapeutic approach for these Recently, we discovered ABT-263, potent and highly selective senolytic agent, by screening library rationally-selected compounds. With this approach, also identified second agent called piperlongumine (PL). PL natural product reported...
Abstract Small molecules that selectively kill senescent cells (SCs), termed senolytics, have the potential to prevent and treat various age-related diseases extend healthspan. The use of Bcl-xl inhibitors as senolytics is largely limited by their on-target dose-limiting platelet toxicity. Here, we report proteolysis-targeting chimera (PROTAC) technology reduce toxicity navitoclax (also known ABT263), a Bcl-2 dual inhibitor, converting it into PZ15227 (PZ), PROTAC, which targets cereblon...
Perovskite solar cells (PSCs) are being rapidly developed at a fiery stage due to their marvelous and fast-growing power conversion efficiency (PCE). Advantages such as high PCE, solution processability, tunable band gaps, flexibility make PSCs one of the research hot spots in energy field. Flexible (f-PSCs) owing power-to-weight ratios can be promising candidates serve sources mobile systems, space portable functional devices, so on. Herein, we give review on recent progress f-PSCs...
With the rapid rise in perovskite solar cells (PSCs) performance, it is imperative to develop scalable fabrication techniques accelerate potential commercialization. However, power conversion efficiencies (PCEs) of PSCs fabricated via two-step sequential deposition lag far behind state-of-the-art spin-coated ones. Herein, additive methylammonium chloride (MACl) introduced modulate crystallization and orientation a doctor-bladed film ambient conditions. MACl can significantly improve quality...
Even as modern computing systems allow the manipulation and distribution of massive amounts information, users these are unable to manage confidentiality their data in a practical fashion. Conventional access control security mechanisms cannot prevent illegitimate use privileged once is granted. For example, information provided by user during an online purchase may be covertly delivered malicious third parties untrustworthy web browser. Existing information-flow do provide this assurance,...
Summary Age‐related bone loss in mice results from a decrease formation and an increase cortical resorption. The former is accounted by the number of postmitotic osteoblasts which synthesize matrix thought to be consequence age‐dependent changes mesenchymal osteoblast progenitors. However, there are no specific markers for these progenitors, conclusions rely on vitro cultures mixed cell populations. Moreover, culprits such remain unknown. Here, we have used Osx1‐Cre;Td RFP osteoprogenitors...
Abstract Rationale Age‐related changes in the intervertebral discs are predominant contributors to back pain, a common physical and functional impairment experienced by older persons. Cellular senescence, process wherein cells undergo growth arrest chronically secrete numerous inflammatory molecules proteases, has been reported cause decline health function of multiple tissues with age. Although senescent have increase degeneration (IDD), it is not known whether they causative age‐related...
Summary The selective depletion of senescent cells ( SC s) by small molecules, termed senolytic agents, is a promising therapeutic approach for treating age‐related diseases and chemotherapy‐ radiotherapy‐induced side effects. Piperlongumine PL ) was recently identified as novel agent. However, its mechanism action molecular targets in s unknown thus investigated. Specifically, we used ‐based chemical probe to pull‐down ‐binding proteins from live then mass spectrometry‐based proteomic...
The toxicity and the instability of lead-based perovskites might eventually hamper commercialization perovskite solar cells. Here, we present optoelectronic properties stability a two-dimensional layered (C6H5CH2NH3)2CuBr4 perovskite. This material has low Eg 1.81 eV high absorption coefficient ∼1 × 105 cm–1 at most intensive 539 nm, implying that it is suitable for light-harvesting in thin film cells, especially tandem Furthermore, X-ray diffraction (XRD), ultraviolet–visible (UV–vis)...
Abstract Flexible perovskite solar cells (f‐PSCs) have been attracting tremendous attention due to their potentially commercial prospects in flexible energy system and mobile system. Reducing the barriers charge extraction losses at interfaces between transport layers is essential improve both efficiency stability of f‐PSCs. Herein, 4‐trifluoromethylphenylethylamine iodide (CF 3 PEAI) introduced form a 2D interface hole layer (HTL). It found that plays dual‐functional role aligning band HTL...
