A5070162145- Acute Kidney Injury Research
- Chronic Kidney Disease and Diabetes
- Acute Myocardial Infarction Research
- Cardiovascular Function and Risk Factors
- Pulmonary Hypertension Research and Treatments
- Cardiac Imaging and Diagnostics
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Coronary Interventions and Diagnostics
- Heart Failure Treatment and Management
- Cancer-related molecular mechanisms research
- Cardiac Arrest and Resuscitation
- Cardiac electrophysiology and arrhythmias
- Sepsis Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Eicosanoids and Hypertension Pharmacology
- Cancer, Hypoxia, and Metabolism
- Renal and Vascular Pathologies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Circular RNAs in diseases
- Nitric Oxide and Endothelin Effects
- Inflammatory Biomarkers in Disease Prognosis
- Ion channel regulation and function
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Protease and Inhibitor Mechanisms
Zhongda Hospital Southeast University
2016-2025
Southeast University
2013-2025
Zhejiang University
2025
Alibaba Group (China)
2024
Weatherford College
2020
Wuhan University
2016
Renmin Hospital of Wuhan University
2016
Jiangsu Province Hospital
2001
Nanjing Medical University
2001
Abstract Background Insulin resistance (IR) is considered a pivotal risk factor for cardiometabolic diseases, and the triglyceride–glucose index (TyG index) has emerged as reliable surrogate marker of IR. Although several recent studies have shown association TyG with vascular disease, no further investigated role in acute ST-elevation myocardial infarction (STEMI). The objective present study was to evaluate potential predictor prognosis STEMI patients after percutaneous coronary...
Background Endothelial dysfunction, a hallmark of diabetes, is critical and initiating contributor to the pathogenesis diabetic cardiovascular complications. However, underlying mechanisms are still not fully understood. Ferroptosis newly defined regulated cell death driven by cellular metabolism iron-dependent lipid peroxidation. Although involvement ferroptosis in disease has been shown cancers degenerative diseases, participation endothelial dysfunction remains unclear. Aim To examine...
Contrast-induced acute kidney injury (CI-AKI) causes clinically acquired nephropathy in patients who undergo coronary interventions. Hypoxic to proximal tubular epithelial cells is a pathological mechanism of CI-AKI. Previous studies have shown that hypoxia activates HIF-1α/HE4/NF-κB enhance renal fibrosis, and the SGLT-2 inhibitor luseogliflozin inhibits hypoxia-inducible factor (HIF)-1α expression reduce progression diabetic nephropathy. However, therapeutic effects mechanisms inhibitors...
Abstract Background Abnormal lipid metabolism poses a risk for prediabetes. However, research on parameters used to predict the of prediabetes is scarce, and significance traditional untraditional remains unexplored in This study aimed comprehensively evaluate association between 12 their diagnostic value. Methods cross-sectional included data from 100,309 Chinese adults with normal baseline blood glucose levels. New onset was outcome concern. Untraditional were derived parameters....
Background and Objectives Triglyceride-glucose (TyG) is an emerging vital indicator of insulin resistance associated with increased risk T2DM cardiovascular events. We aimed to explore the TyG index contrast-induced acute kidney injury (CI-AKI) in patients type 2 diabetes who underwent coronary angiology. Methods This study enrolled 928 suspected artery disease angiology or percutaneous intervention Zhongda hospital. Patient data were divided into quartiles according index: group 1: ≤ 8.62;...
The fluxonium qubits have emerged as a promising platform for gate-based quantum information processing. However, their extraordinary protection against charge fluctuations comes at cost: when coupled capacitively, the qubit-qubit interactions are restricted to XX interactions. Consequently, effective ZZ or XZ only constructed either by temporarily populating higher-energy states, exploiting perturbative effects under microwave driving. Instead, we propose and demonstrate an inductive...
The present study aimed to evaluate the predictive role of inflammatory biomarkers in development contrast-induced acute kidney injury (CI-AKI) coronary syndrome (ACS) patients undergoing percutaneous intervention (PCI). assessed were: platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte (MLR), neutrophil-to-lymphocyte (NLR), derived (dNLR), neutrophil-to-lymphocyte*platelet (NLPR), systemic index (SII), and inflammation response (SIRI). Overall, 950 PCI were enrolled. frequency CI-AKI...
