A5101686384- Viral Infections and Vectors
- Toxoplasma gondii Research Studies
- Herpesvirus Infections and Treatments
- Pulmonary Hypertension Research and Treatments
- Vector-Borne Animal Diseases
- Viral Infections and Outbreaks Research
- interferon and immune responses
- Hippo pathway signaling and YAP/TAZ
- Mesenchymal stem cell research
- Acute Myeloid Leukemia Research
- PI3K/AKT/mTOR signaling in cancer
- Galectins and Cancer Biology
- Mosquito-borne diseases and control
- Cancer-related molecular mechanisms research
- SARS-CoV-2 and COVID-19 Research
- DNA Repair Mechanisms
- Telomeres, Telomerase, and Senescence
- Bone Tissue Engineering Materials
- Parasites and Host Interactions
- Myofascial pain diagnosis and treatment
- Circular RNAs in diseases
- Vector-borne infectious diseases
- MicroRNA in disease regulation
- Research on Leishmaniasis Studies
- Cancer-related Molecular Pathways
Jilin Agricultural University
2013-2025
Hangzhou Medical College
2022-2025
Zhejiang Provincial People's Hospital
2022-2025
Center For Reconstructive Urethral Surgery
2025
Shenzhen Third People’s Hospital
2024
Southern University of Science and Technology
2024
Shanghai University of Traditional Chinese Medicine
2009-2024
Shanghai Second People's Hospital
2024
Fifth Hospital of Shijiazhuang
2024
Hebei Medical University
2020-2024
In 2017, surveillance for tickborne diseases in China led to the identification of a patient who presented hospital Inner Mongolia with febrile illness that had an unknown cause. The clinical manifestation was similar encephalitis virus (TBEV) infection, but neither TBEV RNA nor antibodies against were detected.We obtained blood specimen from index and attempted isolate identify causative pathogen, using genome sequence analysis electron microscopy. We also initiated heightened program same...
Non-structural proteins (NSPs) play a crucial role in the replication of severe acute respiratory syndrome coronavirus 2, facilitating virus amplification and propagation. In this study, we conducted comprehensive investigation into stability all subunits comprising RNA-dependent RNA polymerase complex. Notably, our results reveal for first time that NSP8 is relatively unstable protein, which found to be readily recognized degraded by proteasome. This degradation process mediated host E3...
Infection with Toxoplasma gondii is common and usually asymptomatic, but it can have serious consequences in pregnant women if passed to the developing fetus. The aims of this study were determine prevalence toxoplasmosis identify possible risk factors associated T. infection China. Of a sample 235 Changchun, China, 25 (10.6%) found by ELISA be positive for IgG none (0%) IgM. Major bivariate multivariate analysis include eating raw or undercooked meat, unwashed vegetables fruit, contact...
Abstract Objectives High‐mobility group box‐1 (HMGB1) and aberrant mitochondrial fission mediated by excessive activation of GTPase dynamin‐related protein 1 (Drp1) have been found to be elevated in patients with pulmonary arterial hypertension (PAH) critically implicated PAH pathogenesis. However, it remains unknown whether Drp1‐mediated which downstream targets mediate HMGB1‐induced smooth muscle cells (PASMCs) proliferation migration leading vascular remodelling PAH. This study aims...
Tick-borne rickettsioses are considered important emerging zoonoses worldwide, but their etiological agents, rickettsiae, remain poorly characterized in northeastern China, where many human cases have been reported during the past several years. Here, we determined characteristics of Rickettsia spp. infections ticks this area. Ticks were collected by flagging vegetation from Jilin and Heilongjiang provinces China followed morphological identification. The presence was detected PCR targeting...
Extracellular vesicles are involved in skin wound healing and diabetes.After enrichment identification, plasma endothelial cells-derived-extracellular were cocultured with fibroblasts or HaCaT.The gainand loss-of functions performed to measure fibroblast proliferation, senescence, reactive oxygen species.Levels of senescence-related proteins, senescence-associated secretory phenotypes, vascular markers, YAP the PI3K/Akt/mTOR pathway-related proteins determined.Diabetic mice induced establish...
