A5101604944- Neuroscience and Neuropharmacology Research
- Photoreceptor and optogenetics research
- Tryptophan and brain disorders
- Cancer, Hypoxia, and Metabolism
- Big Data and Business Intelligence
- Natural product bioactivities and synthesis
- Angiogenesis and VEGF in Cancer
- Neuroscience and Neural Engineering
- Cancer-related gene regulation
- Sperm and Testicular Function
- Cancer Cells and Metastasis
- Memory and Neural Mechanisms
- Wnt/β-catenin signaling in development and cancer
- Neuroendocrine Tumor Research Advances
- Cancer-related cognitive impairment studies
- IgG4-Related and Inflammatory Diseases
- Peroxisome Proliferator-Activated Receptors
- Cancer and Skin Lesions
- Neural dynamics and brain function
- Fatty Acid Research and Health
- Breast Lesions and Carcinomas
- Laser-Matter Interactions and Applications
- Cancer Genomics and Diagnostics
- Pluripotent Stem Cells Research
- Axon Guidance and Neuronal Signaling
Shanghai Jiao Tong University
2024-2025
Shanghai Ninth People's Hospital
2025
Kaohsiung Chang Gung Memorial Hospital
2013-2024
National Sun Yat-sen University
2024
Chang Gung University
2013-2024
Huazhong University of Science and Technology
2024
Data Assurance and Communication Security
2024
Xi'an Jiaotong University
2024
Sichuan Academy of Traditional Chinese Medicine
2024
University of Hong Kong
2018-2024
Highlights•We established a system to generate hiPSC-derived hepatobiliary organoids in vitro.•To varying degrees, this model recapitulated several key aspects of organogenesis.•The displayed series hepatic and biliary functional attributes.•This does not rely on any exogenous cells or genetic manipulation.Graphical abstractAbstractBackground & AimsHuman induced pluripotent stem cell (hiPSC)-derived liver modeling systems have the potential overcome shortage donors for clinical application...
Significance Connections are crucial to brain function and a variety of molecular systems direct axonal growth during development regeneration. An important system involves Celsr2, Celsr3, Fzd3, membrane proteins that also regulate epithelial planar cell polarity (PCP). Here, we show genetically Celsr2 Celsr3 guide axons redundantly, in collaboration with Fzd3 the same populations. However, unlike PCP, their action is Vangl1 Vangl2 independent. Furthermore, expression Celsr2-3...
Abstract Stress is a major risk factor for the onset of many psychiatric diseases. In rodent models, chronic stress induces depression and impairs excitatory neurotransmission. However, little known about effect on synaptic circuitry during development behavioral symptoms. Using two-photon transcranial imaging, we studied repeated restraint dendritic spine plasticity in frontal cortex vivo. We found that induced loss by decreasing rate formation increasing elimination. The N -methyl- d...
Celsr3 and Fzd3 regulate the development of reciprocal thalamocortical projections independently their expression in cortical or thalamic neurons. To understand this cell non autonomous mechanism further, we tested whether could act via Isl1-positive guidepost cells. cells appear forebrain at embryonic day (E) 9.5-E10.5 and, from E12.5, they form 2 contingents ventral telencephalon prethalamus. In control mice, corticothalamic axons run telencephalic corridor close contact with When is...
Abstract An ideal vascular stent would both inhibit in‐stent restenosis (ISR) and promote rapid re‐endothelialization. In the current study, performance of arsenic trioxide (ATO)‐drug eluting (AES) is compared with bare metal stent, poly‐lactic‐ co ‐glycolic acid–coating rapamycin‐drug (RES). vivo AES shown to prevent neointimal hyperplasia more efficiently than others when implanted into carotid arteries rabbits. Moreover, promotes endothelial cells proliferation re‐endothelialization...
Kinesin 1 (KIF5) is one major type of motor protein in neurons, but its members' function the intact brain remains less studied. Using vivo two-photon imaging, we find that conditional knockout Kif5b (KIF5B cKO) CaMKIIα-Cre-expressing neurons shows heightened turnover and lower stability dendritic spines layer 2/3 pyramidal with reduced spine postsynaptic density 95 acquisition mouse cortex. Furthermore, RNA-binding fragile X mental retardation (FMRP) translocated to proximity newly formed...
Advanced strategies to interconvert cell types provide promising avenues model cellular pathologies and develop therapies for neurological disorders. Yet, methods directly transdifferentiate somatic cells into multipotent induced neural stem (iNSCs) are slow inefficient, it is unclear whether pass through a pluripotent state with full epigenetic reset. We report iNSC reprogramming from embryonic aged mouse fibroblasts as well human blood using an engineered Sox17 (eSox17FNV). eSox17FNV...
