A5015756887- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Renal Transplantation Outcomes and Treatments
- Colorectal and Anal Carcinomas
- Pharmacological Effects and Toxicity Studies
- Colorectal Cancer Screening and Detection
- Colorectal Cancer Surgical Treatments
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Cancer Cells and Metastasis
- Pharmacogenetics and Drug Metabolism
- Drug Transport and Resistance Mechanisms
- Molecular Biology Techniques and Applications
- Epigenetics and DNA Methylation
- Organ Transplantation Techniques and Outcomes
- Enhanced Recovery After Surgery
- Circadian rhythm and melatonin
- Renal cell carcinoma treatment
- Ferroptosis and cancer prognosis
Shanghai Medical College of Fudan University
2022-2024
Fudan University Shanghai Cancer Center
2021-2024
Shanghai Jiao Tong University
2014-2015
Renji Hospital
2014-2015
Abstract There is no effective method to predict chemotherapy response and postoperative prognosis of colorectal cancer liver metastasis (CRLM) patients. Patient‐derived organoid (PDO) has become an important preclinical model. Herein, a living biobank with 50 CRLM organoids derived from primary tumors paired metastatic lesions successfully constructed. PDOs the multiomics levels (histopathology, genome, transcriptome single‐cell sequencing) are comprehensively analyzed confirmed that this...
Background: Approximately 60% of patients with CRLM experience relapse within 2 years after radical resection, previous studies have proven that repeat local treatment (LT) could prolong survival, however, it is difficult to seize the window for LT due lack a high-sensitive surveillance method. In this study, we aim examine value longitudinal circulating tumor DNA (ctDNA) in guiding adjuvant chemotherapy (ACT), optimizing clinical strategy, and thereby improving outcomes. Materials Methods:...
Tacrolimus (TAC) is the backbone of an immunosuppressive drug used in most solid organ transplant recipients. A single nucleotide polymorphism (SNP) at position 6986G>A CYP3A5 has been notably involved pharmacokinetic variability TAC. It hypothesized that genotyping patients may provide a guideline for TAC therapeutic regimen. To further evaluate impact variants donors and recipients, ABCB1 ACE SNPs recipients on disposition, clinical laboratory data were retrospectively reviewed from 90...
Abstract Little information is available regarding the impact of cytochrome P450 ( CYP ) 3A5 on metabolism TAC in infant LTx. Therefore, genotype Chinese pediatric recipients (intestine) as well donors (graft liver) was performed for purpose establishing an optimal dosage regimen children. Sixty‐four patients were divided according to (expression *1 allele: EX and NEX each recipient (R) donor (D), ‐R/ ‐D (n = 21), 8), 8) 27). Results indicated that initial daily dose requirement higher among...
The purpose of the study was to evaluate impact single nucleotide polymorphisms (SNPs) Cytochrome P450 (CYP) 3A5 and adenosine triphosphate-binding cassette B1 (ABCB1) genotypes on TAC pharmacokinetics in Chinese paediatric patients.A total 136 liver recipients (R) their donors (D) were divided into groups according CYP3A5 [expression *1 allele: expressor (EX) or non-expressor (NEX)].Both recipient donor CYP3A5*1 alleles had impacts after transplantation. EX-R/EX-D required a significantly...
Abstract Background To study the pattern and treatment outcome of rectal cancer (RC) with concurrent locoregional recurrence (LR) distant metastasis (DM) after total mesorectal excision (TME) to identify patient-, disease-, treatment-related factors associated differences in prognosis LR DM. Methods RC patients who were diagnosed DM TME from May 2015 June 2019 included our study. All received single or multiple modalities under guidance multidisciplinary team (MDT) colorectal Fudan...
242 Background: Recurrence rates after curative intent resection of colorectal cancer liver metastases (CRLM) are nearly 50%. Standard care surveillance includes intensive computed tomographic (CT) imaging and CEA measurements. However, recurrence detection often happens too late to resume a second resection. Previous studies have shown that circulating tumor DNA (ctDNA) detection, as biomarker minimal residual disease (MRD), is robust prognostic factor for patients with cancers. Here, we...
e15614 Background: Mechanical anastomosis offers several advantages over traditional hand-sutured anastomosis. However, complications such as anastomotic leaks, strictures, and bleeding persist due to factors like interactions between staples tissue. Powered circular is an effective method address these issues. Currently, there are no domestic studies on the application of powered-anastomosis technology in colorectal Methods: The study adopted a multicenter, randomized, parallel-controlled,...
3037 Background: Although most cancer can benefit from early detection by more effective treatments and better prognosis, current screening programs are only limited to tumor-specific tests for a subset of common cancers. To broader population outweigh the risks single-cancer tests, an affordable multi-cancer test should be developed sensitive multiple cancers accurate prediction tissue origin simultaneously. Methods: In this study, we enrolled 971 patients prevalent lethal types, including...
Objective To compare the clinical efficacy of Freka trelumina (FT) vs. feeding jejunostomy (FJ) in carrying out postoperative early enteral nutrition (EEN) old patients with gastric cancer. Method 168 cancer cases were devided into FT group (n=54) EEN, FJ (n=50) tube and total parenteral (TPN) (n=64). Results Compared TPN group, body weight, serum albumin prealbumin level groups significantly higher, intestinal function recovery time, days hospitalization costs lower. The...
Objective Little information is available regarding the impact of cytochrome P450 (CYP) 3A5 on metabolism tacrolimus (TAC) in infant liver transplantation. Therefore, CYP3A5 genotype Chinese pediatric recipients (intestine) as well donors (graft liver) was analysed for purpose establishing an optimal dosage regimen children. Method Eighty-five patients treated with TAC were divided into following groups according to [expression *1 allele: expression (EX) and non-expression (NEX)] each...
Objective To investigate the efficacy and safety of enhanced recovery after surgery (ERAS) protocol in patients with gastric gastrointestinal stromal tumors (GISTs) favorable sites. Methods Between March 2015 January 2017, 86 GISTs undergoing laparoscopic resection sites were retrospectively analyzed. The divided into ERAS group (n=44) conventional (n=42). Perioperative data postoperative parameters compared. Results Compared group, such as time to first flatus , defecation,...
Abstract Objective To study the pattern and treatment outcome of rectal cancer (RC) with concurrent locoregional recurrence (LR) distant metastasis (DM) after total mesorectal excision (TME) to identify patient-, disease-, treatment-related factors associated differences in prognosis LR DM. Methods RC patients who were diagnosed DM TME from May 2015 June 2019 included our study. All received single or multiple modalities under guidance multidisciplinary team (MDT) colorectal Fudan University...