A5100398263- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Catalytic C–H Functionalization Methods
- Chemical Synthesis and Analysis
- Asymmetric Synthesis and Catalysis
- Advanced biosensing and bioanalysis techniques
- Sulfur-Based Synthesis Techniques
- RNA Interference and Gene Delivery
- Synthetic Organic Chemistry Methods
- Oxidative Organic Chemistry Reactions
- Polymer Nanocomposites and Properties
- Fluorine in Organic Chemistry
- Asymmetric Hydrogenation and Catalysis
- Radical Photochemical Reactions
- Polymer composites and self-healing
- Magnesium Alloys: Properties and Applications
- Geological and Geochemical Analysis
- Carbohydrate Chemistry and Synthesis
- Supramolecular Self-Assembly in Materials
- Synthesis and Catalytic Reactions
- Glycosylation and Glycoproteins Research
- Nanoplatforms for cancer theranostics
- Synthesis of heterocyclic compounds
- Natural product bioactivities and synthesis
- Synthesis and biological activity
State Key Laboratory of Chemical Engineering
2022-2025
Tianjin University
2022-2025
Hebei University
2025
Fujian Agriculture and Forestry University
2025
Shanghai Sunshine Rehabilitation Center
2025
Nanjing Forestry University
2025
Wenzhou Medical University
2024
Ruian People's Hospital
2024
University of Münster
2023-2024
China University of Geosciences (Beijing)
2022-2024
We report the synthesis of hierarchical structured nanocrystals through an interfacial self-assembly driven microemulsion (μ-emulsion) process. An optically active macrocyclic building block Sn (IV) meso-tetraphenylporphine dichloride (tin porphyrin) is used to initiate noncovalent confined within μ-emulsion droplets. In-situ studies dynamic light scattering, UV–vis spectroscopy, and electron microscopy, as well optical imaging reaction processes suggest evaporation-induced nucleation growth...
Fluorinated small molecules are prevalent across the functional small-molecule spectrum, but scarcity of naturally occurring sources creates an opportunity for creative endeavour in developing routes to access these important materials. Iodine(I)/iodine(III) catalysis has proven be particularly well-suited this task, enabling abundant alkene substrates readily intercepted by situ-generated λ3-iodanes and processed high-value (di)fluorinated products. These organocatalysis paradigms often...
The bio-based epoxidized natural rubber (ENR) is considered a promising platform to design and fabricate sustainable high-performance materials. epoxide sites in the ENR chains contribute designing green cross-linking strategy reduce release of toxic volatile organic compounds achieve recycling end-of-life rubbers. However, it still challenging catalyst-free effective obtain cross-linked with mechanically robust properties. Herein, series carboxylic acids different chain lengths degrees...
Soy protein isolate (SPI) can be used as a carrier for essential oils in active packaging with the purpose of inhibiting growth spoilage microorganisms on food and extending storage time. This study assessed effect adding thyme oil (TEO) physical properties, antioxidant activity, antibacterial properties films (TEOF) using SPI film-forming matrix. The results indicated that property composite film is improved after TEO. Scanning electron microscopy (SEM), infrared spectroscopy X-ray...
A major challenge in using nanocarriers for intracellular drug delivery is their restricted capacity to escape from endosomes into the cytosol. Here, we significantly enhance efficiency by accurately predicting and regulating transition pH (pH0) of peptides modulate endosomal capability. Moreover, inverting chirality peptide carriers, could further ability deliver nucleic acid drugs as well antitumor drugs. The resulting carriers exhibit versatility transfecting various cell types with a...
Incorporating d-amino acids into peptides can influence the intermolecular interactions of peptides, thus determining morphology and functionality self-assembled supramolecular structures. Based on this, we propose a modular chirality regulation strategy designed four chiral by adjusting different functional modules. The control coassembly nucleic virus-like vesicles with controlled diameters enzyme-responsiveness. Compared homochiral heterochiral inversion in their hydrophobic domain...
Lipid nanoparticles (LNPs) with highly efficient and specific extrahepatic targeting abilities are promising in gene delivery, the lipopeptides (LPs) excellent designability functionality expected to empower construction of functional LNPs. This study aims develop ionizable components that accurately match different lipid systems through modular design LPs. Based on this, a lipopeptide-based organ-specific (POST) LNP screening strategy is constructed, which lysine-histidine-based (KH-LPs)...
An efficient I<sub>2</sub>–DMSO reagent system-mediated multicomponent reaction strategy for the synthesis of C3-sulfenylated chromones from <italic>o</italic>-hydroxyaryl methyl ketones, rongalite, and dimethyl sulfoxide has been developed.
