A5006239432- Helicobacter pylori-related gastroenterology studies
- Galectins and Cancer Biology
- CAR-T cell therapy research
- Monoclonal and Polyclonal Antibodies Research
- Prostate Cancer Treatment and Research
- Cancer Research and Treatments
- Biosimilars and Bioanalytical Methods
- Virus-based gene therapy research
- Cancer Immunotherapy and Biomarkers
- Veterinary medicine and infectious diseases
- Gastric Cancer Management and Outcomes
- Viral Infectious Diseases and Gene Expression in Insects
- Glycosylation and Glycoproteins Research
- Ferroptosis and cancer prognosis
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- Advanced Biosensing Techniques and Applications
- Thyroid Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Lung Cancer Diagnosis and Treatment
- Prostate Cancer Diagnosis and Treatment
- Cancer-related gene regulation
- Escherichia coli research studies
- Cystic Fibrosis Research Advances
- Eosinophilic Esophagitis
Mayo Clinic
2017-2024
Jiangxi Agricultural University
2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2024
Chongqing Medical University
2024
Stomatological Hospital of Chongqing Medical University
2024
Peking University First Hospital
2023
Peking University
2023
Weill Cornell Medicine
2017-2023
Cornell University
2013-2023
Cangzhou Central Hospital
2015-2023
Abstract Copper serves as a co-factor for host of metalloenzymes that contribute to malignant progression. The orally bioavailable copper chelating agent tetrathiomolybdate (TM) has been associated with significant survival benefit in high-risk triple negative breast cancer (TNBC) patients. Despite these promising data, the mechanisms by which depletion impacts metastasis are poorly understood and this remains major barrier advancing TM randomized phase II trial. Here, using two independent...
Abstract Background The gene encoding the E3 ubiquitin ligase substrate-binding adaptor SPOP is frequently mutated in primary prostate cancer, but how mutations contribute to cancer pathogenesis remains poorly understood. Stress granules (SG) assembly an evolutionarily conserved strategy for survival of cells under stress, and often upregulated human cancers. We investigated role aberrant activation SG explored relevanve mechanism therapy resistance. Methods identified nucleating protein...
Biomarkers aiding treatment optimization in metastatic castration-resistant prostate cancer (mCRPC) are scarce. The presence or absence of androgen receptor (AR) splice variants, AR-V7 and AR
Purpose The TAXYNERGY trial ( ClinicalTrials.gov identifier: NCT01718353) evaluated clinical benefit from early taxane switch and circulating tumor cell (CTC) biomarkers to interrogate mechanisms of sensitivity or resistance taxanes in men with chemotherapy-naïve, metastatic, castration-resistant prostate cancer. Patients Methods were randomly assigned 2:1 docetaxel cabazitaxel. Men who did not achieve ≥ 30% prostate-specific antigen (PSA) decline by cycle 4 (C4) switched taxane. primary...
Abstract Purpose: Intratumoral androgen synthesis (IAS) is a key mechanism promoting receptor (AR) reactivation and antiandrogen resistance in castration-resistant prostate cancer (CRPC). However, signaling pathways driving aberrant IAS remain poorly understood. Experimental Design: The effect of components the AKT-RUNX2-osteocalcin (OCN)–GPRC6A–CREB axis on expression steroidogenesis genes CYP11A1 CYP17A1 testosterone level were examined PTEN-null human cell lines. Pten knockout mice used...
Oral lichen planus (OLP), a T-lymphocyte-mediated disease of the oral mucosa, has complex pathogenesis that involves number factors. The is characterized by recurrent episodes and requires continuous follow up, there no curative treatment available. Erosive planus, among others, risk malignant transformation standardized to control its progression. Different clinical subtypes require appropriate treatment. Pharmacological treatments are most widely available have greatest variety options...
Research Article9 March 2018Open Access Source DataTransparent process Dual inhibition of AKT-mTOR and AR signaling by targeting HDAC3 in PTEN- or SPOP-mutated prostate cancer Yuqian Yan Department Gastroenterology, Jiangxi Institute Gastroenterology Hepatology, First Affiliated Hospital Nanchang University, Nanchang, Jiangxi, China Biochemistry Molecular Biology, Mayo Clinic College Medicine, Rochester, MN, USA Search for more papers this author Jian An Yinhui Yang Urology, The Fourth...
Despite widespread use of taxanes, mechanisms action and resistance in vivo remain to be established, there is no way predicting who will respond therapy. This study examined prostate cancer (PCa) xenografts patient samples identify taxane resistance. Docetaxel drug-target engagement was assessed by confocal anti-tubulin immunofluorescence quantify microtubule bundling interphase cells aberrant mitoses. Tumor biopsies from metastatic PCa patients obtained 2 5 days after their first dose...
Mitophagy is a conserved cellular process that plays vital role in maintaining homeostasis by selectively removing dysfunctional mitochondria. Notwithstanding growing evidence suggests mitophagy implicated pancreatic tumorigenesis, the effect of mitophagy-related genes on cancer (PC) prognosis and therapeutic response remains largely unknown. In this study, we sought to construct gene signature assessed its ability predict survival, immune activity, mutation status, chemotherapy PC patients....
