A5101599353- Virus-based gene therapy research
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- RNA Interference and Gene Delivery
- Medicinal Plant Pharmacodynamics Research
- Pharmacological Effects of Natural Compounds
- Phytochemicals and Antioxidant Activities
- biodegradable polymer synthesis and properties
- Advanced Cellulose Research Studies
- Protein Hydrolysis and Bioactive Peptides
- RNA modifications and cancer
- Biochemical and Molecular Research
- Fungal Biology and Applications
- Immune Response and Inflammation
- Biofuel production and bioconversion
- Single-cell and spatial transcriptomics
- CRISPR and Genetic Engineering
- Phytochemistry and Biological Activities
- Polysaccharides and Plant Cell Walls
- Trypanosoma species research and implications
- MXene and MAX Phase Materials
- Kruppel-like factors research
- Antioxidant Activity and Oxidative Stress
- Aquaculture Nutrition and Growth
- Cancer, Lipids, and Metabolism
University of Science and Technology of China
2025
Guangzhou University of Chinese Medicine
2013-2025
Qiqihar University
2011-2025
Wannan Medical College
2025
Anhui Medical University
2024
Tengzhou Central People's Hospital
2024
Second Affiliated Hospital of Nanchang University
2024
Nanchang University
2024
Harbin Institute of Technology
2019-2024
Chinese PLA General Hospital
2022-2023
Gendicine (recombinant human p53 adenovirus), developed by Shenzhen SiBiono GeneTech Co. Ltd., was approved in 2003 the China Food and Drug Administration (CFDA) as a first-in-class gene therapy product to treat head neck cancer, entered commercial market 2004. is biological that delivered via minimally invasive intratumoral injection, well intracavity or intravascular infusion. The wild-type (wt) protein expressed Gendicine-transduced cells tumor suppressor activated cellular stress,...
Separation of complex protein mixtures that have a wide dynamic range concentration, such as plasma or serum, is challenge for proteomic analysis. Sample preparation to remove high-abundant proteins essential proteomics Immunoglobulin yolk (IgY) antibodies unique and advantageous features enable specific removal aid in the detection low-abundant biomarker discovery. This report describes efficiency effectiveness IgY microbeads separating 12 abundant from with an immunoaffinity spin column LC...
Contrast-induced acute kidney injury (CI-AKI) causes clinically acquired nephropathy in patients who undergo coronary interventions. Hypoxic to proximal tubular epithelial cells is a pathological mechanism of CI-AKI. Previous studies have shown that hypoxia activates HIF-1α/HE4/NF-κB enhance renal fibrosis, and the SGLT-2 inhibitor luseogliflozin inhibits hypoxia-inducible factor (HIF)-1α expression reduce progression diabetic nephropathy. However, therapeutic effects mechanisms inhibitors...
Epidemiological, preclinical and cellular studies in the last 5 years have shown that metformin exerts anti‐tumoral properties, but its mode of action cancer remains unclear. Here, we investigated effects on a mouse hepatocellular carcinoma (HCC) model tumor‐associated T cell immune responses. Oral administration led to significant reduction tumor growth, which was accompanied by decreased interleukin‐22 (IL‐22). Meanwhile, IL‐22‐induced STAT3 phosphorylation upregulation downstream genes...
Abstract Plant trichomes serve as a highly suitable model for investigating cell differentiation at the single‐cell level. The regulatory genes involved in unicellular trichome development Arabidopsis thaliana have been intensively studied, but regulating multicellular plants remain unclear. Here, we characterized Cucumis sativus (cucumber) representative and unbranched structures, identified Micro‐trichome ( Mict ), using map‐based cloning an F 2 segregating population of 7,936 individuals...
In preparation for a clinical trial of the recombinant p53 adenovirus Ad5CMV-p53 treatment lung cancer, potential adverse effects were assessed in vitro and vivo. No infectious replication was detectable HeLa cells infected with extracts from previously Ad5CMV-p53. DNA detected by 32Pi labeling cancer at multiplicities infection (moi) up to 1,000 pfu/cell (total 5 x 10(9) pfu viruses). The infectivity cytotoxicity examined normal human bronchial epithelial (NHBE) cells. At moi 50 pfu/cell,...
The transcription factor, early growth response 1 (EGR1), has important roles in various cell types to different stimuli. EGR1 is thought be involved differentiation of bovine skeletal muscle-derived satellite cells (MDSCs); however, the precise effects on MDSCs and its mechanism action remain unknown. In present study, a time course expression MDSC were determined. results demonstrated that mRNA protein increased significantly differentiating relative proliferating cells. Over-expression...
The dysregulation of T cell differentiation was associated with cognitive impairment. Recently, the peripheric β-secretase (BACE1) has been suggested as a regulator differentiation, which increased in both impairment (CI) and type 2 diabetes mellitus (T2DM) CI patients. However, relationship between dysfunction remains unclear. To address this question, we measured subtypes BACE1 enzyme activity clinical cohort 5xFAD mice. We found that IFNγ+ Th1 Tc1 cells were T2DM-CI groups, worsening...
Environmental issues have prompted the vigorous development of biorefineries that use agricultural waste and other biomass feedstock as raw materials. However, most current biorefinery products are cellulosic ethanol. There is an urgent need for to expand into new bioproducts. Isobutanol important bulk chemical with properties close gasoline, making it a very promising biofuel. The microorganisms produce isobutanol has been extensively studied, but there still considerable gap achieving...
To evaluate the applicability of recombinant adenoviral vectors in gene transfer to liver cancers, we infused adenoviruses AD5CMV-LacZ and Ad5CMV-p53 through portal veins into two lines transgenic mice, one bearing SV40 T antigen other human hepatitis B viral envelope protein. These animals develop hepatocellular carcinomas (HCC) with predictable pathological manifestations. The levels expression transgenes were dependent upon doses. In all cases, high detected within 2 or 3 days after...