A5021102071- CAR-T cell therapy research
- Biosimilars and Bioanalytical Methods
- Virus-based gene therapy research
- Viral Infectious Diseases and Gene Expression in Insects
- Lung Cancer Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Cancer Research and Treatments
- Advancements in Semiconductor Devices and Circuit Design
- Peripheral Nerve Disorders
- Airway Management and Intubation Techniques
- Spinal Dysraphism and Malformations
- Immunotherapy and Immune Responses
- Reconstructive Surgery and Microvascular Techniques
- Lung Cancer Treatments and Mutations
- Nerve injury and regeneration
- Nanowire Synthesis and Applications
- Cardiac and Coronary Surgery Techniques
- Cerebrospinal fluid and hydrocephalus
- Nerve Injury and Rehabilitation
- Mesenchymal stem cell research
- Advances in Oncology and Radiotherapy
- Myasthenia Gravis and Thymoma
- Ultrasound in Clinical Applications
- Head and Neck Surgical Oncology
Memorial Sloan Kettering Cancer Center
2020-2024
Tulane Medical Center
2016-2020
Cornell University
2017
Success in solid tumor chimeric antigen receptor (CAR) T-cell therapy requires overcoming several barriers, including lung sequestration, inefficient accumulation within the tumor, and target-antigen heterogeneity. Understanding CAR kinetics can assist interpretation of response limitations thereby facilitate developing successful strategies to treat tumors. As varies across metastatic sites, assessment by peripheral blood analysis or a single-site biopsy is inadequate for response. The use...
Infiltration of tumor by T cells is a prerequisite for successful immunotherapy solid tumors. In this study, we investigate the influence tumor-targeted radiation on chimeric antigen receptor (CAR) T-cell therapy infiltration, accumulation, and efficacy in clinically relevant models pleural mesothelioma non-small cell lung cancers. We use nonablative dose prior to systemic administration mesothelin-targeted CAR assess proliferation, antitumor efficacy, functional persistence at primary...
<p>Supplementary Figures 1-13 with associated legends</p>
<p>Supplementary Figures 1-13 with associated legends</p>
<div>Abstract<p>Infiltration of tumor by T cells is a prerequisite for successful immunotherapy solid tumors. In this study, we investigate the influence tumor-targeted radiation on chimeric antigen receptor (CAR) T-cell therapy infiltration, accumulation, and efficacy in clinically relevant models pleural mesothelioma non-small cell lung cancers. We use non-ablative dose prior to systemic administration mesothelin-targeted CAR assess proliferation, anti-tumor efficacy,...
<p>Supplementary Figures 1-13 with associated legends</p>
<div>Abstract<p>Infiltration of tumor by T cells is a prerequisite for successful immunotherapy solid tumors. In this study, we investigate the influence tumor-targeted radiation on chimeric antigen receptor (CAR) T-cell therapy infiltration, accumulation, and efficacy in clinically relevant models pleural mesothelioma non-small cell lung cancers. We use non-ablative dose prior to systemic administration mesothelin-targeted CAR assess proliferation, anti-tumor efficacy,...
<p>Supplementary Figures 1-13 with associated legends</p>
<div>Abstract<p>Infiltration of tumor by T cells is a prerequisite for successful immunotherapy solid tumors. In this study, we investigate the influence tumor-targeted radiation on chimeric antigen receptor (CAR) T-cell therapy infiltration, accumulation, and efficacy in clinically relevant models pleural mesothelioma non–small cell lung cancers. We use nonablative dose prior to systemic administration mesothelin-targeted CAR assess proliferation, antitumor efficacy, functional...