A5100444951- Supply Chain and Inventory Management
- Tryptophan and brain disorders
- Gut microbiota and health
- Corporate Finance and Governance
- Stress Responses and Cortisol
- Insect Resistance and Genetics
- Insect symbiosis and bacterial influences
- Genomics and Phylogenetic Studies
- Epigenetics and DNA Methylation
- Endoplasmic Reticulum Stress and Disease
- Metabolomics and Mass Spectrometry Studies
- Scheduling and Optimization Algorithms
- Lung Cancer Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Adipose Tissue and Metabolism
- Insect-Plant Interactions and Control
- Consumer Market Behavior and Pricing
- Diet and metabolism studies
- Cancer Genomics and Diagnostics
- Auction Theory and Applications
- Genetic Syndromes and Imprinting
- Working Capital and Financial Performance
- MicroRNA in disease regulation
- Artificial Intelligence in Healthcare and Education
- Cancer survivorship and care
Sichuan University
2008-2025
Southern Medical University
2025
Nanfang Hospital
2025
Army Medical University
2025
Southwest Hospital
2025
Inner Mongolia University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2023
Guangzhou College of Commerce
2023
Institut de Biologia Evolutiva
2023
Universitat Pompeu Fabra
2023
The operations‐finance interface (OFI) jointly optimizes material, monetary, and information flows under intricate sources of uncertainty. To sketch the broad landscape in this emerging interdisciplinary field, study synthesizes literature across diverse themes dispersed methodologies, screens systematically research progression from original foundations to recent contributions each major stream, thereby advocates future innovations on prospective topics light interconnections potential...
Taxane and vinblastine represent two classes of microtubules-targeted agents for cancer chemotherapy. Although taxol are widely used treatment, resistance to these is frequently encountered in the clinic. An ongoing question has been what mechanisms involved tumour cells or how clinical effectiveness can be improved. There increasing evidence that microtubules interact with endoplasmic reticulum (ER). Here, we have shown induce multiple arms ER stress response, including up-regulation...
Abstract With the progression of modern information techniques, such as next generation sequencing (NGS), Internet Everything (IoE) based smart sensors, and artificial intelligence algorithms, data-intensive research applications are emerging fourth paradigm for scientific discovery. However, we face many challenges to practical application this paradigm. In article, 10 discovery in precision medicine healthcare summarized future perspectives on discussed.
Abstract Introduction Aberrant microenvironment and endoplasmic reticulum (ER) stress are associated with solid-tumor progression. Stress proteins, like heat shock proteins glucose-regulated frequently overexpressed in human tumors. It has been reported that derlin-1 is involved ER response. In vitro studies have demonstrated participates the retrotranslocation of misfolded from into cytosol. Because roles cancer not yet characterized, we investigated expression breast carcinoma whether it...
Spodoptera litura is an important polyphagous pest that causes significant damage to the agricultural sector. We performed RNA-seq of 15 S. individuals from larval (fifth and sixth instar larvae), chrysalis, adult developmental stages. also compared transcriptome data with frugiperda across same stages, which was sequenced in our previous study.A total 101,885 differentially expressed transcripts (DETs) were identified litura. Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG)...
Background Patients with microsatellite stable (MSS) colorectal cancer (CRC) often display resistance to immunotherapy. Epidermal growth factor receptor (EGFR)-targeted therapies have shown potential in enhancing immunotherapy, yet clinical benefits remain unfulfilled, which may relate inadequate patient stratification. Methods Circulating tumor cells and tissues were collected from multicenter cohorts of patients CRC receiving cetuximab analyze EGFR variant type III (EGFRvIII) expression...
It is an important measure in the reform of state-owned enterprises to improve efficiency capital operation by introducing non-state-owned shareholders. This paper explores impact non-state shareholder governance on structure decision-making using data 2008–2021 A-share listed companies from perspective speed and deviation adjustment. The results reveal that only shareholding has no significant adjustment a company. However, appointment senior management shareholders can up lower degree...
