A5091075235- Dermatology and Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Asthma and respiratory diseases
- IL-33, ST2, and ILC Pathways
- Allergic Rhinitis and Sensitization
- Urticaria and Related Conditions
- Immune Cell Function and Interaction
- Autoimmune Bullous Skin Diseases
- Food Allergy and Anaphylaxis Research
- Rheumatoid Arthritis Research and Therapies
- Neuropeptides and Animal Physiology
- Neurotransmitter Receptor Influence on Behavior
- Antimicrobial Resistance in Staphylococcus
- Adipokines, Inflammation, and Metabolic Diseases
- Statistical Methods and Inference
- Adipose Tissue and Metabolism
- Cancer Immunotherapy and Biomarkers
- Chemotherapy-related skin toxicity
- Immunotherapy and Immune Responses
- Diet and metabolism studies
- Hair Growth and Disorders
- Cytokine Signaling Pathways and Interactions
- Receptor Mechanisms and Signaling
- Biosimilars and Bioanalytical Methods
- Cutaneous Melanoma Detection and Management
Icahn School of Medicine at Mount Sinai
2013-2025
Mount Sinai Medical Center
2023
University of Mississippi
2023
Rockefeller University
2013-2022
Hospital Italiano de Buenos Aires
2008-2022
Rockefeller University Hospital
2017-2022
Leo Pharma (Denmark)
2019-2022
Mount Sinai Hospital
2022
Instituto Nacional de Rehabilitación Psicofísica
2020
Universidade Federal Fluminense
2011-2014
Significance Heart failure (HF) has a high morbidity and mortality its incidence is increasing worldwide. While protein biomarkers have been established for diagnostic prognostic evaluation of patients with HF, there currently no systematic assessment RNA biomarkers. We determined the composition myocardial tissue circulating microRNAs (miRNAs) in large cohort stable advanced HF compared it to normal adult fetal samples. The underwent mechanical unloading left ventricular assist devices...
The validated Research Participant Perception Survey (RPPS-Long) elicits valuable data at modest response rates.To address this limitation, we developed shorter RPPS-Ultrashort and RPPS-Short versions, fielded them with the RPPS-Long to a random sample of national research volunteer registry, assessed completion rates, test/retest reliability, demographics.2228 eligible registry members received survey links. Response rates were 64% (RPPS-Ultrashort), 63% (RPPS-Short), 51% (RPPS-Long),...
Abstract Background The incidence of adult‐onset atopic dermatitis (AOAD) is increasing. However, the unique characteristics AOAD compared to pediatric‐onset AD persisting into adulthood (POAD) are underexplored, hampering development targeted‐therapeutics for this growing population. We thus assessed profile in skin and blood that POAD. Methods collected biopsies from adults with AOAD, POAD, healthy controls ( n = 15 each group). Skin samples were analyzed by RNA sequencing, qRT‐PCR,...
Abstract Background Tralokinumab is a monoclonal antibody that specifically neutralizes interleukin (IL)‐13, key driver of skin inflammation and barrier abnormalities in atopic dermatitis (AD). This study evaluated early 2‐year impacts IL‐13 neutralization on serum biomarkers following tralokinumab treatment adults with moderate‐to‐severe AD. Methods Skin biopsies blood samples were from subset patients enrolled the Phase 3 ECZTRA 1 (NCT03131648) long‐term extension ECZTEND (NCT03587805)...
A fundamental question in human susceptibility to bacterial infections is what extent variability a function of differences the pathogen species or individual humans. To focus on species, we compared same adaptive T and B cell immune response multiple strains two major pathogens, Staphylococcus aureus Streptococcus pyogenes. We found wide acute induced by various with unique combination activation within arms response. Further, this was also accompanied dramatic difference intensity specific...
Obesity is associated with subclinical white adipose tissue inflammation, as defined by the presence of crown-like structures (CLSs) consisting dead or dying adipocytes encircled macrophages. In humans, bariatric surgery-induced weight loss leads to a decrease in CLSs, but effects rapid diet-induced on CLSs and metabolism are unclear. To determine very-low-calorie CLS density, systemic biomarkers obese postmenopausal women. Prospective cohort study. Rockefeller University Hospital, New York,...
Objective: Toll-like receptor-3 agonist Poly-ICLC has been known to activate immune cells and induce HIV replication in pre-clinical experiments. In this study we investigated if could be used for disrupting latency while simultaneously enhancing innate responses. Design: This was a randomized, placebo-controlled, double-blinded trial aviremic, cART-treated HIV-infected subjects. Participants (n=15) were randomized 3:1 receive two consecutive daily doses of (1.4mg subcutaneously) versus...
Background Vitiligo is an autoimmune depigmenting disorder with no effective and safe treatments. Its pathogenesis not fully elucidated. Objective This substudy of a randomized, double-blind, placebo-controlled phase 2b trial (NCT03715829) evaluated effects ritlecitinib, oral JAK3/TEC family kinase inhibitor, on skin blood biomarkers in participants non-segmental vitiligo (NSV). Methods 65 adults NSV participated the received daily treatment for 24 weeks placebo (n=14) or ritlecitinib...
Background and Aim:The metabolic syndrome (MetS) is a pathological condition comprised of abdominal obesity, insulin resistance, hypertension, hyperlipidemia.It has become major threat globally, resulting in rapidly increasing rates diabetes, coronary heart disease, stroke.The polyphenol resveratrol (RES) believed to improve glucose homeostasis resistance by activating sirtuin, which acetylates coactivates downstream targets affects lipid the liver, secretion pancreas, uptake skeletal...
Pruritus is the most common and burdensome symptom of atopic dermatitis (AD). Pruritus-targeted treatments in AD are lacking, particularly for patients with milder skin disease.We sought to evaluate impact selective κ-opioid receptor agonist difelikefalin (DFK) on pruritus intensity pruritus- immune-related biomarkers subjects moderate severe AD-related pruritus.A phase 2 clinical trial investigated efficacy safety oral DFK 0.25, 0.5, 1.0 mg pruritus. A biomarker substudy evaluated effects...
Abstract Background RPT193 is an orally administered small molecule antagonist of the human C‐C motif chemokine receptor 4 (CCR4) that inhibits migration and downstream activation T‐helper Type 2 (Th2) cells. We investigated single‐ multiple‐ascending doses in healthy subjects, multiple subjects with moderate‐to‐severe atopic dermatitis (AD). Methods This was a first‐in‐human randomized, placebo‐controlled Phase 1a/1b monotherapy study (NCT04271514) to evaluate safety, tolerability,...
Abstract Background This is the first report on effects of abrocitinib, a Janus kinase 1–selective inhibitor, expression skin biomarkers in patients with moderate‐to‐severe atopic dermatitis (AD). Methods JADE MOA (NCT03915496) was double‐blind Phase 2a trial. Adults were randomly assigned 1:1:1 to receive monotherapy once‐daily abrocitinib 200 mg, 100 or placebo for 12 weeks. The primary endpoint change from baseline markers inflammation (matrix metalloproteinase [MMP]‐12), epidermal...
We analysed the antimicrobial susceptibility, biofilm formation and genotypic profiles of 27 isolates Staphylococcus haemolyticus obtained from blood 19 patients admitted to a hospital in Rio de Janeiro, Brazil. Our analysis revealed clinical significance 36.8% multi-resistance rate 92.6% among these isolates. All but one isolate carried mecA gene. The staphylococcal cassette chromosome mec type I was most prevalent element detected (67%). Nevertheless, showed clonal diversity based on...