A5035201433- Breast Cancer Treatment Studies
- Oral microbiology and periodontitis research
- Gut microbiota and health
- Endoplasmic Reticulum Stress and Disease
- Advanced Breast Cancer Therapies
- Autophagy in Disease and Therapy
- HER2/EGFR in Cancer Research
- Breast Lesions and Carcinomas
- Optical Network Technologies
- Cancer Cells and Metastasis
- Bacterial biofilms and quorum sensing
- PI3K/AKT/mTOR signaling in cancer
- Thermochemical Biomass Conversion Processes
- Antibiotic Resistance in Bacteria
- Cancer-related Molecular Pathways
- Cancer Treatment and Pharmacology
- Histone Deacetylase Inhibitors Research
- Advanced Photonic Communication Systems
- RNA modifications and cancer
- Salivary Gland Disorders and Functions
- Ferroptosis and cancer prognosis
- Radiomics and Machine Learning in Medical Imaging
- Intensive Care Unit Cognitive Disorders
- Bacteriophages and microbial interactions
- AI in cancer detection
Xuzhou Medical College
2024-2025
Sichuan University
2014-2025
University of California, San Diego
2024-2025
First Affiliated Hospital of Nanchang University
2025
Nanchang University
2014-2025
Human Longevity (United States)
2025
Université Bourgogne Franche-Comté
2025
Dongfeng Motor (China)
2023-2024
Research & Development Institute
2024
Shandong Academy of Sciences
2022-2024
Among breast cancers without human epidermal growth factor receptor 2 (HER2) amplification, overexpression, or both, a large proportion express low levels of HER2 that may be targetable. Currently available HER2-directed therapies have been ineffective in patients with these "HER2-low" cancers.
Hypervirulent Klebsiella pneumoniae (hvKp) is a concerning pathogen that can cause life-threatening infections in otherwise healthy individuals. Importantly, although strains of hvKp have been acquiring antimicrobial resistance, the effect on virulence unclear. Therefore, it critical importance to determine whether given resistant K. isolate hypervirulent. This report determined which combination genotypic and phenotypic markers could most accurately identify with acquired resistance. Both...
Abstract Introduction Paclitaxel (Taxol ® ) is a microtubule-targeted agent that widely used for cancer treatment. However, resistance to paclitaxel frequently encountered in the clinic. There increasing interest identifying compounds may increase sensitivity conventional chemotherapeutic agents. In this study, we investigated whether green tea polyphenol (-)-epigallocatechin gallate (EGCG) could sensitize breast carcinoma vivo . Methods Breast cells were treated with or without EGCG and...
Abstract Background The global BOLERO-2 trial established the efficacy and safety of combination everolimus (EVE) exemestane (EXE) in treatment estrogen receptor positive (ER +), HER2-, advanced breast cancer (ABC). BOLERO-5 investigated this a Chinese population (NCT03312738). Methods is randomized, double-blind, multicenter, placebo controlled, phase II comparing EVE (10 mg/day) or (PBO) with EXE (25 mg/day). primary endpoint was progression-free survival (PFS) per investigator assessment....
<title>Abstract</title> Allopolyploidy involves the fusion of genomes from different lineages through hybridization and chromosome doubling. However, detecting early allopolyploidy events in evolutionary history understanding specific subgenomic evolution that contributes to origin adaptive innovations for species radiation can be challenging. Here, we sequenced representing all three subfamilies Salicaceae, a woody model clade, collected epigenetic transcriptomic samples. We revealed one...
Given the potential relationship between head and neck squamous cell carcinoma (HNSCC) microbial dysbiosis, we profiled microbiome within healthy normal tumorous (primary metastatic) human tissues from oral cavity, larynx-pharynx, lymph nodes using 16S rRNA sequencing. Alpha beta diversity analyses revealed that had greatest richness in community diversity, while metastatic populations were most closely related to one another. Compared normal, microbiota associated with tumors supported...
Increasing evidence highlights the cardinal role of gut microbiota in tumorigenesis and chemotherapy outcomes. Paclitaxel (PTX), although as a first-line reagent for breast cancer, still requires improvement on its efficacy safety due to drug resistance adverse effects. The present work explored enhancement polysaccharide derived from spore Ganoderma lucidum (SGP) with PTX murine 4T1-breast cancer model. Results showed that combination SGP displayed an improved tumor control, which mRNA...
Taxane and vinblastine represent two classes of microtubules-targeted agents for cancer chemotherapy. Although taxol are widely used treatment, resistance to these is frequently encountered in the clinic. An ongoing question has been what mechanisms involved tumour cells or how clinical effectiveness can be improved. There increasing evidence that microtubules interact with endoplasmic reticulum (ER). Here, we have shown induce multiple arms ER stress response, including up-regulation...
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is an inducer of cancer cell death that holds promise in therapy. Cancer cells are more susceptible than normal to the cell-death-inducing effects TRAIL. However, a variety resistant TRAIL through complex mechanisms. Here, we investigate inhibition eukaryotic initiation factor 2 subunit α (eIF2α) dephosphorylation on TRAIL-induced apoptosis hepatoma cells. Treatment with salubrinal, inhibitor eIF2α dephosphorylation, enhances...
Source-separated human urine was collected from six public events to study the impact of processing and storage on bacterial community composition viability. Illumina 16S rRNA gene sequencing revealed a complex bacteria in fresh that differed across collection events. Despite harsh chemical conditions stored (pH > 9 total ammonia nitrogen 4000 mg N/L), consistently grew 5 ± 2 × 108 cells/mL. Storing hydrolyzed for any amount time significantly reduced number operational taxonomic units...
Side effects of chemotherapy are burning questions for physicians and patients involved in cancers. Ganoderma lucidum is a widely consumed traditional Chinese medicine edible mushroom with multiple functional properties. The present study aims to investigate the potential polysaccharides from spore G. (SGP) on small intestinal barrier function recovery against paclitaxel (PTX) challenge breast cancer mice model IEC-6 cell line. 4T1 tumor-bearing were treated PTX together four-week daily oral...