Homogeneous platinum catalysts for hydrosilylation are essential the chemical industry and society, through production of commodities such as functional silicones. However, high boiling points products low concentration homogeneous make implementation traditional separation methods difficult. Catalyst loss becomes a core sustainability techno-economic challenge. In addition, highly active platinum-based have remarkable susceptibility to deactivation upon reaction completion. Recently,...

A highly efficient I2/Cu(NO3)2·3H2O-mediated triple C(sp3)–H functionalization reaction for the synthesis of 2,4,5-trisubstituted furans from aryl methyl ketones and rongalite by employing as a C1 unit has been developed. This method allows rapid access to (2-acyl-4-methylthio-5-aryl) furans. Preliminary mechanistic studies indicate that in situ generated dimethyl(phenacyl)-sulfonium iodine HCHO were probably key intermediates this transformation.

A highly efficient rongalite-mediated three-component radical annulation reaction to furnish fully substituted pyrazoles from aryldiazonium salts and α,β-unsaturated aldehydes or ketones under metal- oxidant-free conditions at room temperature has been developed. In this transformation, served as the precursor of both aryl hydrazine units. Mechanistic investigations indicated that rongalite could act a initiator reducing reagent simultaneously in reaction.

A highly para-selective C–C bond coupling is presented between phenols C(sp2) and aryl methyl ketones C(sp3), which enables the direct construction of 4-hydroxybenzil derivatives. This practical method exhibits a broad substrate scope large-scale applicability represents general gateway to hydroxybenzil natural product family. Mechanistic investigations indicated that combination HI with DMSO realized oxidative carbonylation ketones, while boric acid acted as dual-functional relay reagent...

A practicable quinoline synthesis from aniline and two amino acids was developed for generating a wide range of quinolines with high efficiency diversity. Thus, it facilitated the creations pharmaceutical derivatives, photochemical active compounds, challenging scaffolds. The concept using as heterocyclic precursors has been raised first time. Mechanistic studies revealed that I2 enabled decarboxylation, oxidative deamination, selective reconstruction new C-N C-C bonds processes.

A novel synthesis strategy of <italic>N</italic>-aminosulfonamides has been reported which uses rongalite as a radical initiator, SO₂ surrogate and reducing reagent simultaneously.

Selective C-C single bond cleavage of simple compounds is a highly challenging and desired process. Herein, chlorine radical-induced deconstructive alkylation with alcohols alkenes catalyzed by iron salts was reported for the first time. Readily available various electron-deficient were tolerated. Late-stage large-scale reactions proceed smoothly. This catalyst system shows potential diversified functionalization bonds.

This paper described a decarboxylative deaminative dual-coupling reaction of amino acids with indoles to afford BIM scaffolds and its further application the one-pot total synthesis natural products. method featured stimulating example activating in one pot as multi-carbon building blocks for transformation into final targets which are equipped acid side chain backbones.

The one-pot total synthesis of evodiamine and its analogues is achieved using a three-component reaction. Through continuous biscyclization, various readily available substrates with good functional group tolerance were easily incorporated into biologically active quinazolinocarboline backbones. use triethoxymethane as cosolvent was crucial for this quick straightforward transformation.

A newly developed phosphine ligand with a C2-cyclohexyl group on the indole ring was successfully applied in chemoselective Sonogashira coupling reaction excellent chemoselectivity, affording an inversion of conventional chemoselectivity order C-Br > C-Cl C-OTf. This study also provided efficient approach to synthesis polycyclic aromatic hydrocarbons (PAHs) and natural product analogue trimethyl-selaginellin L by merging Suzuki-Miyaura reactions.

In this work, a practical copper-catalyzed multicomponent coupling reaction of primary aromatic amines, rongalite, and alkynes for the direct synthesis N-aryl propargylamines has been developed. This method could overcome substrate limitation in A3 reactions formaldehyde, alkynes. Mechanistic studies revealed that rongalite acts as not only active C1 unit but also accelerator to activate situ-generated N-arylmethanimines with is highly efficient features broad scope, well utility scale-up...

Four different NHC ligands have been coordinated to Pt(II) centres; for the first time cyclometallation of ligand was observed, but only when platinum centre had a DMSO and two methyl co-ligands. Cyclometallation resulted in exclusive formation five-membered rings, absence any double reactions with appropriate rules out possibility an oxidative addition type mechanism reaction.

A novel mechanoredox-enabled synthesis of aromatic and aliphatic isothiocyanates from primary amines carbon disulfide under ball milling conditions using a piezoelectric material (BaTiO3) as the redox catalyst has been developed. This method displays several features, such short reaction time, operational simplicity, room temperature air conditions, minimal solvent, broad substrate scope, recyclable cheap catalyst. Preliminary mechanistic studies revealed that highly polarized acted...

A palladium-catalyzed chemoselective decarboxylative coupling of alkynyl carboxylic acids with halogenated aryl triflates has been developed for the efficient synthesis OTf-arylalkyne scaffolds.

Abstract We herein describe the development of a dimerization procedure for amino acids to prepare 2,5‐disubstituted thiazoles and oxazoles in presence Na 2 S⋅9H O H O, respectively. These approaches enabled direct formation five‐membered ring systems bearing two different heteroatoms from acid units. Mechanically, decarboxylation, deamination, S/O insertion, cyclization gradient oxidation processes were involved oligomer formation. magnified image

Abstract One central research goal for modern organic chemistry in society is to develop sustainable synthetic methodologies. Visible-light-induced transformations that apply earth-abundant metals as catalysts are a good reply this concern. In short review, recent developments of photocatalysis applying iron group metal (Fe, Co, Ni) discussed. Reaction types, the catalyst details, and mechanisms introduced. 1 Introduction 2 Visible-Light-Induced Fe-Catalyzed Reactions 3 Co-Catalyzed 4...

An expeditious one-step synthesis of the imidazopyridoindole scaffold was achieved through C-H oxidation/two-fold cyclization reaction methyl ketone and tryptamine derivatives. Mild oxidizing conditions were employed to realize efficient oxidation C(sp3)-H bonds, while suppressing overoxidation intermediate ensuring cross-trapping two in situ generated acylimine intermediates.