A5043809160- Glioma Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Meningioma and schwannoma management
- RNA modifications and cancer
- Brain Metastases and Treatment
- Bone Tumor Diagnosis and Treatments
- Ferroptosis and cancer prognosis
- Lung Cancer Treatments and Mutations
- RNA regulation and disease
- Protein Tyrosine Phosphatases
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Neurofibromatosis and Schwannoma Cases
- Lung Cancer Research Studies
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Cancer Cells and Metastasis
- Oral and Maxillofacial Pathology
- Vascular Malformations Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Pituitary Gland Disorders and Treatments
- Radiomics and Machine Learning in Medical Imaging
- CNS Lymphoma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Neuroblastoma Research and Treatments
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2024
Second Hospital of Anhui Medical University
2016-2024
Anhui Medical University
2016-2024
National Clinical Research
2021-2023
Peking Union Medical College Hospital
2021
Weatherford College
2021
China-Japan Friendship Hospital
2019
Sichuan University
2017
West China Hospital of Sichuan University
2017
Tumor recurrence, the chief reason for poor prognosis of glioma, is largely attributed to glioma stem cells (GSCs) and epithelial-mesenchymal transition (EMT). However, mechanisms among them remain unknown. Here, we determined whether leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5), known as a cell marker colon cancer gastric cancer, can serve novel GSC involved in EMT therapeutic target glioma. Stemness properties were examined FACS-isolated LGR5+/LGR5− cells. Reported...
Abstract Background Although the availability of therapeutic options including temozolomide, radiotherapy and some target agents following neurosurgery, prognosis glioma patients remains poor. Thus, there is an urgent need to explore possible targets for clinical treatment this disease. Methods Tissue microarrays immunohistochemistry were used detect FKBP10, Hsp47, p-AKT (Ser473), p-CREB (Ser133) PCNA expression in tissues xenografts. CCK-8 tests, colony formation assays xenograft model...
Brain metastasis, with the highest incidence in patients lung cancer, significantly worsens prognosis and poses challenges to clinical management. To date, how brain metastasis evades immune elimination remains unknown.
Abstract Introduction The prognosis of patients with glioma is dismal. It has been reported that Serpin peptidase inhibitor clade A member 3 (SERPINA3) associated the mobility and invasion tumor cells. Our study was designed to explore value SERPINA3 messenger RNA (mRNA) expression in biological process, prognosis, immune significance glioma. Methods We analyzed functions through data from Chinese Glioma Genome Atlas databases. Differentially expressed genes enrichment analysis were...
Leptomeningeal metastasis (LM) commonly occurs in non-small cell lung cancer (NSCLC) patients and has a poor prognosis. Due to limited access leptomeningeal lesions, the genetic characteristics of LM have not been explored date. Cerebrospinal fluid (CSF) may be most representative liquid biopsy medium obtain genomic information from NSCLC.CSF biopsies matched peripheral blood were collected 33 NSCLC with LM. We profiled alterations by comparing CSF cell-free DNA (cfDNA) plasma cfDNA. Somatic...
Background Chronic subdural hematoma (CSDH) represents a prevalent medical condition, posing substantial challenges in postoperative management due to risks of recurrence. Such recurrences not only cause physical suffering the patient but also add financial burden on family and health care system. Currently, prognosis determination largely depends clinician expertise, revealing dearth precise prediction models clinical settings. Objective This study aims use machine learning (ML) techniques...
Hypothetically, intratumoral genomic heterogeneity has the potential to foster tumor-infiltrating lymphocyte (TIL) diversity; however, no study directly tested this hypothesis by simultaneously investigating somatic mutations, TIL diversity, and immune response activity. Thus, we performed whole-exome sequencing, repertoire sequencing gene expression on ten spatially separated tumor samples obtained from two masses excised a glioblastoma multiforme (GBM) patient, included peripheral blood as...
Glioma is the most common and aggressive type of human primary brain tumor with a poor outcome. The molecular mechanisms underlying glioma development progression are still poorly understood. Recent studies have reported novel role ARPP-19 in regulation cell mitosis cancer progression. However, no study has been carried out to determine cells assess expression clinical significance glioma. In this study, we systematically examined A172 CD147 81 cases tissue specimens correlated them...