An increasing number of mechano-sensitive ion channels in endothelial cells have been identified response to blood flow and hydrostatic pressure. However, how these respond under different physiological pathological conditions remains unknown. Our results show that epithelial Na(+) (ENaCs) colocalize with hemeoxygenase-1 (HO-1) hemeoxygenase-2 (HO-2) within the caveolae on apical membrane are sensitive stretch pressure shear stress. ENaCs exhibited low levels activity until their environment...
At present, the long-term prognosis of patients with acute myocardial infarction (AMI) after emergency percutaneous coronary intervention is focus attention, and relevant research actively investigating risk factors associated prognosis. Poor often exists in Patients AMI complicated heart failure (AHF). In recent years, some studies have found that blood urea nitrogen/creatinine ratio (BUN/Cr) can better predict AHF than single BUN or Cr. The relationship between long-prognosis AMI, as one...
Metabolic dysfunction-associated steatotic liver disease (MASLD) is one of the most prevalent diseases and associated with pre-hypertension hypertension. Our research aims to develop interpretable machine learning (ML) models accurately identify MASLD in hypertensive pre-hypertensive populations.
Purpose . Metabolic syndrome (MetS) is closely related to insulin resistance (IR), and the sex differences have not been fully explored. This study was aimed investigate in associations among IR indexes with MetS a large population. Methods A total of 60,799 participants were enrolled current study. defined using National Cholesterol Education Program Adult Treatment Panel III criteria. The following evaluated: triglyceride‐glucose (TyG) index, TyG‐waist circumference (TyG‐WC), height ratio...
Coronary artery ectasia (CAE) is the aneurysmal dilatation of coronary artery, recognized as a special clinical form stenosis besides atherosclerosis. Its exact pathophysiological mechanism remains unknown. Moreover, few studies have focused on relationship between triglyceride and CAE. We aimed to find risk factors for CAE analyze serum lipid CAE.We conducted prospective cohort study patients admitted because typical or atypical chest discomfort suggestive angina in Zhongda Hospital...
Previous studies showed that fibrinogen-to-albumin ratio (FAR) regarded as a novel inflammatory and thrombotic biomarker was the risk factor for coronary artery disease (CAD). In this study, we sought to evaluate relationship between FAR severity of CAD, long-term prognosis in non-ST elevation acute syndrome (NSTE-ACS) patients firstly implanted with drug-eluting stent (DES). A total 1138 consecutive NSTE-ACS DES from January 2017 December 2018 were recruited study. Patients divided into...
Background Triglyceride-glucose (TyG) index is a reliable and specific biomarker for insulin resistance associated with renal dysfunction. The present study sought to explore the relationship between TyG incidence of contrast-induced nephropathy (CIN) in non-ST elevation acute coronary syndrome (NSTE-ACS) patients implanted drug-eluting stents (DESs). Methods A total 1108 participants were recruited assigned two groups based on occurrence CIN. was calculated as ln [fasting triglycerides...
The objective of this study was to construct a prediction model assess the onset acute heart failure (AHF) in patients with chronic obstructive pulmonary disease (COPD) without history and evaluate predictive value nomogram. This involved 3,730 COPD no failure. Clinical laboratory data were collected from Medical Information Mart for Intensive Care IV (MIMIC-IV) database. divided into training set (2,611 cases) validation (1,119 7:3 ratio. Least absolute shrinkage selection operator (LASSO)...
Fluxonium qubits are recognized for their high coherence times and operation fidelities. These attributed to unique design incorporating a superinductor, which is typically implemented using an array of over 100 Josephson junctions; however, this complexity poses significant fabrication challenges, particularly in achieving yield junction uniformity with traditional methods. Here, we introduce overlap process Josephson-junction that achieves nearly 100% maintains across 2-inch (50.8-mm)...
Pulmonary hypertension (PH) is a chronic and life-threatening disease characterized by pulmonary vascular remodeling (PVR), which involves the abnormal proliferation of artery smooth muscle cells (PASMCs). These exhibit metabolic characteristics akin to cancer cells, particularly in their shift towards glycolysis. The Lon protease 1 (LONP1) has been shown promote glycolytic reprogramming tumor conferring malignant proliferative phenotype. However, precise role LONP1 PH remains unclear. In...