A hypoxic microenvironment is a common feature of skin wounds. Our previous study demonstrated that three-dimensional coculture umbilical cord-derived mesenchymal stem cells (ucMSCs) and endothelial facilitates cell communication host integration in tissue engineering. Here, we aimed to identify the mechanism by which ucMSCs affect under conditions after injury. We demonstrate hypoxia enhances exosome-mediated paracrine function ucMSCs, increases proliferation migration. In mouse...
Traumatic hemorrhagic shock (THS) is a major cause of mortality and morbidity worldwide in severely injured patients. Mesenchymal stem cells (MSCs) possess immunomodulatory properties tissue repair potential mainly through paracrine pathway mediated by MSC-derived extracellular vesicles (MSC-EVs). Interleukin 10 (IL-10) potent anti-inflammatory cytokine that plays crucial role during the inflammatory response, with broad range effects on innate adaptive immunity, preventing damage to host...
Abstract Cyclic β,β‐difluoro‐carbonyl compounds have a venerable history as drug discovery leads, but limitations in the synthesis arsenal continue to impede chemical space exploration. This challenge is particularly acute arena of fluorinated medium rings where installing difluoromethylene unit subtly alters ring conformation by expanding internal angle (∠C−CF 2 −C>∠C−CH −C): this provides handle modulate physicochemistry (e.g. p K ). To reconcile disparity, highly modular expansion has...
In this study, we construct a green and high-performance platform using Pickering emulsions for biphasic catalysis. The oil-in-water stabilized by the lignin/chitosan nanoparticles (Lig/Chi NPs) have great stability alkali resistance, showing pH-responsive reversible emulsification demulsification which can be recycled at least three times. emulsion also has fluorescence wide availability to different oil-to-water volume ratios, types of oil, storage times, temperatures, ion concentrations....
l,l-Type and l,d-type (E)-alkene dipeptide isosteres (EADIs) that have unnatural side chains at the α-position were synthesized by combination of stereoselective aziridinyl ring-opening reactions organozinc−copper-mediated anti-SN2' toward a single substrate γ,δ-cis-γ,δ-epimino (E)-α,β-enoate. The utility this methodology was demonstrated synthesis set diastereomeric EADIs l-Arg-l/d-3-(2-naphthyl)alanine (Nal) is contained in small CXCR4 antagonist FC131 [cyclo(-d-Tyr-Arg-Arg-Nal-Gly-)]....
A practicable quinoline synthesis from aniline and two amino acids was developed for generating a wide range of quinolines with high efficiency diversity. Thus, it facilitated the creations pharmaceutical derivatives, photochemical active compounds, challenging scaffolds. The concept using as heterocyclic precursors has been raised first time. Mechanistic studies revealed that I2 enabled decarboxylation, oxidative deamination, selective reconstruction new C-N C-C bonds processes.
A simple and versatile glycosylation method with both armed disarmed glycosyl ynenoates as donors is developed. Employing a gold(I) complex catalyst or without the assistance of TfOH, scope present protocol very wide. The utility ynenoate demonstrated in efficient synthesis oligosaccharides via latent-active strategy multiple orthogonal one-pot strategy. Finally, this approach enables formal tetrasaccharide hapten Streptococcus pneumoniae serotype 3 highly convergent 32mer polymannoside.
Abstract Background Microarray data have been widely utilized for cancer classification. The main characteristic of microarray is “large p and small n” in that contain a number subjects but large genes. It may affect the validity Thus, there pressing demand techniques able to select genes relevant Results This study proposed novel feature (gene) selection method, Iso-GA, Iso-GA hybrids manifold learning algorithm, Isomap, genetic algorithm (GA) account latent nonlinear structure gene...
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The one-pot total synthesis of evodiamine and its analogues is achieved using a three-component reaction. Through continuous biscyclization, various readily available substrates with good functional group tolerance were easily incorporated into biologically active quinazolinocarboline backbones. use triethoxymethane as cosolvent was crucial for this quick straightforward transformation.
In order to further explore the effect of pre-aging treatment on large-scale alloys, a extruded Mg-9.32Gd-4.02Y-2.16Zn-0.48Zr (wt.%) alloy with large extrusion ratio (ER = 19.5) and temperature 450 °C in (Φ308 mm × 800 mm) was investigated this paper. It exhibited good properties more pronounced anisotropy. The comprehensive performance 45° direction best. (ED) presented high strength, while transverse (TD) showed poor strength ductility contemporaneously. main results anisotropy were...