A5076469966- RNA modifications and cancer
- Circular RNAs in diseases
- Prostate Cancer Treatment and Research
- Cancer-related molecular mechanisms research
- Renal cell carcinoma treatment
- Ferroptosis and cancer prognosis
- Retinoids in leukemia and cellular processes
- Renal and related cancers
- Acute Myeloid Leukemia Research
- Prostate Cancer Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- Peptidase Inhibition and Analysis
- Cancer-related gene regulation
- Cancer Cells and Metastasis
- Urologic and reproductive health conditions
- Bladder and Urothelial Cancer Treatments
- Radiopharmaceutical Chemistry and Applications
- Cell Adhesion Molecules Research
- Molecular Biology Techniques and Applications
- RNA Research and Splicing
- Protein Degradation and Inhibitors
- Single-cell and spatial transcriptomics
Fudan University Shanghai Cancer Center
2015-2024
Shanghai Medical College of Fudan University
2013-2024
Shanghai Cancer Institute
2022-2024
Taiyuan University of Technology
2024
ZTE (China)
2024
Fudan University
2023-2024
Beijing University of Chemical Technology
2018-2023
Obstetrics and Gynecology Hospital of Fudan University
2019-2022
The University of Texas MD Anderson Cancer Center
1990-2014
Huazhong Agricultural University
2013
Abstract The KEAP1-NRF2 axis is the principal regulator of cellular responses to oxidative and electrophilic stressors. NRF2 hyperactivation frequently observed in many types cancer promotes initiation, progression, metastasis, resistance various therapies. Here, we determined that dipeptidyl peptidase 9 (DPP9) a pathway clear cell renal carcinoma (ccRCC). DPP9 was markedly overexpressed at mRNA protein levels ccRCC, high expression correlated with advanced tumor stage poor prognosis...
Abstract In recent years, the environmental health issue of microplastics has aroused an increasingly significant concern. Some studies suggested that exposure to polystyrene (PS-MPs) may lead renal inflammation and oxidative stress in animals. However, little is known about essential effects PS-MPs with high-fat diet (HFD) on development microenvironment. this study, we provided single-cell transcriptomic landscape kidney microenvironment induced by HFD mouse models unbiased RNA sequencing...
This study aimed to investigate the role of AR-V7 in development castration-resistant prostate cancer (CRPC) and determine whether expression CRPC tissues can predict cancer-specific survival. We enrolled 100 localized (PCa) (cohort 1), 104 newly diagnosed metastatic PCa 2) 46 3) patients treated at our institution. The was assessed by immunohistochemistry. Cox regression models were used evaluate predictive all covariates for cohort 2 survival 3. Time curves estimated using Kaplan-Meier...
Abstract The tumorigenic role and underlying mechanisms of lipid accumulation, commonly observed in many cancers, remain insufficiently understood. In this study, we identified an AMP-activated protein kinase (AMPK)–GATA-binding 3 (GATA3)–enoyl-CoA hydratase short-chain 1 (ECHS1) pathway that induces accumulation promotes cell proliferation clear renal carcinoma (ccRCC). Decreased expression ECHS1, which is responsible for inactivation fatty acid (FA) oxidation activation de novo FA...
Abstract Background The gene encoding the E3 ubiquitin ligase substrate-binding adaptor SPOP is frequently mutated in primary prostate cancer, but how mutations contribute to cancer pathogenesis remains poorly understood. Stress granules (SG) assembly an evolutionarily conserved strategy for survival of cells under stress, and often upregulated human cancers. We investigated role aberrant activation SG explored relevanve mechanism therapy resistance. Methods identified nucleating protein...
Recent studies have discovered that tiny particles of microplastics (MPs) at the nano-scale level can enter body organisms from environment, potentially causing metabolic ailments. However, further investigation is required to understand alterations in immune microenvironment associated with non-alcoholic fatty liver disease (NAFLD) occurrence following exposure MPs. Experiments were performed using mice, which given a normal chow or high-fat diet (NCD HFD, respectively) plus free drinking...
Abstract Tertiary lymphoid structures (TLS) are organized aggregates of immune cells that form under pathological conditions. However, the predictive value TLS in clear cell renal carcinoma (ccRCC) for immunotherapies remains unclear. We comprehensively assessed implications prognosis and immunological responses spatial maturation heterogeneity 655 ccRCC patients. A higher proportion early‐TLS was found peritumoral TLS, while intratumoral mainly comprised secondary follicle‐like (SFL‐TLS),...
We identified a novel chicken actin gene. The protein deduced from its nucleotide sequence very closely resembles the vertebrate cytoplasmic actins; accordingly, we classified this gene as nonmuscle type. adopted convention for indicating actins of class Amphibia (Vandekerckhove et al., J. Mol. Biol. 152:413-426) and denoted type 5. RNA blot analysis demonstrated that 5 mRNA transcripts accumulate in adult tissues pattern indicative Genomic DNA blots indicated is single copy distinct member...
Utilizing novel approaches for the green synthesis of metal nanoparticles are great importance. Therefore, we reported biogenic silver (AgNPs) using extracts Leptolyngbya strain JSC-1, and their significant applications against pathogenic bacteria cancerous HeLa cell line. The biofabricated AgNPs were characterized by UV–visible spectroscopy, FTIR, SEM, TEM, DLS zeta-potential. as prepared assessed inhibition bacterial growth induction apoptosis in cells different doses was evaluated....
