A5025541711- Dialysis and Renal Disease Management
- Central Venous Catheters and Hemodialysis
- Photosynthetic Processes and Mechanisms
- Airway Management and Intubation Techniques
- Tracheal and airway disorders
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Acute Kidney Injury Research
- Plant Molecular Biology Research
- Oxidative Organic Chemistry Reactions
- Head and Neck Surgical Oncology
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Viral Infections and Vectors
- Plant Reproductive Biology
- interferon and immune responses
- Iron Metabolism and Disorders
- Metal-Catalyzed Oxygenation Mechanisms
- Advanced MRI Techniques and Applications
- Cancer-related molecular mechanisms research
- CRISPR and Genetic Engineering
- Proteoglycans and glycosaminoglycans research
- Sleep and related disorders
- Family and Patient Care in Intensive Care Units
- Porphyrin and Phthalocyanine Chemistry
Jiangsu University
2021-2025
Southern Medical University
2023-2025
Shanghai University of Traditional Chinese Medicine
2025
Community Health Center
2024
Renji Hospital
2014-2024
Shanghai Jiao Tong University
2014-2024
Guangdong Medical College
2024
Chongqing Medical University
2024
Children's Hospital of Chongqing Medical University
2024
Inner Mongolia Agricultural University
2024
Philipp Simon, Massimo Iorizzo, Allen Van Deynze and colleagues report the high-quality assembly of carrot genome, providing an important resource for crop improvement. They find a candidate gene that regulates carotenoid accumulation gain further insights into asterid genome evolution, including characterization two new polyploidization events. We chromosome-scale analysis (Daucus carota) first sequenced to include comparative evolutionary among members euasterid II clade. characterized...
Summary The pentatricopeptide repeat ( PPR ) proteins form one of the largest protein families in land plants. They are characterised by tandem 30–40 amino acid motifs that an extended binding surface capable sequence‐specific recognition RNA strands. Almost all them post‐translationally targeted to plastids and mitochondria, where they play important roles post‐transcriptional processes including splicing, editing initiation translation. A code describing how recognise their targets...
Cultivated soybean [Glycine max (L.) Merr.] is a primary source of vegetable oil and protein. We report landscape analysis genome-wide genetic variation an association study major domestication agronomic traits in soybean. A total 106 genomes representing wild, landraces, elite lines were re-sequenced at average 17x depth with 97.5% coverage. Over 10 million high-quality SNPs discovered, 35.34% these have not been previously reported. Additionally, 159 putative sweeps identified, which...
Reproductive isolation is a prerequisite for speciation. Failure of communication between female tissues the pistil and paternal pollen tubes imposes hybridization barriers in flowering plants. Arabidopsis thaliana LURE1 (AtLURE1) peptides their male receptor PRK6 aid attraction growing tube to ovule. Here, we report that knockout entire AtLURE1 gene family did not affect fertility, indicating AtLURE1-PRK6-mediated signaling required successful fertilization within one species. AtLURE1s...
Solar ultraviolet radiation (UV) may cause DNA damage. We first report in this study that the large subunit ribosome protein RPL12, from Bomby mori (BmRPL12), participated UV-induced damage repair. BmRPL12 enhanced resistance of Escherichia coli (E. coli) to UV and facilitated faster repair silkworm cells. mainly existed cytoplasm dimer forms, N-terminal nuclear export signal was crucial for localization BmRPL12. After radiation, unable localize at sites participate directly might indirectly...
The transcription factors CBF1/2/3 are reported to play a dominant role in the cold responsive network of Arabidopsis by directly regulating expression levels (COR) genes. In this study, we obtained CRISPR/Cas9-mediated loss-of-function mutants cbf1∼3. Over 3,000 COR genes identified RNA-seq analysis showed slight but significant change their compared wild-type plants after being treated at 4 °C for 12 h. C-repeat (CRT) motif (5'-CCGAC-3') was enriched promoters that were up-regulated CBF2...
Background Several studies have suggested that urgent-start peritoneal dialysis (PD) is a feasible alternative to hemodialysis (HD) in patients with end-stage renal disease (ESRD), but the impact of modality on outcome, especially short-term complications, has not been directly evaluated. The aim current study was compare complications and outcomes PD HD ESRD patients. Methods In this retrospective study, who initiated urgently without pre-established functional vascular access or catheter...
