A5113671493- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Circular RNAs in diseases
- RNA Research and Splicing
- Genetic factors in colorectal cancer
- DNA Repair Mechanisms
- Gut microbiota and health
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Diet and metabolism studies
- Cell Image Analysis Techniques
- Single-cell and spatial transcriptomics
- Analytical chemistry methods development
- Colorectal Cancer Screening and Detection
- HVDC Systems and Fault Protection
- Cancer Mechanisms and Therapy
- Acupuncture Treatment Research Studies
- Pregnancy and Medication Impact
- Gallbladder and Bile Duct Disorders
- Advancements in Transdermal Drug Delivery
- Biosensors and Analytical Detection
- Distributed and Parallel Computing Systems
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2025
Tianjin University of Traditional Chinese Medicine
2025
Harbin Medical University
2025
Ningbo No. 2 Hospital
2019-2024
Chaohu Hospital of Anhui Medical University
2024
Guangzhou University of Chinese Medicine
2024
Guiyang University
2024
Capital University
2018-2023
Second Hospital of Shanxi Medical University
2019-2023
Shanxi Medical University
2023
Circular RNAs (circRNAs) are emerging as a new class of endogenous and regulatory noncoding in latest years. With the widespread application RNA sequencing (RNA-seq) technology bioinformatics prediction, large numbers circRNAs have been identified. However, at present, we lack comprehensive characterization all these interested samples. In this study, integrated 87 935 sequences that cover most identified till now represented circBase to design microarray probes targeting back-splice site...
Recent studies have suggested that microRNA biomarkers could be useful for stratifying lung cancer subtypes, but signatures varied between different populations. Squamous cell carcinoma (SCC) is one major subtype of urgently needs to aid patient management. Here, we undertook the first comprehensive investigation on in Chinese SCC patients.MicroRNA expression was measured cancerous and noncancerous tissue pairs strictly collected from patients (stages I-III), who had not been treated with...
Abstract Background Increasing evidence supports the role of small nucleolar RNAs (snoRNAs) and long non-coding (lncRNAs) as master gene regulators at epigenetic modification level. However, underlying mechanism these functional ncRNAs in colorectal cancer (CRC) has not been well investigated. Methods The dysregulated expression profiling lncRNAs-snoRNAs-mRNAs their correlations co-expression enrichment were assessed by GeneChip microarray analysis. candidate lncRNAs, snoRNAs, target genes...
Arctigenin is a phenylpropanoid dibenzylbutyrolactone lignan compound possessing antitumor, anti-inflammatory, anti-influenza, antioxidant, antibacterial, and hypoglycaemic activities. Our previous study demonstrated that arctigenin exerts neuroprotective effects both <i>in vitro</i> vivo</i> in Parkinson's disease model. However, the exact mechanism through which improves amyloid beta-induced memory impairment by inhibiting production of hyperphosphorylated tau protein unknown. Amyloid...
As a result of low bioavailability, the majority Cyclocarya paliurus flavonoids (CPF) remain in large intestine where they accumulate to exert modulatory effect on intestinal micro-ecology. Therefore, present study investigated CPF microbiota.CPF dramatically ameliorated obesity-induced gut dysbiosis. A significant decrease (P < 0.05) was observed ratio Firmicutes/Bacteroidetes after treatment for 8 weeks. Moreover, Kyoto Encyclopedia Genes and Genomes pathways biosynthesis amino acids,...
Abstract Circular RNA (circRNA) has been reported to have great scientific significance and clinical value in multiple cancers including colorectal cancer (CRC). However, the biological function of most circRNAs CRC is still its infancy. Herein, we discovered differential expressed (DECs) between tissues matched adjacent using deep sequencing further confirmed DECs expression by combining with another Gene Expression Omnibus dataset. Furthermore, validated top four upregulated...
Increasing evidence supports long non-coding RNA-ZFAS1 as master protein regulators involved in a variety of human cancers. However, the molecular mechanism is not fully understood colorectal cancer (CRC) and remains to be elucidated. Here, we uncovered previously unreported linking RNA helicase DDX21 regulated by lncRNA ZFAS1 control POLR1B expression CRC initiation progression. Specifically, exerted its oncogenic functions was significantly up-regulated accompanied elevated DDX21, cells...
To investigate the relationship between dynamic changes in neutrophil-to-lymphocyte ratio (NLR) and neurological recovery noninfected patients with acute cerebral infarction after thrombolysis. A retrospective analysis was conducted on 277 stroke Least absolute shrinkage selection operator (LASSO) regression used to identify factors influencing recovery, 1:1 propensity matching performed groups compare National Institutes of Health Stroke Scale (NIHSS) score, muscle strength, NLR treatment....