In Brief Study Design. Rat spinal fusion model. Objective. To compare the efficacy of human adipose tissue-derived mesenchymal stem cells (HATDMSCs) and bone marrow-derived (HBMDMSCs) transduced with an adenovirus containing cDNA for morphogenetic proteins (BMP)-2 inducing in athymic rat Summary Background Data. Recombinant BMPs have successfully induced clinical trials. However, large doses are required adequate repair. Regional gene therapy may deliver to specific anatomic sites more...
There is an increasing need to better understand the long-term health effects of high-linear energy transfer (LET) radiation due exposure during space missions, as well its use in clinical treatments. Previous studies have indicated that 56Fe heavy ions increases incidence acute myeloid leukemia (AML) mice but underlying molecular mechanisms remain elusive. Epigenetic alterations play a role radiation-induced genomic instability and initiation progression AML. In this study, we assessed...
Tick-borne diseases are considered as emerging infectious in humans and animals China. In this study, Ixodes persulcatus (n = 1699), Haemaphysalis concinna 412), longicornis 390), Dermacentor nuttalli 253), silvarum 204) ticks were collected by flagging from northeastern China, detected for infection with Anaplasma, Ehrlichia, Babesia, Hepatozoon spp. using nested polymerase chain reaction assays sequencing analysis. Anaplasma phagocytophilum was all tick species, i.e., I. (9.4%), H. (1.9%),...
Uncovering the cellular and molecular mechanisms by which hematopoietic stem cell (HSC) self-renewal is regulated can lead to development of new strategies for promoting ex vivo HSC expansion. Here, we report discovery that alternative (M2)-polarized macrophages (M2-MΦs) promote, but classical (M1)-polarized (M1-MΦs) inhibit, expansion HSCs from mouse bone marrow (BM) in vitro. The opposite effects M1-MΦs M2-MΦs on BM were attributed their differential expression nitric oxide synthase 2...
Toxoplasma gondii can infect nearly all warm-blooded animals. We report an acute fatal T. infection in the endangered giant panda (Ailuropoda melanoleuca) a zoo China, characterized by gastroenteritis and respiratory symptoms. was confirmed immunological molecular methods. Multilocus nested PCR-RFLP revealed clonal type I at SAG1 c29-2 loci, II SAG2, BTUB, GRA6, c22-8, L358 III alternative SAG2 SAG3 thus, potential new genotype of panda. Other possible pathogens were not detected. To our...
The nucleocapsid protein (NP) plays a crucial role in SARS-CoV-2 replication and is the most abundant structural with long half-life. Despite its vital severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) assembly host inflammatory response, it remains an unexplored target for drug development. In this study, we identified small-molecule compound (ciclopirox) that promotes NP degradation using FDA-approved library drug-screening cell model. Ciclopirox significantly inhibited both...
Heavy metal pollution poses a serious hazard to the soil bacterial community. In this study, 16 s rRNA high-throughput sequencing technology was used analyze diversity and structure of dry field at different levels heavy pollution. Further, relationships between parameters community were analyzed. Based on study findings, we classified in samples from area could be divided into four grades: high risk (HR), considerable (CR), moderate (MR) low (LR). concentrations pH showed significant effect...
BackgroundRecent studies have found that microRNAs (miRNAs) play a critical role in development and progression of intervertebral disc degeneration. In the present study, we examined miR-185 nucleus pulposus cell behavior vitro histological changes tissue degeneration rat models vivo. MethodsIntervertebral were developed Sprague-Dawley rats. Intervertebral was collected for evaluation after agomir/agomir transduction. Next, tissues from lumbar discs to isolate cells, which treated with...
Sphingosine-1-phosphate (S1P), a natural multifunctional phospholipid, is highly increased in plasma from patients with pulmonary arterial hypertension and mediates proliferation of artery smooth muscle cells (PASMCs) by activating the Notch3 signaling pathway. However, mechanisms underpinning S1P-mediated induction PASMCs remain unclear. In this study, using biochemical molecular biology approaches, RNA interference gene expression analyses, 5′-ethynyl-2′-deoxyuridine incorporation assay,...