A5050051337- Immune Cell Function and Interaction
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Immune cells in cancer
- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Drug Transport and Resistance Mechanisms
- Hepatitis C virus research
- Liver Disease and Transplantation
- Drug-Induced Hepatotoxicity and Protection
- Liver physiology and pathology
- Atherosclerosis and Cardiovascular Diseases
- Insect Utilization and Effects
- Chemokine receptors and signaling
- Immune Response and Inflammation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer Immunotherapy and Biomarkers
- Autoimmune and Inflammatory Disorders Research
- Galectins and Cancer Biology
- Toxoplasma gondii Research Studies
- Urological Disorders and Treatments
- Parvovirus B19 Infection Studies
- Psoriasis: Treatment and Pathogenesis
- Mesenchymal stem cell research
- SARS-CoV-2 and COVID-19 Research
Renji Hospital
2013-2025
Shanghai Jiao Tong University
2013-2024
Zunyi Medical University
2011-2024
Shanghai Institute of Hematology
2022
Shanghai University
2021
Shuguang Hospital
2021
Shanghai University of Traditional Chinese Medicine
2021
Zhejiang University
2013
Sun Yat-sen University
2008
Institute of Entomology
2008
Epidemiological, preclinical and cellular studies in the last 5 years have shown that metformin exerts anti‐tumoral properties, but its mode of action cancer remains unclear. Here, we investigated effects on a mouse hepatocellular carcinoma (HCC) model tumor‐associated T cell immune responses. Oral administration led to significant reduction tumor growth, which was accompanied by decreased interleukin‐22 (IL‐22). Meanwhile, IL‐22‐induced STAT3 phosphorylation upregulation downstream genes...
Natural killer T (NKT) cells are the major early-acting immune cell type and fundamental modulators in ischemia-reperfusion injury (IRI). Because lymphocytes exposed to various oxygen tensions under pathophysiologic conditions, we hypothesize that hypoxia-inducible factors (HIFs) have roles NKT activation, thus determine final outcome of renal IRI. In this study, used Lck-Cre transgenic mice specifically disrupt HIF-2α T/NKT found knockout led upregulated Fas ligand expression on peripheral...
A remolded microenvironment in hepatocellular carcinoma (HCC) caused by abnormally expressed matricellular proteins could promote HCC progression. The cell-matrix interactions mediated integrins play an important role tumor microenvironment. Epidermal Growth Factor-like repeats and Discoidin I-Like Domains 3 (EDIL3), extracellular matrix (ECM) protein with angiogenic anti-inflammatory effects, is highly HCC. Here we aim to analyze its expression liver tissues, investigate the underlined...
Abstract Follicular helper T (T FH ) cells control antibody responses by supporting affinity maturation and memory formation. Inadequate function has been found in individuals with ineffective to vaccines, but the mechanism underlying regulation vaccination is not understood. Here, we report that lower serum levels of metabolic hormone leptin associate reduced vaccine influenza or hepatitis B virus vaccines healthy populations. Leptin promotes mouse human differentiation IL-21 production via...
OBJECTIVE: Although hepatitis B recurrence after liver transplantation has been reduced to 0%–10% since the application of combination therapy immunoglobulin (HBIG) and lamivudine, viral mutation resistance lamivudine is still an obstacle outcome transplantation. Here we evaluate role entecavir in preventing METHODS: Patients who received a for virus (HBV)‐related end‐stage disease our center from March 2006 December 2008 were enrolled this study. All patients (0.5 mg orally, daily) or (100...
Abstract Sirtuin 1 (Sirt1) is a deacetylase that regulates many cellular processes in the liver, and so far its role endotoxemic liver injury elusive. So we conditionally inactivate Sirt1 murine hepatocytes to determine d -galactosamine (GalN)/lipopolysaccharide (LPS)-induced damage, which well-established experimental model mimicking septic fulminant hepatitis. Ablation of shows remarkable protection against GalN/LPS-induced injury, result enhanced NF- κ B response because knockdown...