The prognosis of patients with glioblastoma (GBM) is dismal. It has been reported that Insulin-like growth factor (IGF) binding protein 2 (IGFBP2) associated the mobility and invasion tumor cells. We investigated expression IGFBP2 mRNA in GBMs its clinical relevance, using tissue microarrays RNAscope situ hybridization 180 13 normal or edematous tissues. correlations between pathological parameters as well some other biomarkers were analyzed. Overexpression was observed 23.9% tumors tested....
Temozolomide (TMZ) is considered a standard chemotherapeutic agent for glioblastoma (GBM). Characterizing the biological molecules and signaling pathways involved in TMZ sensitivity would be helpful selecting therapeutic schemes evaluating prognosis GBM. Thus, present study, we selected 34 glioma cell lines paired with specific IC50 values of obtained from CancerRxGene RNA-seq data downloaded Cancer Cell Line Encyclopedia to identify genes related sensitivity. The results showed that 1,373...
Background: Diffuse gliomas are the most common malignant brain tumors, and immune checkpoint inhibitors have limited therapeutic effects against this cancer. Three oncogenic pathways altered in diffuse gliomas: RTK/Ras/PI3K/AKT signaling, TP53, RB pathways. Although these may affect tumor microenvironment, their association with immunotherapy biomarkers remains unclear. Methods: We used copy number variation mutation data to stratify patients specific signaling alterations, evaluated...
Immune checkpoint inhibitors have been shown to promote antitumor immunity and achieve durable tumor remissions. However, certain tumors are refractory current immunotherapy. These negative results encouraged us uncover other therapeutic targets strategies. PTPN2 (protein tyrosine phosphatase, non-receptor type 2) has newly identified as an immunotherapy target. Loss of sensitizes the via IFNγ signaling.Here, we investigated relationship between mRNA levels clinical characteristics in...
To identify biomarkers for accurate classification of glioma.We evaluated the heat shock protein 27 (Hsp27), phosphorylated Hsp27 (p-Hsp27), ATRX and IDH1R132Hproteins using immunohistochemistry in 421 glioma tissues. The χ2 test was used to assess relationship between molecular alterations clinico-pathological parameters. Kaplan-Meier survival curves were constructed, differences detected by log-rank test.We found that p-Hsp27 mainly expressed aggressive astrocytic gliomas. However, neither...
Background Skull base reconstruction is challenging due to its proximity important anatomical structures. This report evaluates the use of perforator flaps for skull defects after advanced recurrent tumor resection. Methods Fourteen free were transferred reconstruct in 14 consecutive patients, from October 2004 May 2011. All patients had neoplasms that previously treated with either radiation therapy or surgery. The surgical reconstructed using various mainly deep inferior epigastric artery...
Differentiating glioblastoma (GBM), brain metastases, and primary central nervous system lymphoma (PCNSL) in clinical practice is difficult. This study aimed to evaluate the diagnostic value of routine blood biomarkers patients with GBM, PCNSL find a preoperative differential tool for these tumors.The perioperative medical records 70 41 PCNSL, 81 metastases their test results were compared analyzed, model differentiate among them established.Patient age, plateletcrit, international...
The prognosis of breast cancer (BC) patients who develop into brain metastases (BMs) is very poor. Thus, it great significance to explore the etiology BMs in BC and identify key genes involved this process improve survival with BMs. gene expression data clinical information were downloaded from TCGA GEO database. Differentially expressed (DEGs) TCGA-BRCA GSE12276 overlapped find differentially metastatic (DEMGs). protein-protein interaction (PPI) network DEMGs was constructed via STRING...
Background: Studies have suggested that glioblastoma (GBM) cells originate from the subventricular zone (SVZ) and GBM contact with SVZ correlated worse prognosis higher recurrence. However, research on differentially expressed genes (DEGs) between is lacking. Methods: We performed deep RNA sequencing seven SVZ-involved GBMs paired tumor-free tissues. DEGs enrichment were assessed. obtained patient expression profiles clinical data Chinese Glioma Genome Atlas (CGGA) The Cancer (TCGA)...
Various hematological markers are associated with survival in patients glioblastomas (GBMs), as they reflect inflammation and nutrition status.However, single insufficient for predicting prognosis GBM, a comprehensive scoring system is needed.In this study, we developed simple, inexpensive, non-invasive system, referred to the Sanbo Scoring System (SSS), predict GBMs.Patients GBM were retrospectively assigned two independent cohorts at Brain Hospital National Cancer Center/Cancer...