SOX2 is a key regulatory gene in embryonic stem cells. Although it has been implicated cancer progression, its role breast carcinoma poorly understood.Fifty-seven ductal carcinomas situ (DCIS), 552 invasive and 107 corresponding metastatic lymph nodes were evaluated immunohistochemically for the expression of SOX2. Its correlation with clinicopathological features, other biomarker profiles patients' outcomes analysed.SOX2 was detected 19.0% (105 552) 12.3% (seven 57) DCIS. Expression...
Cutaneous myiasis, one of the most frequently diagnosed myiasis types, is defined as skin or soft tissue on a living host infested by dipterous larvae (maggots). However, bibliometric analysis this disease remains sparse. Machine learning techniques and updated publications provide an opportunity for such investigation. All studies were retrieved from PubMed processed using R software in latent Dirichlet allocation (LDA) topic modeling. Furthermore, clinical management two diabetes patients...
Aims Many immunohistochemical markers have been studied for differentiating papillary lesions. However, their power has not evaluated comprehensively. Additionally, assessment of some will require the difficult task identifying different cell types. In current study, we aimed to devise a simple panel which can aid in diagnosis irrespective architectural pattern and type differentiation. Methods results Immunohistochemical analysis lesions using myoepithelial [p63 smooth muscle actin (SMA)],...
In this study, 4 different spermatic vein ligation procedures for varicocele (VC) treatment were compared based on recurrence rate, postoperative complications, and semen quality. Between January 2012 May 2013, a total of 345 male patients with VC recruited at The First Affiliated Hospital Soochow University. Patients performed by procedures, they divided into groups: laparoscopic varicocelectomy group (LV group: n = 84), microscopic inguinal (MIV 85), retroperitoneal (MRV 86), subinguinal...
Primate-specific DAZ (deleted in azoospermia) has evolved the azoospermia factor c (AZFc) locus on Y chromosome. Loss of is associated with patients deletion AZFc region (AZFc_del). However, molecular mechanisms spermatogenesis remain uncertain. In this study, mechanism identified, which unknown since it identified 40 years ago because lack a suitable model. Using clinical samples and cell models, shown that plays an important role loss defective proliferation c-KIT-positive spermatogonia...
Nonlinear photoinduced anisotropy in a bacteriorhodopsin film was theoretically and experimentally investigated broadband active optical limiter demonstrated the visible spectral range. A diode-pumped second harmonic yttrium aluminum garnet laser used as pumping beam three different wavelengths at λ=442, 532, 655nm from lasers were probing beams. The pump probe beams overlap sample. When is absent, cannot transmit crossed polarizers. With presence of beam, portion light detected owing to...
Systemic inflammation has emerged as a key pathophysiological process that induces multiple organ injuries and causes serious human diseases. Despite substantial evidence supporting the role of diacylglycerols (DAG) in modulating chronic diseases, potential mechanisms its involvement TLRs-mediated are still unclear. Here, we show sn-1,2-diacylglycerols modulate LPS/TLR4-mediated vitro vivo. ELISA western blotting experiments indicated suppress LPS-induced responses, including IL-6 TNF-α...
<b><i>Background:</i></b> The aim of this study was to ascertain the clinical manifestations granulomatosis with polyangiitis (Wegener's) (GPA) involvement peripheral nervous system (PNS) and central (CNS). <b><i>Summary:</i></b> All neurologic inpatients in a hospital over 12-year period were reviewed. Nine patients met both ACR 1990 traditional format criteria for classification GPA Chapel Hill nomenclature mandatory GPA. We focused on...
The aim of this study was to investigate whether fermented Platycodon grandiflorum (FPG) inhibits lipid accumulation in 3T3-L1 adipocytes and mice with high-fat diet (HFD)-induced obesity. We evaluated the effect FPG on antiadipogenic activity via regulation peroxisome proliferator-activated receptor gamma (PPARγ) CCAAT/enhancer-binding protein alpha (C/EBPα), as well expression their target genes, fatty acid binding 4 (FABP4). further examined antiobesity effects HFD-induced obesity mice....
Here, we present an uncommon case of inflammatory myofibroblastic tumor (IMT) involving the mesentery. The was composed loosely arranged round-to-spindle-shaped cells with amphophilic cytoplasm in and myxoid background. mitotic activity low (1 per 50 high-power fields) lacked cellular atypism. Immunohistochemically, demonstrated strong nuclear membranous staining anaplastic lymphoma kinase (ALK). In situ hybridization for ALK gene rearrangement revealed a splitting apart two signals within...