Abstract Lymph node metastasis (LNM), a common metastatic gastric-cancer (GC) route, is closely related to poor prognosis in GC patients. Bone marrow-derived mesenchymal stem cells (BM-MSCs) preferentially engraft at lesions. Whether BM-MSCs are specifically reprogrammed by LNM-derived (LNM-GCs) and incorporated into LN microenvironment prompt malignant progression remains unknown. Herein, we found that LNM-GCs educated via secretory exosomes. Exosomal Wnt5a was identified as key protein...
The endoplasmic reticulum (ER)–localized stimulator of interferon genes (STING) is the core adaptor for pathogenic-DNA–triggered innate response. Aberrant activation STING causes autoinflammatory and autoimmune diseases, raising concern about how finely tuned during response to pathogenic DNAs. Here, we report that transmembrane domain (TM)–containing ER-localized E3 ubiquitin ligase TRIM13 (tripartite motif containing 13) required restraining inflammatory deficiency enhances cytokine...
Background Lymph node metastasis (LNM) commonly occurs in gastric cancer (GC) and is tightly associated with poor prognosis. Exosome-mediated lymphangiogenesis has been considered an important driver of LNM. Whether exosomes directly transmit the LNM phenotype between GC cells its mechanisms remain elusive. Methods A highly lymphatic metastatic cell line (HGC-27-L) was established by serial passage parental HGC-27 BALB/c nude mice. The capacities migration, invasion LNM; fatty acid oxidation...
The mechanism by which respiratory syncytial virus (RSV) suppresses T-cell proliferation to itself and other antigens is poorly understood. We used monocyte-derived dendritic cells (MDDC) CD4 T measured [(3)H]thymidine incorporation determine the factors responsible for RSV-induced suppression. These two cell types were sufficient suppression of in response cytomegalovirus or Staphylococcus enterotoxin B. Suppressive activity was transferable with supernatants from RSV-infected MDDC not due...
Abstract. Objective : Two types of interferons (IFNs), type I (IFN‐α/β) and III (IFN‐λs), utilize distinct receptor complexes to induce similar signalling biological activities, including recently demonstrated for IFN‐λs antitumour activity. However, ability IFNs regulate cell population growth remains largely uncharacterized. Materials methods Intact modified human colorectal adenocarcinoma HT29 cells were used study regulation apoptosis by IFN‐λs. Results Conclusions We report that the...
Type I (IFN-alpha/beta) and type III (IFN-lambdas) IFNs are important components of the host antiviral response. Although possess intrinsic activity similar to that IFNs, they signal through a specific unique receptor complex, their functional importance for resistance is largely uncharacterized. Here, we report first virus defense mechanism directly targets IFNs. Y136 from Yaba-like disease virus, yatapoxvirus, secreted glycoprotein related protein B18 Vaccinia known IFN-binding member Ig...
SUMMARY Background Most elderly people undergoing peritoneal dialysis (PD) treatment have a high incidence of frailty, cognitive impairment and emotional disturbance leading to significant impact on families. The burden experienced by the family caregivers could affect their physical emotion health. objective this study was examine level adults receiving PD identify any contributing factors. Materials Methods This cross‐sectional employing convenience sampling. Patient–caregiver dyads were...
An efficient enantioselective synthesis of cyclic α-aminophosphonates via multicomponent reactions 2-alkynylbenzaldehydes, amines, and dimethylphosphonate has been developed with the use a chiral silver spirocyclic phosphate as catalyst. This protocol provides straightforward access to series C1-phosphonylated 1,2-dihydroisoquinoline derivatives high yields (up 99%) enantioselectivities 94% ee) for broad substrate scope. The products could be further transformed into densely functionalized...
Sensing of pathogenic nucleic acids by pattern recognition receptors (PRR) not only initiates anti-microbe defense but causes inflammatory and autoimmune diseases. E3 ubiquitin ligase(s) critical in innate response need to be further identified. Here we report that the tripartite motif-containing ligase TRIM41 is required antiviral through facilitating acids-triggered signaling pathway. deficiency impairs production cytokines type I interferons macrophages after transfection with acid-mimics...
Developing highly efficient catalytic protocols for C-sp(3)-H bond aerobic oxidation under mild conditions is a long-desired goal of chemists. Inspired by nature, biomimetic approach the galactose oxidase model compound CuIIL and NHPI (N-hydroxyphthalimide) was developed. The CuIIL-NHPI system exhibited excellent performance in bonds to ketones, especially light alkanes. protocol had broad substrate scope. Mechanistic studies revealed that CuI-radical intermediate species generated from...