A5101990440- Gastric Cancer Management and Outcomes
- Colorectal and Anal Carcinomas
- Colorectal Cancer Surgical Treatments
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Peripheral Neuropathies and Disorders
- Hereditary Neurological Disorders
- Metastasis and carcinoma case studies
- Esophageal Cancer Research and Treatment
- Gastrointestinal Tumor Research and Treatment
- Cancer Immunotherapy and Biomarkers
- Medicinal Plant Pharmacodynamics Research
- Medical Imaging Techniques and Applications
- Colorectal Cancer Treatments and Studies
- Esophageal and GI Pathology
- Cancer, Hypoxia, and Metabolism
- Neuroendocrine Tumor Research Advances
- Lung Cancer Diagnosis and Treatment
- MRI in cancer diagnosis
- Neurology and Historical Studies
- Chemotherapy-induced organ toxicity mitigation
- Peripheral Nerve Disorders
- Nanoplatforms for cancer theranostics
- Single-cell and spatial transcriptomics
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2024
Air Force Medical University
2024
Xijing Hospital
2024
Huazhong University of Science and Technology
2022
Wuhan Children's Hospital
2022
First Affiliated Hospital of Anhui Medical University
2021
Anhui Medical University
2021
China Medical University
2021
Qinghai University Affiliated Hospital
2004-2018
Jinling Institute of Technology
2016
With poor prognosis and limited treatment options for advanced hepatocellular carcinoma (HCC), development of novel therapeutic agents is urgently needed. This single-arm phase I study sought to assess the safety preliminary efficacy icaritin in human as a potential oral immunotherapy addition immune-checkpoint inhibitors. Eligible HCC patients with Child-Pugh Class A or B were administered fixed dose at either 600 800 mg b.i.d. The primary endpoint was safety, secondary endpoints included...
Purpose: No validated biomarkers that could identify the subset of patients with lung adenocarcinoma who might benefit from chemotherapy have yet been well established. This study aimed to explore potential biomarker model predictive efficacy and survival outcomes after first-line pemetrexed plus platinum doublet based on metabolomics profiling.Experimental Design: In total, 354 consecutive eligible were assigned receive in combination either cisplatin or carboplatin. Prospectively collected...
Abstract Advanced hepatitis B virus (HBV)‐related hepatocellular carcinoma HCC with poor prognosis is often associated chronic inflammation, immune tolerance, and marked heterogeneity. The interleukin‐6 (IL‐6)/JAK/STAT3 signal pathways play multiple regulatory roles in modulating inflammation immunity cancers. Polarization of myeloid‐derived suppressor cells (MDSCs) involved HBV‐related immunosuppression CD8 + T‐cell activation through ERK/IL‐6/STAT3. Icaritin a small molecule that has...
This study aims to investigate the feasibility, safety and efficacy of triplet regimen neoadjuvant chemotherapy in patients with locally advanced resectable colon cancer. Patients clinical stage IIIb cancer received a perioperative triple (oxaliplatin 85 mg/m2 irinotecan 150 mg/m2, combined folinic acid 200 mg, 5-fluorouracil 500 mg bolus then 2,400 by 44 h infusion or capecitabine 1 g/m2 S-1 40-60 b.i.d orally d 1-10, repeated at 2-week intervals) for 4 cycles. Complete mesocolic excision...
To construct and validate a prediction model based on dual-layer detector spectral CT (DLCT) clinico-radiologic features to predict the microsatellite instability (MSI) status of gastric cancer (GC) explore relationship between results patient prognosis.
Anastomotic leak is an important cause of morbidity and mortality after esophagectomy for esophageal cancer patients. Calcification the arteries supplying gastric tube has been found to be associated with leakage cervical anastomosis in Europeans. The purpose this study evaluate association between calcifications occurrence anastomotic Chinese patients cancer.The demographic, clinical, pathological features as well vascular calcification 709 who had undergone esophagectomies were analyzed....
Background: Extramural venous invasion (EMVI) has been found to be related poor prognosis in gastric cancer. Preoperative diagnosis of EMVI is challenging, as it can only detected by surgical pathology. The present study aimed investigate the value quantitative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and diffusion-weighted (DWI) predicting preoperatively, determine relationship between prediction results patients with locally advanced cancer (LAGC). Methods: Between...
Gene therapy using recombinant adeno-associated virus (rAAV) relies on safe, efficient, and precise in vivo gene delivery that is largely dependent the AAV capsid. The proteinaceous capsid highly amenable to engineering a variety of approaches, most resulting capsids carry substitutions or insertions comprised natural amino acids. Here, we incorporated non-canonical acid (ncAA), Nε-2-azideoethyloxycarbonyl-L-lysine (also known as NAEK), into AAV5 genetic code expansion, serendipitously found...
Abstract Background Because of rapid disease progression and lack optimal treatment strategies beyond the second-line, prognosis patients with extensive-stage (ES) small cell lung cancer (SCLC) still remains depressing. Alternative are required to improve their prognosis. In this prospective clinical study, we aimed evaluate feasibility single-agent apatinib, a vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor, as option for ES-SCLC after failure at least two prior...
