About
Contact & Profiles
A5062654944
Research Areas
- Viral Infections and Vectors
- Inflammasome and immune disorders
- interferon and immune responses
Zhejiang University
2022
Second Military Medical University
2022
The endoplasmic reticulum (ER)–localized stimulator of interferon genes (STING) is the core adaptor for pathogenic-DNA–triggered innate response. Aberrant activation STING causes autoinflammatory and autoimmune diseases, raising concern about how finely tuned during response to pathogenic DNAs. Here, we report that transmembrane domain (TM)–containing ER-localized E3 ubiquitin ligase TRIM13 (tripartite motif containing 13) required restraining inflammatory deficiency enhances cytokine...
10.1126/sciadv.abh0496
article
EN
cc-by-nc
Science Advances
2022-01-26
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