Psoralen, the simplest linear furanocoumarin, is derived from many medicinal plants, such as Psoralea corylifolia L., Glehnia littoralis Fr. Schmidt ex Miq., and Peucedanum decursivum (Miq.) Maxim. It has been used for treating osteoporosis some skin disorders, including vitiligo, psoriasis, atopic eczema. This review focuses on pharmaceutical design of psoralen structure-activity relationships (SARs) its derivatives. also includes biosynthetic pathways, metabolic characteristics,...
Ethnopharmacological relevance Gastrodin is the main bioactive metabolite of Gastrodia elata Blume traditional Chinese medicine, which has pharmacological effects such as anti-inflammatory, antioxidant, neuroprotective, vasoprotective, hypoglycemic, lipotropic, analgesic, anticancer, antiviral and so on, it been widely used in treatment a wide range diseases, especially neurological disorders. Aim review Cerebral ischemia-reperfusion injury (CIRI) defined transient or permanent ischemia...
Hepatitis B virus (HBV) encoded X protein (HBx) has been implicated in apoptotic and related pathogenic events during hepatocellular carcinoma. However, the underlying molecular mechanism through which HBx acts is largely unclear. We used tandem affinity purification under mild conditions to gain insight into interactome HBV-producing HepG2.2.15 cells identified 49 proteins by mass spectrometry that are potentially associated with HBx. Two of key caspase-independent apoptosis pathway were...
Genome-wide association studies (GWAS) have reported a number of loci harboring common variants that influence risk colorectal cancer (CRC) in European descent. But all the SNPs identified explained small fraction total heritability. To identify more genetic factors modify CRC, especially Chinese Han specific, we conducted three-stage GWAS including screening stage (932 CRC cases and 966 controls) two independent validations (Stage 2: 1,759 1,875 controls; Stage 3: 943 1,838 controls). In...
Abstract The pTEN/AKT/mTOR signaling pathways play a critical role in balancing cell proliferation, differentiation, and survival. Recent studies researched the associations of core genes pathway polymorphisms with cancer susceptibility; however, results are inconclusive. Therefore, systematically meta-analysis was performed to evaluate association between five SNPs ( mTOR rs2295080 rs2536, AKT1 rs2494750 rs2494752, pTEN rs701848) risk by systematic review literature 31 eligible studies....
Worldwide, lower respiratory tract infections (LRTI) are an important cause of hospitalization in children. Due to the relative limitations traditional pathogen detection methods, new methods needed. The purpose this study was evaluate value metagenomic next-generation sequencing (mNGS) bronchoalveolar lavage fluid (BALF) samples for diagnosing children with LRTI based on interpretation results. A total 211 admitted First Affiliated Hospital Guangzhou Medical University from May 2019...
Type 2 diabetes (T2DM) is a complex multifactorial metabolic disorder that affects >100 million individuals worldwide, yet the mechanisms involved in development and progression of disease have not been fully elucidated. The present study examined mRNA micro (mi)RNA expression profiles by microarray analysis pancreas islets spontaneously diabetic Goto-Kakizaki rats with aim to identify regulatory underlying pathogenesis T2DM. A total 9 upregulated 10 downregulated miRNAs were identified,...
Abnormal DNA methylation is a major early contributor to colon cancer (COAD) development. We conducted cohort-based systematic investigation of genome-wide using 299 COAD and 38 normal tissue samples from TCGA. Through conditional screening machine learning with training cohort, we identified one hypomethylated nine hypermethylated differentially methylated CpG sites as potential diagnostic biomarkers, used them construct COAD-specific model. Unlike previous models, our model precisely...
Multiple factors are involved in oxaliplatin-resistant process colorectal cancer (CRC) patients including decreased drug accumulation and enhanced capacity to repair tolerate DNA damage. In the present study, we aimed assess impact of six single-nucleotide polymorphisms (SNPs) genes ABCG2 gene on prognosis advanced CRC treated with oxaliplatin-based chemotherapy.In this 580 were recruited. Six SNPs (XPA rs10817938, XPA rs2808668, XPC rs2607775, WRN rs1346044) (rs2231142 rs2622621) genotyped...
The long non-coding RNA H19 plays critical roles in cancer occurrence, development, and progression. present study is for the first time to evaluate association of genetic variations promoter region with advanced colorectal (CRC) susceptibility, environmental factors, clinical outcomes. 16 single-nucleotide polymorphisms (SNPs) were identified gene by DNA sequencing, 3 SNPs among which including rs4930101, rs11042170, rs2735970 further expanded samples 572 CRC patients 555 healthy controls....
There is a significant relationship between intestinal polyps and colorectal cancer, in recent years, research on has been rapidly developing around the world. However, there still lack of adequate quantification analysis publications this field. The aim study was to perform comprehensive bibliometric related over past 20 years. To enhance understanding current hotspots potential trends, point out direction future research. Publications were retrieved from Science Citation Index Expanded Web...