A5006158257- Galectins and Cancer Biology
- Immune Cell Function and Interaction
- Heat shock proteins research
- Animal Nutrition and Physiology
- MicroRNA in disease regulation
- Immunotherapy and Immune Responses
- Ubiquitin and proteasome pathways
- Hepatitis B Virus Studies
- Cancer-related molecular mechanisms research
- Endoplasmic Reticulum Stress and Disease
- RNA Interference and Gene Delivery
- Inflammatory Biomarkers in Disease Prognosis
- Protein Degradation and Inhibitors
- RNA modifications and cancer
- T-cell and B-cell Immunology
- Dermatology and Skin Diseases
- Circular RNAs in diseases
- Hepatitis C virus research
- Acute Myeloid Leukemia Research
- Cell death mechanisms and regulation
- Pharmacological Effects of Natural Compounds
- Ginger and Zingiberaceae research
- Cancer-related gene regulation
- Reproductive System and Pregnancy
- Phagocytosis and Immune Regulation
Guangxi Academy of Agricultural Science
2021-2025
Huazhong University of Science and Technology
2008-2025
Union Hospital
2025
Shandong Provincial Hospital
2010-2024
Shandong First Medical University
2023-2024
Nanjing University of Chinese Medicine
2020-2023
First Bethune Hospital of Jilin University
2017-2023
First Hospital of Jilin University
2016-2023
Jilin University
2013-2023
Institute of Microbiology
2010-2023
As the most abundant liver-specific microRNA, miR-122 is involved in diverse aspects of hepatic function and neoplastic transformation. Our previous study showed that levels are significantly decreased hepatitis B virus (HBV)-infected patients, which may facilitate viral replication persistence (S. Wang, L. Qiu, X. Yan, W. Jin, Y. Chen, E. Wu, Ye, G. F. Gao, Z. Duan, S. Meng, Hepatology 55:730-741, 2012). Loss expression patients with enhances through cyclin G1-modulated P53 activity.). In...
Significance The bromodomain and extraterminal domain (BET) proteins regulate transcription of subset-specifying genes during lineage-specific T-helper-cell differentiation in adaptor immunity are also implicated inflammatory disorders. available pan-BET inhibitors such as JQ1 indiscriminately block the tandem bromodomains (BD1 BD2) BET proteins, broadly render different Th subsets, have limited therapeutic potential. Here we report a small molecule, MS402, that can selectively inhibit BD1...
Abstract More than 350 million people are chronically infected with hepatitis B virus, and dysfunctional T cell responses contribute to persistent viral infection immunopathogenesis in chronic (CHB). However, the underlying mechanisms of hyporesponsiveness remain largely undefined. Given important role microRNA-146a (miR-146a) diverse aspects lymphocyte function, we investigated potential mechanism miR-146a regulating immune CHB. We found that expression cells is significantly upregulated...
Persistent inflammation in chronic hepatitis plays a major role the development of hepatocellular carcinoma (HCC). In this study, inflammatory cytokines expressed hepatitis, IL-6 and TNF-α, induced marked decrease microRNA-122 (miR-122) levels, miR-122 expression was downregulated livers B (CHB) patients. The caused upregulation proinflammatory chemokine CCL2. TNF-α suppressed both by directly downregulating transcription factor C/EBPα indirectly upregulating c-myc, which blocks...
Increasing attention is focused on the relationship of inflammation biomarkers with malignant tumors. The purpose present study was to detect whether preoperative red distribution width (RDW) and platelet (PDW) can be used distinguish patients gastric cancer (GC) or early stage GC from healthy controls predict progression prognosis GC. RDW PDW values 227 164 were retrospectively analyzed comparing 101 controls. In addition, clinicopathological features, survival curves compared between high...
The T-cell immunoglobulin- and mucin-domain-containing molecules (TIMs) comprise a new family of cell surface expressed on T cells. TIM-3 is helper type 1 (Th1) cells implicated in the pathogenesis Th1-driven auto- allo-immune diseases. TIM-1 suggested to act as co-stimulatory molecule for all cells, but with potentially stronger effects Th2 than Th1 associated Th2-related immune However, TIM have not been investigated systemic lupus erythematosus (SLE). In this study, we examined expression...
Objectives Research on the relationship between inflammatory biomarkers and malignant tumors has become a hotspot. Many studies have demonstrated that neutrophil‐lymphocyte ratio ( NLR ), platelet‐lymphocyte PLR red blood cell distribution width RDW ) could act as independent prognostic indicators for several solid tumors. This study aimed to evaluate clinical implications of pretreatment biomarkers, including , in prostate cancer PC a). Methods A total 226 patients who were diagnosed at our...
Protein subcellular localization is closely related to protein functions. can work only in specific positions, so a cell very important studies on cytobiology, proteomics, and drug design. prediction based machine learning timely has generated great interest the field of bioinformatics. This paper reviews research status this problem recent years from following four aspects: dataset construction, features extraction sequence, algorithms, web server construction. Finally, we analyzed...
Abstract Jumonji domain-containing protein 6 (JMJD6) is a member of the C family Fe(II) and 2-oxoglutarate (2OG) dependent oxygenases. It possesses unique bi-functional oxygenase activities, acting as both an arginine demethylase lysyl-hydroxylase. JMJD6 has been reported to be over-expressed in oral, breast, lung, colon cancers plays important roles regulation transcription through interactions with regulator BRD4, histones, U2AF65, Luc7L3, SRSF11. Here, we report structural mechanism...
Abstract The Citri Reticulatae Pericarpium (CRP), is the aged peel of Citrus fruit, which contains phenols, flavonoids, and polysaccharides. This study aims to investigate dietary CRP supplementation on growth performance, serum biochemical indices, meat quality, intestinal morphology, microbiota, metabolite yellow‐feathered broilers. A total 240 broilers (1.00 ± 0.22 kg, 9 weeks old) were randomly allotted into 4 treatments feeding a basal diet (control), containing antibiotics (positive...
The study evaluated the effects of Pleurotus geesteranus stem (PGS), an agricultural waste rich in bioactive components, on pig growth, antioxidant status, anti-inflammatory responses, short-chain fatty acid (SCFA) production, fecal microbiota, intestinal function, and meat quality across different stages. In Exp. 1, 108 weaned piglets (7.80 ± 0.41 kg) were randomly assigned to three dietary treatments: control (basal diet), 1.5% PGS, 3% PGS. 2, growing-finishing pigs (76.97 5.91 subjected...