Abstract Mixed‐cation perovskite solar cells (PSCs) have attracted much attention because of the advantages suitable bandgap and stability. It is still a challenge to rationally design modify perovskite/tin oxide (SnO 2 ) heterogeneous interface for achieving highly efficient stable PSCs. Herein, strategy one‐stone‐for‐three‐birds proposed achieve multi‐functional regulation via introducing N‐Chlorosuccinimide (NCS) into solution SnO : i) C═O functional group in NCS can induces strong...
Post-natal human dental pulp stem cells (DPSCs) represent a unique precursor population in the pulp, which has multipotential and can regenerate dentin/pulp-like structure. Because is frequently infected by oral bacteria due to decay, this study, we examined whether lipopolysaccharide (LPS) tumor necrosis factor (TNF) activated immunologic transcription nuclear kappa B (NF-κB) DPSCs. We found that both TNF LPS I-kappa kinase complex (IKK) DPSCs induce phosphorylation degradation of IκBα,...
Abstract Both an increase in osteoclast and a decrease osteoblast numbers contribute to skeletal aging. Markers of cellular senescence, including expression the cyclin inhibitor p16, with aging several bone cell populations. The elimination p16‐expressing cells old mice, using INK‐ATTAC transgene, increases mass indicating that senescent However, identity extent which ablation may prevent remain unknown. Using mice expressing p16‐3MR we examined whether between 12 24 months age could...
Abstract Chemotherapy-induced peripheral neuropathy is among the most common dose-limiting adverse effects of cancer treatment, leading to dose reduction and discontinuation life-saving chemotherapy a permanently impaired quality life for patients. Currently, no effective treatment or prevention available. Senescence induced during has been shown promote effects. Here, we show that cisplatin induces senescent-like neuronal cells in primary culture mouse dorsal root ganglia (DRG), as...
Scaling organic solar cells (OSCs) for commercial use is challenging. High-quality and precise scribing needed to bridge lab-scale large-area OSC modules, but the research lags significantly. Here, we demonstrate a cost-effective patterning approach using 355-nm ultraviolet nanosecond pulsed laser performing all processes, including P1, P2, P3, in fabrication of modules. Optimized processing enables an 80-μm interconnection width, comparable with femtosecond methods, broadens process window...
Simulator development is already a huge burden for many academic and industry research groups; future complex or heterogeneous multi-cores, as well the multiplicity of performance metrics required functionality, will make matters worse. We present new simulation environment, called UNISIM, which designed to rationalize simulator by making it possible efficient distribute overall effort over multiple groups, even without direct cooperation. UNISIM achieves this goal with combination modular...
Due to improvements in early detection and treatment of cancer, the number long-term cancer survivors is increasing. Unfortunately, these are at increased risk for developing treatment-related late effects, including ionizing radiation (IR)- chemotherapy-induced bone marrow (LT-BM) injury. Because LT-BM injury can deteriorate over time or after patients receiving additional undergoing autologous BM transplantation, it may eventually lead development hypoplastic anemia myelodysplastic...
There is an increasing need to better understand the long-term health effects of high-linear energy transfer (LET) radiation due exposure during space missions, as well its use in clinical treatments. Previous studies have indicated that 56Fe heavy ions increases incidence acute myeloid leukemia (AML) mice but underlying molecular mechanisms remain elusive. Epigenetic alterations play a role radiation-induced genomic instability and initiation progression AML. In this study, we assessed...
Uncovering the cellular and molecular mechanisms by which hematopoietic stem cell (HSC) self-renewal is regulated can lead to development of new strategies for promoting ex vivo HSC expansion. Here, we report discovery that alternative (M2)-polarized macrophages (M2-MΦs) promote, but classical (M1)-polarized (M1-MΦs) inhibit, expansion HSCs from mouse bone marrow (BM) in vitro. The opposite effects M1-MΦs M2-MΦs on BM were attributed their differential expression nitric oxide synthase 2...