A5101759974- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Lung Cancer Research Studies
- Nanoparticle-Based Drug Delivery
- MicroRNA in disease regulation
- Pleural and Pulmonary Diseases
- Immune cells in cancer
- Lung Cancer Diagnosis and Treatment
- Nanoplatforms for cancer theranostics
- Glutathione Transferases and Polymorphisms
- Genomics, phytochemicals, and oxidative stress
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Cancer Mechanisms and Therapy
- Cell death mechanisms and regulation
- ATP Synthase and ATPases Research
- Magnesium in Health and Disease
- Respiratory Support and Mechanisms
- Vitamin C and Antioxidants Research
- Ion Channels and Receptors
- Medical Imaging and Pathology Studies
- Insect Utilization and Effects
- Photodynamic Therapy Research Studies
Nanjing Brain Hospital
2022-2025
Shanghai Jiao Tong University
2025
Nanjing Medical University
2018-2025
Yuhuangding Hospital
2025
Qingdao University
2025
Shanghai Ninth People's Hospital
2025
Northeast Forestry University
2024
Anhui Medical University
2024
Icahn School of Medicine at Mount Sinai
2024
First Affiliated Hospital of Anhui Medical University
2024
Abstract Exhausted CD8 + T lymphocytes and tumor-associated macrophages play critical roles in determining cancer prognosis the efficacy of immunotherapy. Our study revealed a negative correlation between exhausted thyroid carcinoma (THCA). Consensus clustering divided patients into two subgroups exhaustion with different prognoses, as defined by marker genes cells. Subsequently, we constructed an eight-gene prognostic signature, developed risk score named exhaustion-related gene (ERGS) to...
Lung cancer remains the most common cause of death for malignancy in both men and women. Current therapies NSCLC patients are inefficient due to lack diagnostic therapeutic markers. The phospho-Ser/Thr-Pro specific prolyl-isomerase Pin1 is overexpressed many different cancers, including NSCLC, may possibly be used as a target therapy. We identified 79 cases with follow-up survival investigated clinical relevance expression patients. To validate oncogenic potential lung cells, we Glc82...
Protein subcellular localization is closely related to protein functions. can work only in specific positions, so a cell very important studies on cytobiology, proteomics, and drug design. prediction based machine learning timely has generated great interest the field of bioinformatics. This paper reviews research status this problem recent years from following four aspects: dataset construction, features extraction sequence, algorithms, web server construction. Finally, we analyzed...
Surgical intervention remains the primary therapeutic modality for managing multiple pulmonary nodules. However, in cases with bilateral nodules, one-stage resection is discouraged due to tumor aggressiveness and surgical invasiveness. In light of this, we investigated an innovative approach, termed nodule via unilateral thoracic cavity access. From July 2022 September 2024, a cohort 12 patients nodules were enrolled this study. This technique involves initial transcostal incision segmental...
Cutaneous myiasis, one of the most frequently diagnosed myiasis types, is defined as skin or soft tissue on a living host infested by dipterous larvae (maggots). However, bibliometric analysis this disease remains sparse. Machine learning techniques and updated publications provide an opportunity for such investigation. All studies were retrieved from PubMed processed using R software in latent Dirichlet allocation (LDA) topic modeling. Furthermore, clinical management two diabetes patients...
AIM:To study the function of N-myc downstream-regulated gene 1 (NDRG1) in colorectal carcinogenesis and its correlation with tumor lymph node metastasis. METHODS:NDRG1 was detected at protein level by immunohistochemistry (IHC) image analysis (IA), NDRG1 mRNA situ hybridization (ISH) formalin-fixed paraffin-embedded sections a total 190 specimens including 38 normal mucosae, 31 adenomas, 45 non-metastatic carcinomas (CRCs), metastatic primary CRC subsequently regional nodes respectively.At...
Assessing the prognosis of patients with early-stage non-small cell lung cancer (NSCLC) has become a major clinical issue. This study aimed to devise an effective nomogram and heat map for assessing survival stage I NSCLC receiving complete resection.Nomograms were established based on retrospective 654 who underwent radical resection at Sun Yat-Sen University Cancer Center between January 2009 December 2014. The concordance index (C-index) calibration curve used measure accuracy...
Background: Gliomas are the most refractory intracranial disease characterized by high incidence and mortality rates. Therefore, radiotherapy plays a crucial role in treatment of gliomas. However, recent evidence reveals that ferroptosis is highly associated with radiosensitivity tumor cells. this study aimed to investigate radiosensitivity- ferroptosis-associated biomarkers. Moreover, provide new strategies for evaluation prognosis Methods: The mRNA sequencing relevant clinical data were...
