A5023667267- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Lung Cancer Research Studies
- Medical Imaging and Pathology Studies
- Peptidase Inhibition and Analysis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Reproductive tract infections research
- Pleural and Pulmonary Diseases
- Ultrasound in Clinical Applications
- Cancer, Stress, Anesthesia, and Immune Response
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Bariatric Surgery and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Cells and Metastasis
- Esophageal Cancer Research and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Ovarian cancer diagnosis and treatment
- Genetic Syndromes and Imprinting
- Cardiac electrophysiology and arrhythmias
- Management of metastatic bone disease
- Cancer Mechanisms and Therapy
- Glaucoma and retinal disorders
- Parathyroid Disorders and Treatments
Twitter (United States)
2025
Cleveland Clinic
2025
Memorial Sloan Kettering Cancer Center
2018-2023
Royal Berkshire Hospital
2019-2021
Regional Medical Center
2021
Cornell University
2018-2020
New York Hospital Queens
2018-2020
Presbyterian Hospital
2018-2020
NewYork–Presbyterian Hospital
2018-2020
Edinburgh Cancer Research
2015
Recommendations for adjuvant therapy after surgical resection of lung adenocarcinoma (LUAD) are based solely on TNM classification but agnostic to genomic and high-risk clinicopathologic factors. Creation a prediction model that integrates tumor factors may better identify patients at risk recurrence.
The thyrotrophin receptor (TSHR) provides an autoantigenic link between the thyroid and orbit in Graves' (GD) eye diseases (TED). We measured TSHR transcripts different fat depots to determine whether expression levels are influenced by autoimmune/inflammatory process and/or hormone status, using quantitative real-time PCR. Nine intact or fractionated adipose samples, from patients with GD TED, were analysed ex vivo. Eight expressed TSHR, at approaching thyroid, one was limit of detection....
Abstract Purpose: KRAS G12C is the most common mutation in primary lung adenocarcinoma. Phase I clinical trials have demonstrated encouraging activity of KRASG12C inhibitors metastatic setting. We investigated disease-free survival (DFS) and tumor genomic features patients with surgically resected KRASG12C-mutant Experimental Design: Patients who underwent resection stage I–III adenocarcinoma next-generation sequencing (NGS) were evaluated. Exclusion criteria receipt induction therapy,...
The majority of broad-panel tumor genomic profiling has used a gene-centric approach, although much that data is unused in clinical decision making. We hypothesized pathway-centric approach using next-generation sequencing (NGS), combined with conventional clinicopathologic features, may better predict disease-free survival (DFS) early stage lung adenocarcinoma.Utilizing our prospectively maintained database, we analyzed 492 patients primary, untreated, completely surgically resected...
Left ventricular (LV) remodeling has been attributed to the segmental loss of viable myocardium due myocardial infarction (MI), which results in redistribution cardiac workload, with increased regional wall stress and around infarct zone. Because pacing shown reduce workload regions near site, this trial was designed test whether chronic attenuates LV remodeling.Eighty patients an anterior MI, peak creatine kinase >2000 mU/mL, ejection fraction ≤35%, motion abnormality (WMA) >5 16 segments,...
Abstract While next-generation sequencing (NGS) is used to guide therapy in patients with metastatic lung adenocarcinoma (LUAD), use of NGS determine pathologic LN metastasis prior surgery has not been assessed. To bridge this knowledge gap, we performed using MSK-IMPACT 426 treatment-naive clinical N2-negative LUAD. A multivariable logistic regression model that considered preoperative and genomic variables was constructed. Most had cN0 disease (85%) pN0, pN1, pN2 rates 80%, 11%, 9%,...
About 50% of patients with early-stage, surgically resected lung cancer will develop distant metastasis. There remains an unmet need to identify likely recurrence and design innovative therapies decrease this risk. Two primary isoforms BRMS1, v1 v2, are present in humans. Using next-generation sequencing BRMS1 on matched human noncancerous tissue non–small cell (NSCLC) specimens, we identified single-nucleotide polymorphism (SNP) rs1052566 that results A273V mutation BRMS1v2. This SNP is...
Stage IV non-small cell lung cancer (NSCLC) accounts for 35 to 40% of newly diagnosed cases NSCLC. The oligometastatic state—≤5 extrathoracic metastatic lesions in ≤3 organs—is present ~25% patients with stage disease and is associated markedly improved outcomes. We retrospectively identified NSCLC who underwent primary tumor resection at our institution from 2000 2018. Event-free survival (EFS) overall (OS) were estimated using the Kaplan–Meier method. Factors EFS OS determined Cox...
Locally advanced non-small-cell lung cancer (NSCLC) with chest wall invasion carries a high risk of recurrence and portends poor survival (30-40% 20-50%, respectively). No studies have identified prognostic factors in patients who underwent R0 resection for non-superior sulcus NSCLC.A retrospective review was conducted all resections NSCLC from 2004 to 2018. Patients superior tumours, partial (<1 rib) or incomplete (R1/R2) distant metastasis were excluded. Disease-free (DFS) overall (OS)...
Objective: We examined management strategies, overall survival (OS), and progression-free (PFS) among patients with PMNSGCTs undergoing resection multidisciplinary at a high-volume institution. Summary of Background Data: Outcomes after are not well-characterized, limited data on factors associated survival. Methods: reviewed PMNSGCT who underwent between 1980 2019. Median follow-up was 3.4 years. Preoperative therapy (including use bleomycin), surgical management, recurrence, were examined....
Predicting perioperative morbidity and mortality can be achieved by several risk predicting algorithms. In the UK, National Emergency Laparotomy Audit, mandated for all patients undergoing emergency laparotomy, uses pPOSSUM as its prediction tool. However, there is no literature reporting inter-operator variability in calculating score. Inter-rater was assessed based on 10 real general surgical cases that went to have an laparotomy.Forty clinicians, each of registrars consultants...
Objective: We sought to quantify and characterize long-term consequences of pneumonectomy, with particular attention nononcologic mortality. Summary Background Data: Pneumonectomy is associated profound changes in cardiopulmonary physiology. Studies outcomes after pneumonectomy typically report generalized measures, such as disease-free overall survival. Methods: Patients undergoing lobectomy or for lung cancer at our institution from 2000 2018 were reviewed. Propensity-score matching was...