Pikas (Lagomorpha: Ochotonidae) are small mouse-like lagomorphs. To investigate their adaptation to different ecological environments during dispersal from the Qinghai-Xizang (Tibet) Plateau (QTP), we collected 226 pikas and measured 20 morphological characteristics recorded habitat information. We also sequenced genome of 81 specimens, representing 27 putative pika species. The genome-wide tree based on 4 090 coding genes identified five subgenera, i.e., Alienauroa, Conothoa, Lagotona,...
Macaques (genus
Previous studies have demonstrated that gamma-synuclein is overexpressed in a variety of human malignancies. Overexpression breast cancer cells leads to an increase cell motility, resistance chemotherapeutic drugs, and mitotic checkpoint dysfunction. We report this study up-regulated by endoplasmic reticulum stress. The up-regulation expression stress mediated, at least part, activation transcription factor (ATF) 4. Knockdown sensitized stress-induced apoptosis. Induction apoptosis when was...
Vitamin D (VD) was reported to play protective roles in skeletal muscle. This study aimed explore whether endoplasmic reticulum (ER) stress inhibition is associated with the effects of VD/VD receptor (VDR) signaling on muscle functions. C2C12 cells were treated palmitic acid (PA) and then incubated different concentrations 1,25-(OH)2-vitamin D3 (VD3), we found that VD3 improved impaired cell viability induced by PA increased VDR expression a dose-dependent manner. Then 100 nM treatment...
Aging is a complex multifactorial process that greatly affects animal health. Multi-omics analysis widely applied in evolutionary biology and biomedical research. However, whether multi-omics can provide sufficient information to reveal comprehensive changes aged non-human primates remains unclear. Here, we explored host-microbe interactions with aging Chinese rhesus macaques (
Background Up the reproductive tract, there are large differences in composition of vaginal microbes. Throughout menstrual cycle, structure microbiome shifts. Few studies have examined both combination. Our study was designed to explore trends different parts vagina healthy women over cycle. Methods We performed metagenomic sequencing characterize between cervical orifice and mid-vagina throughout Results results showed similar during periovulatory luteal phases, with Lactobacillus being...
As the world recovers from COVID-19 pandemic, a resurgence in MPXV cases is causing serious concern. The early clinical similarity of to common ailments like flu and cold, coupled with resemblances its progressing rash other infections, underscores importance prompt accurate diagnosis. Among smallpox clinically closest MPXV, rashes similar stages also appear syphilis varicella zoster. A comprehensive review herpes, was carried out, including structural morphological features, origins,...
Background: To investigate the effectiveness and cost minimization of comprehensive pulmonary rehabilitation (CPR) in lung cancer patients who underwent surgery. Patients Methods: A retrospective observational study based on medical records was conducted, with 2410 an operation with/without CPR during peri-operative period. Variables including clinical characteristics, length stay (LOS), postoperative complications (PPCs), hospitalization expenses were compared between intervention group...
Patients with pulmonary nodules are treated by minimally invasive surgery, and postoperative symptoms have become the main factors affecting patients' emotion quality of life. This study aimed to analyze changes in lung cancer patients nodules.The clinical data eighty-eight admitted same medical group Department Thoracic Surgery, West China Hospital Sichuan University from June 2021 September were prospectively collected analyzed. The types severity before operation, on discharge day, 30-day...
Introduction Lung cancer remains a highly fatal disease. Surgical resection has been proven to be the most effective treatment for early-stage lung cancer. The conventional hospital-based pulmonary rehabilitation (PR) is shown reduce symptoms, improve exercise capacity and impact quality of life (QoL) patients. To date, scientific evidence on effectiveness home-based PR patients with following surgery scarce. We aim explore if non-inferior outpatient surgical resection. Methods analysis This...
Summary The Tibetan chicken is a native Chinese breed that lives at high elevations and has adapted to the extreme environmental conditions of Plateau. However, its hypoxic adaptation gene expression level unclear. Here, we sequenced nine lung transcriptomes three developmental stages (5 42 weeks 4.5 years). A total 1.02 billion clean reads were obtained. We identified 16 012 mRNAs 6898 lncRNAs. mRNA showed samples significantly divided into clusters, with higher correlation closer...