A5100427983- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Plant Molecular Biology Research
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA Interference and Gene Delivery
- Ferroptosis and cancer prognosis
- Angiogenesis and VEGF in Cancer
- Viral Infections and Vectors
- Lung Cancer Treatments and Mutations
- Cell Adhesion Molecules Research
- Immune Cell Function and Interaction
- Kruppel-like factors research
- Cancer, Hypoxia, and Metabolism
- Coronary Interventions and Diagnostics
- Genital Health and Disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Air Quality and Health Impacts
- Nanopore and Nanochannel Transport Studies
- Supply Chain and Inventory Management
- Wnt/β-catenin signaling in development and cancer
- Renal cell carcinoma treatment
- Systemic Sclerosis and Related Diseases
Shanghai University of Traditional Chinese Medicine
2023-2025
First Affiliated Hospital of Fujian Medical University
2025
Fujian Medical University
2023-2025
Shandong Eye Hospital
2024
Shandong First Medical University
2024
Second Hospital of Hebei Medical University
2024
Yuhuangding Hospital
2024
Hebei Medical University
2024
Huazhong University of Science and Technology
2021-2024
Tongji Hospital
2024
A hypoxic microenvironment is a common feature of skin wounds. Our previous study demonstrated that three-dimensional coculture umbilical cord-derived mesenchymal stem cells (ucMSCs) and endothelial facilitates cell communication host integration in tissue engineering. Here, we aimed to identify the mechanism by which ucMSCs affect under conditions after injury. We demonstrate hypoxia enhances exosome-mediated paracrine function ucMSCs, increases proliferation migration. In mouse...
Abstract Background Blood biomarkers that can be used for preclinical Alzheimer’s disease (AD) diagnosis would enable trial enrollment at a time when the is potentially reversible. Here, we investigated plasma neuronal-derived extracellular vesicle (nEV) cargo in patients along continuum, focusing on cognitively normal controls (NCs) with high brain β-amyloid (Aβ) loads (Aβ+). Methods The study was based Sino Longitudinal Study Cognitive Decline project. We enrolled 246 participants,...
Background Lymph node metastasis (LNM) commonly occurs in gastric cancer (GC) and is tightly associated with poor prognosis. Exosome-mediated lymphangiogenesis has been considered an important driver of LNM. Whether exosomes directly transmit the LNM phenotype between GC cells its mechanisms remain elusive. Methods A highly lymphatic metastatic cell line (HGC-27-L) was established by serial passage parental HGC-27 BALB/c nude mice. The capacities migration, invasion LNM; fatty acid oxidation...
Autophagy plays an important role in PPRV pathogenesis. The of exosomes viral infections is beginning to be appreciated.
Enhancer of zeste homolog 2 (EZH2) is the lysine methyltransferase polycomb repressive complex (PRC2) that catalyzes H3K27 tri-methylation. Aberrant expression and loss-of-function mutations EZH2 have been demonstrated to be tightly associated with pathogenesis various myeloid malignancies characterized by ineffective erythropoiesis, such as myelodysplastic syndrome (MDS). However, function mechanism in human erythropoiesis still remains largely unknown. Here, we regulates a stage-specific,...
Uveal melanoma (UM) is a common intraocular malignancy in adults frequently with metastasis and poor survival. This study aimed to identify genes, pathways the ceRNA axes related of UM. The GSE73652 dataset was downloaded 1719 differentially expressed RNAs (DE-RNAs), including 13 lncRNAs, 5 miRNAs, 1701 were identified metastatic UM samples compared non-metastatic ones. A total 11 lncRNA-miRNA pairs by interviewing DIANA-LncBase database. In addition, 49 UM-related KEGG filtered CTD search...
Hepatocellular carcinoma (HCC), a prevalent and highly malignant form of liver cancer, poses significant global health challenges. Previous studies have suggested that alterations in cleavage polyadenylation specificity factors (CPSFs) play role the development prognosis HCC. Despite these insights, thorough evaluation CPSFs' expression levels, prognostic value association with immune infiltration HCC is lacking. To address this gap, present study conducted systematic analysis leveraging...
This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). retracted at the request of editor-in-chief. The editor-in-chief was informed evidence for image duplication in identical or altered fashion Figures 3A and 8D, as well undisclosed reuse an Figure 5B from a previous Cell Death & Disease (https://doi.org/10.1038/s41419-018-0902-5), PubPeer thread: https://pubpeer.com/publications/F5B591481C516F4CE42C7925AC48E9....
Diffuse large B-cell lymphoma (DLBCL) is one type of highly heterogeneous lymphoid malignancy with 30%~40% patients experiencing treatment failure. Novel risk stratification and therapeutic approaches for DLBCL are urgently needed. Endothelial-to-mesenchymal transition (EndMT), which contributes to tumor angiogenesis, metastasis, drug resistance, cancer-associated fibroblast generation, has been detected in the microenvironment many types cancers. However, existence EndMT hematological...
Peste des petits ruminants virus (PPRV) is an important pathogen that seriously influences the productivity of small worldwide. PPRV lymphotropic in nature and SLAM was identified as primary receptor for other Morbilliviruses . Many viruses have been demonstrated to engage extracellular vesicles (EVs) facilitate their replication pathogenesis. Here, we provide evidence infection significantly induced secretion levels EVs from goat PBMC, PPRV-H protein carried can enhance expression recipient...
The density and composition of lymphocytes infiltrating colon tumors serve as predictive factors for the clinical outcome cancer. Our previous studies highlighted potent anti-cancer properties principal compounds found in
We describe the discovery of three structurally differentiated potent and selective MTH1 inhibitors their subsequent use to investigate as an oncology target, culminating in target (in)validation. Tetrahydronaphthyridine 5 was rapidly identified a highly inhibitor (IC50 = 0.043 nM). Cocrystallization with revealed ligand Φ-cis-N-(pyridin-2-yl)acetamide conformation enabling key intramolecular hydrogen bond polar interactions residues Gly34 Asp120. Modification literature compound TH287 O-...
Abstract Purpose Interstitial lung diseases (ILDs) have high morbidity and mortality poor prognosis. The significance of microRNAs (miRNAs) was highlighted in ILDs development. Currently, we attempted to confirm the functions cancer-derived exosomal miR-132-3p reveal underlying mechanism. Method Characteristics exosomes were verified by transmission electron microscope (TEM), nanoparticle tracking analysis, Western blot assay. Exosome uptake for normal human fibroblasts (NHLF) assessed using...
Abstract Background G-protein-coupled receptors(GPRs) are the largest family of membrane proteins in human genome, positively involving physiological and metabolic activities. Drugs targeted to GPRs have developed fast. However, there still few GPR-targeted drugs for cancer treatment. GPR183, an orphan seven-transmembrane receptor, been widely studied immune regulation. Yet, its role tumor immunity remains mysterious. Results In our study, we performed a pan-cancer analysis GPR183 . Though...