Next-generation sequencing of the exome and genome prostate cancers has identified numerous genetic alterations. SPOP (Speckle-type POZ Protein) is one most frequently mutated genes in primary cancer, suggesting that may be a potential driver cancer. The aim this work was to investigate how mutations contribute cancer development progression.To identify molecular mediators tumor suppressive function SPOP, we performed yeast two-hybrid screen HeLa cDNA library using full-length as bait....
The pathologic significance of the circular RNA DDIT4 (circDDIT4), which is formed by backsplicing at 3'-untranslated region (UTR) with a 5' splice acceptor site in exon 2 linear mRNA, has yet to be determined. Our study found that circDDIT4 downregulated prostate cancer and functions as tumor suppressor during progression. By competitively binding ELAV-like protein 1 (ELAVL1/HuR) through its 3'-UTR, acts sponge decrease expression cancer-overexpressed anoctamin 7 (ANO7). This promotes cell...
Our previous studies demonstrated that PML is a growth suppressor suppresses oncogenic transformation of NIH/3T3 cells and rat embryo fibroblasts. nuclear matrix-associated phosphoprotein whose expression regulated during the cell cycle. Disruption function by t(15;17) in acute promyelocytic leukemia (APL) plays critical role leukemogenesis. To further study control growth, we have stably overexpressed protein HeLa line. This overexpression significantly reduced rate suppressed...
We sequenced the entire chicken α-cardiac actin gene. A single intron was positioned 20 bp upstream from initiation ATG codon in 5′ non-coding region while coding interrupted by 5 introns at amino acid positions 41/42, 150, 204, 267, and 327/328.Sequencing allowed first comparison of α-skeletal transcriptional promoters. These highly G+C rich promoters share two regions homology which are found position −134 (10 bp) end −296 (12 promoter. smaller 9 motif (CCGCCCCGG) homologous to sequence...
Genes representing six different actin isoforms were isolated from a chicken genomic library. Cloned cDNAs as well tissue-specific mRNAs enriched in species used hybridization probes to group individual clones by their relative thermal stability. Restriction maps showed that these genes derived separate and nonoverlapping regions of DNA. Of the genes, five included sequences both 5' 3' ends actin-coding area. Amino acid sequence analysis NH2- COOH-terminal provided for unequivocal...
To investigate the clinicopathological features, therapeutic strategies, and prognostic factors of patients with penoscrotal invasive extramammary Paget's disease (EMPD).We retrospectively collected clinical, pathological, follow-up data 56 men EMPD. Histopathological features primary skin lesion including tumour size, surgical margin status, depth invasion lymphovascular were examined.The median age was 67 years longest diameter 5 cm. All treated wide excision 22 clinically positive...
Clear cell renal carcinoma (ccRCC) is the most common adult neoplasm and its incidence continues to increase. Collagen abundant extracellular matrix protein in stroma, contributes development progression of ccRCC. We examined human collagen type XXIII α1 chain (COL23A1) expression ccRCC relationship between COL23A1 patients' survival. found mRNA was elevated tumor compared with adjacent normal tissues, which further validated by TCGA cohort. IHC results from 151 cases suggested that high...
Abstract This study aimed to assess the utility of transcription factor E3 (TFE3) break-apart fluorescence in situ hybridization (FISH) assay diagnosis Xp11.2 translocation renal cell carcinoma (Xp11.2 RCC) and compare clinicopathological features between adult RCC non-Xp11.2 RCC. 76 pathologically suspected RCCs were recruited from our institution. Both TFE3 immunohistochemistry (IHC) FISH performed for entire cohort. The progression-free survival (PFS) overall (OS) curves estimated using...
Upper tract urothelial carcinoma (UTUC) is often diagnosed late and exhibits poor prognosis. Limited data are available on potential non-invasive biomarkers for disease monitoring. Here, we investigate the proteomic profile of plasma in 362 UTUC patients 239 healthy controls. We present an integrated tissue-plasma approach to infer signature proteins identifying with muscle-invasive UTUC. discover a protein panel that reflects lymph node metastasis, which interest high risk also identify...
// Kun Chang 1,2,* , Yun-Yi Kong 2,3,* Bo Dai 1,2 Ding-Wei Ye Yuan-Yuan Qu Yue Wang Zhong-Wei Jia and Gao-Xiang Li 1 Department of Urology, Fudan University Shanghai Cancer Center, University, Shanghai, China 2 Oncology, Medical College, 3 Pathology, * Co-first author Correspondence to: Dai, email: Ye, Keywords : circulating tumor cell, epithelial-mesenchymal transition, metastatic castration-resistant prostate cancer, prognosis, stem cell Received August 05, 2015 Accepted October 04,...
Among all types of renal cancer, clear cell carcinoma (ccRCC) is the most common and lethal subtype associated with a high risk metastasis recurrence. Histone modifications regulate several biological processes that are fundamental to development cancer. Lysine methyltransferase 5C (KMT5C; also known as SUV420H2) an epigenetic modifier responsible for trimethylation H4K20, which drives critical cellular events, including genome integrity, growth epithelial‑mesenchymal transition (EMT), in...