Abstract Purpose Chemoradiotherapy (CRT) remains the standard treatment for locally advanced rectal cancer (LARC). This phase 2 clinical trial was designed to evaluate efficacy and safety of neoadjuvant triplet chemotherapy with mFOLFOXIRI (folinic acid, 5-fluorouracil, oxaliplatin, irinotecan) in LARC. Patients methods The patients LARC (the lower edge more than 5 cm from anal verge) received up cycles mFOLFOXIRI. MRI performed assess baseline postchemotherapy TN stage. Radical resection...
Abstract Novel neoadjuvant immunotherapy combined with chemotherapy (neoICT) has improved outcomes for patients esophageal squamous-cell carcinoma (ESCC), but challenges persist in low response rates and therapy resistance. Little is known about the intra-tumoral heterogeneity ESCC tumor microenvironment (TME) that underlies differential responses to therapy. We applied single-cell RNA sequencing (scRNA-seq) profiling multiplexed immunofluorescence staining thoroughly decipher TME specimens...
This study aimed to explore the predictive value of quantitative dynamic contrast-enhanced MRI (DCE-MRI) and intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) parameters for response neoadjuvant chemotherapy (NCT) in locally advanced gastric cancer (LAGC) patients, relationship between prediction results patients' prognosis, so as provide a basis clinical individualized precision treatment.One hundred twenty-nine newly diagnosed LAGC patients who underwent IVIM-DWI DCE-MRI...
Abstract Background Peri-operative chemo-radiotherapyplayed important rolein locally advanced gastric cancer. Whether preoperative strategy can improve the long-term prognosis compared with postoperative treatment is unclear. The study purpose to compare oncologic outcomes in cancer patients treated chemo-radiotherapy (pre-CRT) and (post-CRT). Methods From January 2009 April 2019, 222 from 2 centers stage T3/4 and/or N positive who received pre-CRT post-CRT were included. After propensity...
Objective We evaluated and compared the efficacy safety of neoadjuvant chemoradiotherapy (NACRT) versus chemotherapy (NACT) for locally advanced gastric cancer (LAGC) in a single-center randomized phase II trial. Methods Patients with LAGC were enrolled received either NACT or NACRT, followed by gastrectomy adjuvant chemotherapy. The primary endpoint was an R0 resection rate. Results 75 patients: 75.7% (NACT, 28/37 patients) 76.3% (NACRT, 29/38 underwent surgery; rates 73.0% (27/37) 73.7%...
The study aims to investigate the correlation of CT characteristics with pathological classifications and prognostic value features in patients gastric neuroendocrine neoplasms (g-NENs).Ninety-one cases pathologically diagnosed g-NENs, including 15 well-differentiated tumors (NETs) (G1 G2) 76 poor-differentiated carcinomas (NECs) (G3 MANEC) were retrospectively studied. All included analysis pathologic grades. Among them, who had fulfilled follow-up data for overall survival (OS)...
Abstract Non‐small‐cell lung cancer (NSCLC) accounts for approximately 80% of cases. TBC1D23, a member the TBC/RABGAP family, is widely expressed in human tissues; however, its role NSCLC currently unknown. Immunohistochemical analysis was conducted on 173 paraffin‐embedded tissue sections from patients with 2014 to 2018 at First Affiliated Hospital China Medical University. MTT, colony formation assay, cell cycle scratch transwell Western blotting and real‐time PCR were employed multiple...
Previous studies have reported that neoadjuvant chemoradiotherapy can downstage the advanced gastric cancer. However, no are available on application of hypo-radiotherapy to radiotherapy. This study sought assess maximum tolerated dose (MTD) and dose-limited toxicity (DLT) hypo-fractionated for local cancer.Patients with cT3-4 and/or lymph node-positive locally cancer or Siewert II/III esophagogastric junction adenocarcinoma were enrolled. Preoperative chemoradiation was followed by 3 cycles...
The lower neck and upper mediastinum are the major regions for postoperative radiotherapy (PORT) in thoracic esophageal squamous cell carcinoma (TESCC). However, there is no uniform standard regarding delineation of nodal clinical target volume (CTVnd). This study aimed to map recurrent lymph nodes cervical mediastinal explore a reasonable CTVnd PORT TESCC.We retrospectively reviewed patients our hospital with first and/or node recurrence (LNR) after upfront esophagectomy. All these were...
The purpose of this study is to explore the efficacy clinical and MRI-specific features for tumor grading brain invasion assessment in patient with meningioma. Our results showed that tumor-brain interface considered as a key factor, preoperative MRI has excellent performance diagnosing meningioma WHO grade invasion.
In post-hoc analyses of phaseIII randomized controlled study(STELLAR), to analyzethe prognostic impact oflateral pelvic lymph node (LPLN)metastasis in locally advanced rectal cancer (LARC).