A5103103127- Protease and Inhibitor Mechanisms
- MicroRNA in disease regulation
- Pharmacological Effects of Natural Compounds
- RNA modifications and cancer
- Adenosine and Purinergic Signaling
- Cancer-related Molecular Pathways
- Botanical Research and Chemistry
- Peptidase Inhibition and Analysis
- Liver Diseases and Immunity
- Cytokine Signaling Pathways and Interactions
- Natural product bioactivities and synthesis
- Receptor Mechanisms and Signaling
- Histone Deacetylase Inhibitors Research
- Prostate Cancer Treatment and Research
- Pediatric Hepatobiliary Diseases and Treatments
- Drug-Induced Hepatotoxicity and Protection
- Hormonal Regulation and Hypertension
- Birth, Development, and Health
- Biomarkers in Disease Mechanisms
- Pulmonary Hypertension Research and Treatments
- Reproductive Biology and Fertility
- Colorectal Cancer Treatments and Studies
- Liver Disease Diagnosis and Treatment
- Traditional Chinese Medicine Analysis
- Plant Toxicity and Pharmacological Properties
Ningxia Medical University
2023-2024
University of Electronic Science and Technology of China
2018-2023
Shanghai Children's Hospital
2023
Shanghai Jiao Tong University
2020-2023
China Pharmaceutical University
2021
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2018
National Taiwan University
2016
Yigong San (YGS) is a representative prescription for the treatment of digestive disorders, which has been used in clinic more than 1000 years. However, mechanism its anti-gastric cancer and regulate immunity are still remains unclear.
Background: Cholestasis is a common pathological process in variety of liver diseases that may lead to fibrosis, cirrhosis, and even failure. relief has been regarded as principal target the management multiple chronic cholestasis like primary sclerosing cholangitis (PSC) biliary (PBC) at present. However, complicated pathogenesis limited acknowledgments fettered therapeutic development. Therefore, this study aimed systematically analyze miRNA-mRNA regulatory networks cholestatic injury...
Background: Inhibition of fatty acid synthase (FAS) plays a crucial protective role in pulmonary hypertension (PH). Our aim was to identify novel metabolites mice with hypoxia-induced PH after treatment C75 (FAS inhibitor) and confirm the presence these paediatric patients PH. Methods: The mouse model built by chronic hypoxia ovalbumin (OVA) assistance. Untargeted metabolomics used analyse serum. Six children six relative controls (patients without lung heart disease) were selected Shanghai...
Background: BIRC7, which encodes Baculoviral inhibitor of apoptosis (IAP) repeat-containing protein 7, is an oncogene in multiple types cancer. In this study, we examined the association between BIRC7 expression and clinicopathological characteristics prostate cancer, independent prognostic value terms recurrence-free survival, molecular mechanisms its dysregulation. Methods: Data mining was performed using data from The Cancer Genome Atlas. patients were divided into high low groups...
Abstract Background G-protein-coupled receptors(GPRs) are the largest family of membrane proteins in human genome, positively involving physiological and metabolic activities. Drugs targeted to GPRs have developed fast. However, there still few GPR-targeted drugs for cancer treatment. GPR183, an orphan seven-transmembrane receptor, been widely studied immune regulation. Yet, its role tumor immunity remains mysterious. Results In our study, we performed a pan-cancer analysis GPR183 . Though...
Abstract BackgroundLiver cancer is an extremely heterogeneous malignant disease among tumors identified to date. In recent years, a large number of studies have found that low-concentration hydrogen or hydrogen-rich water hydrogen-saturated physiological saline has protective effect on many diseases. Observing the intervention and speculate whether its regulated by GP73/TGF-β signaling pathway would provide basis for clinical treatment using in liver cancer.MethodThe(N-nitrosodiethylamine)...
for the separate outcomes.P<0.05 was determined to be significant by Student paired t-test.RESULTS: A total of 17 women conceived with 16.8% per cycle and 28.3% cumulative (up 5 cycles) CPR.Percent motility percent morphology improved significantly in both pregnant non-pregnant after sperm processing (Table 1).In logistic regression model, factors which contributed pregnancy outcome were initial final concentration, TMSC (all at p<0.05).Notably, neither nor change impacted status...