Background: Cell therapy demonstrates promising potential as a substitute therapeutic approach for liver cirrhosis. We have developed strategy to effectively expand murine and human hepatocyte-derived progenitor-like cells (HepLPCs) in vitro. The primary objective of the present study was apply HepLPCs treatment cirrhosis elucidate underlying mechanisms responsible their efficacy. Methods: effects allogeneic or xenogeneic HepLPC transplantation were investigated rat model Liver tissues...
The immunosuppressive tumor microenvironment (TME) plays an essential role in cancer progression and immunotherapy response. Despite the considerable advancements immunotherapy, limited response to immune checkpoint blockade (ICB) therapies patients with hepatocellular carcinoma (HCC) remains a major challenge for its clinical implications. Here, we investigated molecular basis of protein O-fucosyltransferase 1 (POFUT1) that drives HCC evasion explored potential therapeutic strategy...
Abstract Background Acute liver failure (ALF) is a complicated condition that characterized by global hepatocyte death and often requires immediate transplantation. However, this therapy limited shortage of donor organs. Mesenchymal stem cells (MSCs) hepatocytes are two attractive sources cell-based therapies to treat ALF. The combined transplantation MSCs considered be more effective for the treatment ALF than single-cell We have previously demonstrated HNF4α-overexpressing human umbilical...
Tacrolimus (TAC) is the backbone of an immunosuppressive drug used in most solid organ transplant recipients. A single nucleotide polymorphism (SNP) at position 6986G>A CYP3A5 has been notably involved pharmacokinetic variability TAC. It hypothesized that genotyping patients may provide a guideline for TAC therapeutic regimen. To further evaluate impact variants donors and recipients, ABCB1 ACE SNPs recipients on disposition, clinical laboratory data were retrospectively reviewed from 90...
Background & AimsChemokine-mediated immune cell recruitment plays pivotal roles in liver inflammation. C-C motif chemokine ligand 5 (CCL5) has been shown to be responsible for the of monocytes/macrophages and implicated various diseases, including nonalcoholic fatty disease, fibrosis, hepatocellular carcinoma. Previous studies have also that inhibition CCL5 appears a promising therapeutic approach several chronic diseases. However, whether blocking could benefit cell–mediated hepatitis...
The purpose of the study was to evaluate impact single nucleotide polymorphisms (SNPs) Cytochrome P450 (CYP) 3A5 and adenosine triphosphate-binding cassette B1 (ABCB1) genotypes on TAC pharmacokinetics in Chinese paediatric patients.A total 136 liver recipients (R) their donors (D) were divided into groups according CYP3A5 [expression *1 allele: expressor (EX) or non-expressor (NEX)].Both recipient donor CYP3A5*1 alleles had impacts after transplantation. EX-R/EX-D required a significantly...
Ex vivo gene manipulation in human hepatocytes is a promising therapeutic strategy the treatment of inherited liver diseases. However, major limitation lack highly efficient and safe genetic system for transplantable primary (PHHs). Here, we reported that proliferating (ProliHHs) cultured vitro showed high susceptibility to lentivirus-mediated modification maintained cellular phenotypes after lentiviral infection. Human factor VIII expression was introduced through F8-Lentivirus-mediated...
Objectives The hospitalization and mortality rate from COVID-19 appears to be higher in liver transplant recipients when compared with general populations. Vaccination is an effective strategy reduce the risk during pandemic. We aimed evaluate vaccine hesitancy recipients. Methods In April 2022, we conducted online-based survey through WeChat platform investigate vaccination among followed at Shanghai Renji Hospital further explore possible influencing factors. Survey items included multiple...
Human umbilical cord mesenchymal stem/stromal cells (hUMSCs) hold promise for treating acute liver failure (ALF). Here, we investigated the therapeutic effect of hUMSCs overexpressing hepatocyte nuclear factor 4α (HNF4α), a transcription important maintaining identity and hepatic functions, in ALF, compared with without overexpression HNF4α (CON‐hUMSCs). The were administered into mice via tail vein 24 h before exposure to lipopolysaccharide/ d ‐galactosamine (LPS/ ‐GalN) 6 by...