A5019466654- Immune Cell Function and Interaction
- interferon and immune responses
- Immunotherapy and Immune Responses
- Heat shock proteins research
- Hepatitis B Virus Studies
- MicroRNA in disease regulation
- Toxin Mechanisms and Immunotoxins
- Clostridium difficile and Clostridium perfringens research
- Cancer-related molecular mechanisms research
- Viral gastroenteritis research and epidemiology
- Endoplasmic Reticulum Stress and Disease
- CAR-T cell therapy research
- Cerebrovascular and Carotid Artery Diseases
- Hepatitis C virus research
- Cancer Immunotherapy and Biomarkers
- Inflammasome and immune disorders
- RNA Interference and Gene Delivery
- Virus-based gene therapy research
- Ultrasound and Hyperthermia Applications
- Escherichia coli research studies
- Cardiovascular Disease and Adiposity
- RNA modifications and cancer
- Immune Response and Inflammation
- Ubiquitin and proteasome pathways
- Immune cells in cancer
First Affiliated Hospital of Bengbu Medical College
2019-2025
Anhui University of Traditional Chinese Medicine
2025
Bengbu Medical College
2025
Hefei University of Technology
2025
The Ohio State University
2021-2024
Northeast Institute of Geography and Agroecology
2023-2024
Chinese Academy of Sciences
2010-2024
University of Chinese Academy of Sciences
2020-2024
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2024
Changchun Institute of Optics, Fine Mechanics and Physics
2024
Abstract More than 350 million people are chronically infected with hepatitis B virus, and dysfunctional T cell responses contribute to persistent viral infection immunopathogenesis in chronic (CHB). However, the underlying mechanisms of hyporesponsiveness remain largely undefined. Given important role microRNA-146a (miR-146a) diverse aspects lymphocyte function, we investigated potential mechanism miR-146a regulating immune CHB. We found that expression cells is significantly upregulated...
Mitochondria, a highly metabolically active organelle, have been shown to play an essential role in regulating innate immune function. Mitochondrial Ca
Abstract Introduction As one of the major components tumor microenvironment, tumor-associated macrophages (TAMs) possess profound inhibitory activity against T cells and facilitate escape from immune checkpoint blockade therapy. Converting this pro-tumorigenic toward anti-tumorigenic phenotype thus is an important strategy for enhancing adaptive immunity cancer. However, a plethora mechanisms have been described differentiation in cancer, metabolic switches to program property TAMs are...
The O -GlcNAc transferase (OGT) is an essential enzyme that mediates protein -GlcNAcylation, a unique form of posttranslational modification many nuclear and cytosolic proteins. Recent studies observed increased OGT -GlcNAcylation levels in broad range human cancer tissues compared to adjacent normal tissues, indicating universal effect promoting tumorigenesis. Here, we show for tumor growth immunocompetent mice by repressing the cyclic GMP-AMP synthase (cGAS)-dependent DNA sensing pathway....
Microplastics (MPs), recognized as an emerging environmental menace, have been extensively investigated in both marine and terrestrial fauna. This study is comprehensive to investigate how polystyrene (PS) affects ruminant animals. The experimental design comprised 24 individually housed lambs, divided into a CON group (diet without PS) three PS-exposed (25 μm, 50 100 μm) groups, each with six the exposure of PS was mg/day, duration 60 days. yielded noteworthy results: (ⅰ) leads decrease...
Non‑alcoholic fatty liver disease (NAFLD) is one of the most common chronic diseases worldwide. Increasing evidence has shown that microRNAs (miRNAs) play a vital role in progression NAFLD. The aim present study was to examine expression level and roles miR‑146a high‑fat diet (HFD) ob/ob mice acid‑treated hepatic cells using RT‑qPCR western blot analysis. results showed significantly decreased livers free acid‑stimulated by RT‑qPCR. Overexpression improved glucose insulin tolerance as well...
Abstract Background Neutrophil-based drug delivery system possesses excellent advantages in targeting at tumour because neutrophils are easily recruited by chemotactic factor tumor microenvironment. Herein, we developed a novel tactic of multistage neutrophils-based nanoparticle for promoting photothermal therapy (PTT) lung cancer. Results Au nanorod (AuNR) was successfully modified with bovine serum albumin (AuNRB) and further conjugated RGD (AuNRBR), followed neutrophil internalisation to...
Abstract The maturation process of natural killer (NK) cells, which is regulated by multiple transcription factors, determines their functionality, but few checkpoints specifically targeting this have been thoroughly studied. Here we show that NK-specific deficiency glucose-regulated protein 94 (gp96) leads to decreased NK cells in mice. These gp96-deficient exhibit undermined activation, cytotoxicity and IFN-γ production upon stimulation, as well weakened responses IL-15 for cell...
Head and neck squamous cell carcinoma (HNSCC) is a prevalent malignancy with high mortality, effective treatment strategies remain limited. This study investigated the effects of benzethonium chloride (BZN), an FDA-approved anti-infective agent, on HNSCC lines its underlying mechanisms. BZN significantly inhibited proliferation CAL27 FaDu induced apoptosis in both vitro. In subcutaneous tumor model, markedly suppressed growth mouse line MOC1. Mechanistically, may directly bind to SH2 domain...
Abstract Although the roles of long non‐coding RNA (lncRNA) ANRIL (Antisense in INK4A locus) have been established various tumors, its mitochondrial metabolic reprogramming hepatocellular carcinoma (HCC) cells are still unclear. This work aims to explore lncRNA regulating liver cancer cells. First, we found that lncRAN expression was significantly increased HCC tissues or compared with normal adjacent and Functional experiment showed overexpression promoted function cells, evident by DNA...
The O -GlcNAc transferase (OGT) is an essential enzyme that mediates protein -GlcNAcylation, a unique form of posttranslational modification many nuclear and cytosolic proteins. Recent studies observed increased OGT -GlcNAcylation levels in broad range human cancer tissues compared to adjacent normal tissues, indicating universal effect promoting tumorigenesis. Here, we show for tumor growth immunocompetent mice by repressing the cyclic GMP-AMP synthase (cGAS)-dependent DNA sensing pathway....
A major challenge for designing prophylactic cancer vaccines is to define immunogenic and safe antigens. Given the striking similarity of antigen expression patterns between embryonic tissues, we defined a prototype strategy using placenta-derived heat shock protein gp96, which induces anti-tumor T cell responses. Immunization with placental gp96 provided partial protection long-term (at least 3 months) immunity against growth transplantable melanoma or breast tumors in mice, elicited total...
The heat shock protein gp96 elicits specific T cell responses to its chaperoned peptides against cancer and infectious diseases in both rodent models clinical trials. Although gp96-induced innate immunity, via a subset of Toll like receptors (TLRs), adaptive through antigen presentation, are believed be important for priming potent responses, direct evidence the role gp96-mediated TLR activation related functional is lacking. Here, we report that containing mutations TLR-binding domain...
Cytotoxic T cells (CTLs) play a key role in the control of Hepatitis B virus (HBV) infection and viral clearance. However, most identified CTL epitopes are derived from HBV genotypes A D, few have been defined C which more prevalent Asia. As core protein (HBc) is conservative immunogenic component, this study we used an overlapping 9-mer peptide pool covering HBc to screen identify specific epitopes. An unconventional HLA-A2-restricted epitope HBc141–149 was discovered structurally...