Gastric cancer (GC) is one of the most frequently diagnosed gastrointestinal types in world. Novel prognostic biomarkers are required to predict progression GC. Glutathione S-transferase Mu (GSTM) belongs a family phase II enzymes that have been implicated number types. However, value GSTM genes has not previously investigated The Cancer Genome Atlas (TCGA) was used evaluate mRNA expression levels GSTMs GC tissue samples. Overall survival (OS) rates, hazard ratios (HRs) and 95% CIs were...
As a molecule controlling the assembly of central spindles and recruitment midzone component, coiled-coil domain-containing protein 69 (CCDC69) plays an important role in multiple cancers. Currently, relationships between CCDC69 immune infiltration or immunotherapy breast cancer remain unclear.The expression prognostic significance were comprehensively analyzed by quantitative real-time PCR, immunohistochemical staining various databases. The data source differentially expressed genes, gene...
The present study elucidated cuproptosis-related molecular clusters involved in ischemic stroke and developed predictive models. Transcriptomic immunological profiles of stroke-related datasets were extracted from the Gene Expression Omnibus database. Next, we conducted weighted gene co-expression network analysis to determine cluster-specific differentially expressed genes (DEGs). Models such as random forest eXtreme gradient boosting (XGB) evaluated select best prediction performance...
Oesophageal squamous cell carcinoma (ESCC) is a malignant tumour of the digestive system that associated with high morbidity and mortality rates worldwide. With increased use immunotherapy in cancer treatment, there an urgent need to elucidate immune-related mechanisms ESCC other carcinomas.In our study, single-sample gene set enrichment analysis (ssGSEA) was first performed analyse expression profile downloaded from NCBI Gene Expression Omnibus (GEO) database. Then, via series bioinformatic...
Purpose: Hypoxia and immune cell infiltration play an important role in the progression metastasis of gastric cancer. However, molecular classification cancer combined with hypoxia remains unknown. Materials Methods: ssGSEA was used to evaluate hypoxic state 1059 samples collected from GEO TCGA database. Based on results, unsupervised clustering performed obtain different subtypes. The differentially expressed genes related OS between these subtypes were utilized for LASSO analysis construct...
Background. Lung squamous cell carcinoma (LUSC) is one of the most common types lung and has specific clinicopathologic characteristics. In this study, we screened novel molecular biomarkers relevant to prognosis LUSC explore new diagnostic treatment approaches for disease. Methods. We downloaded GSE73402 from Gene Expression Omnibus (GEO) database. contains 62 samples, which could be classified as four subtypes according their pathology stages. Via weighted gene coexpression network...
Backgrounds Colorectal adenocarcinoma (COAD), accounting for the most common subtype of colorectal cancer (CRC), is a kind malignant digestive tumor. Some cell cycle checkpoints (CCCs) have been found to contribute CRC progression, whereas functional roles lot CCCs, especially integrated role checkpoint mechanism in cycle, remain unclear. Materials and methods The Genomic Data Commons (GDC) Cancer Genome Atlas (TCGA) COAD cohort was retrieved as training dataset, GSE24551 GSE29623 were...
Background: Primary small cell carcinoma of the esophagus (SCCE) is a rare and extremely fatal disease. We aim to evaluate efficacy radical surgery for resectable SCCE explore potential prognostic factors. Methods: retrospectively reviewed 52 consecutive patients who underwent from February 1993 November 2014 at single institution. The Kaplan-Meier estimator with log-rank test was used assess overall survival (OS), disease-free (DFS) median time. Univariate multivariable analyses were...
Based on a potential shared pathophysiology tied to mast cell activity and neurogenic inflammation that may link pruritus chronic cough (CC), this study, leveraging the
Expression of concern for ‘A hypoxia-dissociable siRNA nanoplatform synergistically enhanced chemo-radiotherapy glioblastoma’ by Yandong Xie, et al. , Biomater. Sci. 2022, 10 6791–6803, https://doi.org/10.1039/D2BM01145J.
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Background: Malignant pleural mesothelioma (MPM) is a malignant tumor originating from mesothelial cells and has high mortality rate worldwide. With the advent of immunotherapy in MPM treatment, there an urgent need to elucidate immune-related mechanisms this caner. Methods: Single-sample gene set enrichment analysis (ssGSEA) was used score immunocytes infiltration data different database sources. Identification immunocyte-related genes performed with weighted co-expression network (WGCNA),...