A5101420326- Cancer, Hypoxia, and Metabolism
- Cancer-related gene regulation
- Histone Deacetylase Inhibitors Research
- Epigenetics and DNA Methylation
- Prostate Cancer Treatment and Research
- Protein Degradation and Inhibitors
- Immune Cell Function and Interaction
- interferon and immune responses
- T-cell and B-cell Immunology
- Galectins and Cancer Biology
- Endoplasmic Reticulum Stress and Disease
- Chromatin Remodeling and Cancer
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Inflammasome and immune disorders
- Hair Growth and Disorders
- Acute Lymphoblastic Leukemia research
- Autophagy in Disease and Therapy
- Microbial metabolism and enzyme function
- Inflammatory Bowel Disease
- RNA Research and Splicing
- Cancer Research and Treatments
- Ferroptosis and cancer prognosis
- Pneumonia and Respiratory Infections
- Cytokine Signaling Pathways and Interactions
Guangzhou University
2022-2023
Huazhong University of Science and Technology
2022
Tongji Hospital
2022
Shanghai Jiao Tong University
2017-2021
Shanghai First People's Hospital
2021
Chinese Academy of Sciences
2017-2018
Shanghai Institutes for Biological Sciences
2017-2018
Center for Excellence in Molecular Cell Science
2017-2018
Air Force Medical University
2013-2018
Shanghai Institute of Nutrition and Health
2018
Abstract To overcome chemotherapy resistance, novel strategies sensitizing cancer cells to are required. Here, we screen the lysyl-oxidase (LOX) family clarify its contribution resistance in liver cancer. LOXL3 depletion significantly sensitizes Oxaliplatin by inducing ferroptosis. Chemotherapy-activated EGFR signaling drives interact with TOM20, causing it be hijacked into mitochondria, where activity is reinforced phosphorylation at S704. Metabolic adenylate kinase 2 (AK2) directly...
Loss of phosphatase and tensin homolog (PTEN) activation the PI3K/AKT signaling pathway are hallmarks prostate cancer (PCa). However, these alterations alone insufficient for cells to acquire metastatic traits. Here, we have shown that histone dimethyl transferase WHSC1 critically drives indolent PTEN-null tumors become PCa. In a murine PCa model, overexpression in epithelium cooperated with Pten deletion produce metastasis-prone tumor. Conversely, genetic ablation Whsc1 prevented tumor...
Significance TNFα is the key cytokine implicated in inflammatory bowel disease. However, not always proinflammatory, because TNFα-activated NF-κB induces prosurvival proteins, including c-FLIP, to constrain caspase 8 activation. Here we report that epithelial EZH2 integrates multifaceted effects of signaling promote inflammation and apoptosis colitis. reduction directly stimulates TRAF2/5 expression enhance TNFα-induced signaling. More importantly, deficiency up-regulates E3 ligase ITCH...
Loss of phosphatase and tensin homolog (PTEN) represents one hallmark prostate cancer (PCa). However, restoration PTEN or inhibition the activated PI3K/AKT pathway has shown limited success, prompting us to identify obligate targets for disease intervention. We hypothesized that loss might expose cells unique epigenetic vulnerabilities. Here, we identified a synthetic lethal relationship between Brahma-related gene 1 (BRG1), an ATPase subunit SWI/SNF chromatin remodeling complex. Higher BRG1...
Prostate cancer (PCa), an inert tumour, has a long progression period, but valid biomarkers and methods for effectively sensitively monitoring PCa are lacking, prompting us to identify new predictors diagnosis prognosis. Posttranslational modifications characterizing receptor activation considered potentially strong indicators of disease progression.The posttranscriptional regulation leukaemia inhibitory factor (LIFR) its novel downstream signalling activity in were studied using liquid mass...
Metastatic disease is the leading cause of death due to prostate cancer (PCa). Although hypermethylated in 1 (HIC1) gene has been observed be epigenetically modified PCa, its intrinsic role and mechanism PCa metastasis still remain uncertain. Here, we show that hypermethylation HIC1 promoter markedly reduces suppressive function metastatic tissues as compared with primary adjacent normal tissues, associated poor patient survival. PCas cancer-prone mice homozygous for a prostate-targeted Hic1...
Summary This study examined the expression of inhibitory receptor, leucocyte-associated immunoglobulin (Ig)-like receptor-1 (LAIR-1) in fibroblast-like synoviocytes (FLS) rheumatoid arthritis (RA) patients to investigate its potential role modulation inflammatory cytokines, matrix metalloproteinases (MMPs) and invasiveness synoviocytes. LAIR-1 synovial tissues from RA patients, osteoarthritis healthy donors was analysed by immunohistochemistry. The membrane-bound form (mLAIR-1) detected flow...
Objective: The aim of this study was to investigate the cost-effectiveness olaparib as maintenance therapy in patients with platinum-sensitive relapsed ovarian cancer and a BRCA1/2 mutation China. Methods: A Markov model developed simulate clinical course typical SOLO2 trial. Weibull survival employed fit Kaplan–Meier progression-free overall probabilities placebo strategies, respectively. direct costs data were derived from randomized trials published reports. Quality-adjusted life-years...
To investigate the correlation between dehydrogenases and hypoxia response, we used siRNA targeting 134 dehydrogenase-coding genes in HCT116 cells discovered that glutamate dehydrogenase 1 (GDH1) plays a role regulating cell survival under hypoxia. α-Ketoglutarate (αKG) is an important biological compound involved formation of amino acids, nitrogen transport, oxidation reactions. There no clear association αKG colorectal cancer (CRC), especially as underlying molecular mechanisms...