Infiltration of tumor by T cells is a prerequisite for successful immunotherapy solid tumors. In this study, we investigate the influence tumor-targeted radiation on chimeric antigen receptor (CAR) T-cell therapy infiltration, accumulation, and efficacy in clinically relevant models pleural mesothelioma non-small cell lung cancers. We use nonablative dose prior to systemic administration mesothelin-targeted CAR assess proliferation, antitumor efficacy, functional persistence at primary...
ABSTRACT Helicobacter pylori infection is relatively common worldwide and closely related to gastric mucosa-associated lymphoid tissue (MALT) lymphoma, chronic gastritis, stomach ulcers. Therefore, a safe effective method for preventing H. urgently needed. Given that developing an vaccine against one of the best alternatives, adhesin Hp0410 was expressed in food-grade bacterium Lactobacillus acidophilus . The recombinant live bacterial then used orally vaccinate mice, immunoprotective...
Abstract Although differentiated thyroid carcinoma (DTC) has a good prognosis and survival rate, long-term medication recurrence monitoring might be needed. The factors that affect postoperative health-related quality of life (HRQoL) in patients with DTC different regions remain unclear or conflicting. purpose this study was to assess the influence HRQoL after surgery. This selected 174 who underwent thyroidectomy. Additionally, participants were matched by age, gender, socioeconomic status...
Cell adhesion molecule 1 (CADM1/TSLC1), a putative tumor suppressor involving in cell adhesion, proliferation and apoptosis, is frequently inactivated several carcinomas due to promoter hypermethylation. But alterations of CADM1/TSLC1 colorectal carcinogenesis clinical significance have not been elucidated yet. The aim this study was determine the role functional inactivation gene tumorigenesis its potential as novel epigenetic marker for assessment patients with cancer. We measured...
Background . Interleukin-4 (IL-4) and interleukin-6 (IL-6) have been reported to associate with pathogenesis of rheumatoid arthritis (RA); however, the role IL-4 IL-6 genetic polymorphisms in RA remains unknown. Method A total 752 unrelated Chinese patients 798 healthy volunteers no family histories any autoimmune diseases were recruited. The promoter IL-4-590 C/T IL-6-174 G/C genotyped. Result genotype distributions allele frequencies significantly different from volunteers. Statistically...
Abdominal aortic aneurysm (AAA), an irreversible cardiovascular disease prevalent in the artery, causes increase of diameter over time, and is a fatal phenomenon inducing sidewall rupture. Long noncoding RNAs (lncRNAs) serve as promising biomarkers for AAA. In present study, we sought to define role lncRNA growth-arrest-specific transcript 5 (GAS5) growth smooth muscle cells (SMC) progression AAA.Initially, established angiotensin II (Ang II)-induced AAA mouse models Ang II-treated vascular...
Abstract Background: The aims of our study were to determine the presence Helicobacter pylori DNA in dental plaque Chinese children aged 3–6 years by nested polymerase chain reaction (PCR) and investigate relationship between this infection occurrence caries or oral hygiene index. Methods: Two hundred fourteen from a kindergarten Guangzhou City China evaluated. children's plaques assessed indices Quigley–Hein. Dental was analyzed using PCR for two sets primers directed 860‐bp fragment H....
Identification of MHC class I-bound peptides by immunopurification complexes and subsequent analysis mass spectrometry is crucial for understanding T cell immunology immunotherapy. Investigation the steps ligand isolation process revealed biases in widely used techniques toward lower hydrophobicity. As hydrophobicity correlates positively with immunogenicity, identification more hydrophobic ligands could potentially lead to effective immunogenic as targets immunotherapies. We solved this...
Rationale: The Polycomb group (PcG) protein EZH2 is implicated in cancer progression due to its frequent overexpression many types and therefore a promising therapeutic target. Forkhead box transcription factor-1 (FOXO1) tumor suppressor that often transcriptionally downregulated human cancers such as prostate although the underlying regulatory mechanisms remain elusive. Methods: Analysis of ChIP-seq ChIP-on-chip data various cell was performed. ChIP-qPCR, RT-qPCR, western blot analyses were...
AIM:To express Hsp60 protein of H pylori by a constructed vector and to evaluate its immunogenicity. METHODS:Hsp60 DNA was amplified PCR inserted into the prokaryotie expression pET-22b (+), which transformed BL21 (DE3) E.coli strain recombinant protein.Immunogenicity expressed evaluated with animal experiments.RESULTS: sequence analysis showed same as GenBank's research.Hsp60 accounted for 27.2 % total bacterial protein, could be recognized serum from infected patients Balb/c mice immunized...
Abstract Background Helicobacter pylori infection is a substantial public health problem and plays etiological role in the pathogenesis of many gastroduodenal disorders. The addition ecabet sodium proven to improve efficacy standard triple therapy. Our aim was assess safety sodium–containing quadruple therapy versus 10‐day bismuth‐containing for H. eradication. Materials Methods We did randomized, open‐label, phase IV trial four cities (eight sites) China, comparing 10‐days adults with...