A5037475370- Advanced Fluorescence Microscopy Techniques
- Bioinformatics and Genomic Networks
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Advanced Electron Microscopy Techniques and Applications
- Advanced Biosensing Techniques and Applications
- Molecular Sensors and Ion Detection
- Biomedical Text Mining and Ontologies
- Monoclonal and Polyclonal Antibodies Research
- Osteoarthritis Treatment and Mechanisms
- MicroRNA in disease regulation
- Cardiovascular Function and Risk Factors
- Cancer Cells and Metastasis
- Nanoplatforms for cancer theranostics
- Cancer-related molecular mechanisms research
- Gene expression and cancer classification
- Circular RNAs in diseases
- Supramolecular Self-Assembly in Materials
- Cell Image Analysis Techniques
- Delphi Technique in Research
- Adaptive optics and wavefront sensing
- Machine Learning in Bioinformatics
- Mobile Health and mHealth Applications
- Physical Activity and Health
- Heart Failure Treatment and Management
Sichuan University
2014-2025
Purdue University West Lafayette
2019-2024
Quest Diagnostics (United States)
2023-2024
Center for Excellence in Molecular Cell Science
2023
Chinese Academy of Sciences
2023
Soochow University
2019-2021
Qingdao University of Science and Technology
2019-2021
Hunan University
2019-2020
State Key Laboratory of Chemobiosensing and Chemometrics
2019
New Jersey Institute of Technology
2018
The development of a theragnostic platform integrating precise diagnosis and effective treatment is significant but still extremely challenging. Herein, an integrated smart nanodevice composed Au@Cu2–xS@polydopamine nanoparticles (ACSPs) fuel DNA-conjugated tetrahedral DNA nanostructures (fTDNs) was constructed, in which the ACSP nanoprobe played multiple key roles antitumor therapy as well situ monitoring microRNAs (miRNAs) cancer cells. Regarding analysis, probe contained two optical...
Abstract In order to maintain tissue homeostasis, cells communicate with the outside environment by receiving molecular signals, transmitting them, and responding accordingly signaling pathways. Thus, one key challenge in engineering systems involves design construction of different modules into a rationally integrated system that mimics cascade events. Herein, we DNA-based artificial uses confined microenvironment giant vesicle, derived from living cell. This consists two main components....
Cell–cell communication plays a vital role in biological activities; particular, membrane–protein interactions are profoundly significant. In order to explore the underlying mechanism of intercellular signaling pathways, full range artificial systems have been explored. However, many them complicated and uncontrollable. Herein we designed an signal transduction system able control influx environmental ions by triggering activation synthetic transmembrane channels immobilized on giant...
Objectives Stretch affects vascular smooth muscle cell proliferation and apoptosis, several responsible genes have been proposed. We tested whether the expression of microRNA 21 (miR-21) is modulated by stretch involved in stretch-induced apoptosis human aortic cells (HASMCs). Methods Results RT-PCR revealed that elevated (16% elongation, 1 Hz) increased miR-21 cultured HASMCs, moderate (10% decreased expression. BrdU incorporation assay counting showed HASMCs mediated stretch, likely...
Abstract The inhomogeneous refractive indices of biological tissues blur and distort single-molecule emission patterns generating image artifacts decreasing the achievable resolution localization microscopy (SMLM). Conventional sensorless adaptive optics methods rely on iterative mirror changes image-quality metrics. However, these metrics result in inconsistent metric responses thus fundamentally limit their efficacy for aberration correction tissues. To bypass trial-then-evaluate...
Objective Dickkopf-1 (DKK-1), a major regulator of the Wnt pathway, plays an important role in cardiovascular disease. However, no study has evaluated association DKK-1 and acute coronary syndrome (ACS). We investigated this whether Global Registry Acute Coronary Events (GRACE) hospital-discharge risk score predicting adverse cardiac events (MACE) can be improved by adding value. Methods enrolled 291 patients (46 with ST-segment elevation myocardial infarction [STEMI] 245 non-ST elevated ACS...
Single-particle tracking (SPT) provides high-resolution spatial-temporal information on biomolecule dynamics. However, localization inaccuracies, limited track lengths, heterogeneous fluorescence backgrounds, and potential molecular motion blur pose significant challenges that hinder the accurate extraction of movement trajectories their underlying behavior. The conventional SPT pipeline struggles to comprehensively address detection, localization, linkage, parameter inference...
Abstract INTRODUCTION Neurodegenerative diseases (NDDs) are chronic caused by brain neuron degeneration, requiring systematic integration of risk factors to address their heterogeneity. Established in 2021, Knowledgebase Risk Factors for Diseases (NDDRF) was the first knowledge base consolidate NDD factors. NDDRF 2.0 expands focus modifiable lifestyle‐related factors, enhancing utility prevention. METHODS Data from past 4 years were comprehensively updated, while lifestyle manually collected...
Biomimetic giant membrane vesicles, with size and lipid compositions comparable to cells, have been recognized as an attractive experimental alternative living systems. Due the similarity of their structure that body cell-derived plasma vesicles used a model for studying lipid/protein behavior membranes. However, further application biomimetic has hampered by side-effects chemical vesiculants utilization osmotic buffer. We herein develop facile strategy derive (GMVs) from mammalian cells in...
Abstract: Neurodegenerative diseases represent a prevalent category of age-associated diseases. As human lifespans extend and societies become increasingly aged, neurodegenerative pose growing threat to public health. The lack effective therapeutic drugs for both common rare amplifies the medical challenges they present. Current treatments these primarily offer symptomatic relief rather than cure, underscoring pressing need develop efficacious interventions. Drug repositioning, an innovative...
Doxorubicin (Dox) micelles showed improved anti-metastasis activity by killing circulating tumor cells (CTCs) in zebrafish and mouse models, which may have potential applications cancer therapy.
Heart failure (HF) is a cardiovascular disease with high incidence around the world. Accumulating studies have focused on identification of biomarkers for HF precision medicine. To understand heterogeneity and provide biomarker information personalized diagnosis treatment HF, knowledge database collecting distributed multiple-level necessary.In this study, (HFBD) was established by manually data from literature in PubMed. HFBD contains 2618 records 868 (731 single 137 combined) extracted...
Fluorescence nanoscopy has become an indispensable tool for studying organelle structures, protein dynamics, and interactions in biological sciences. Single-molecule localization microscopy can now routinely achieve 10–50 nm resolution through fluorescently labeled specimens lateral optical sections. However, visualizing structures organized along the axial direction demands scanning imaging each of planes with fine intervals throughout whole cell. This iterative process suffers from...
ABSTRACT RNA helicase DDX5 is a host restriction factor for hepatitis B virus (HBV) biosynthesis. Mass spectrometry (LC‐MS/MS) identified significant DDX5‐interacting partners, including interferon‐inducible protein 16 (IFI16) and RBBP4/7, an auxiliary subunit of polycomb repressive complex 2 (PRC2). co‐eluted with IFI16, core PRC2 subunits in size exclusion chromatography fractions derived from native nuclear extracts. Native gel electrophoresis immunoprecipitants revealed 750 kDa...
Abstract Postoperative pulmonary complications (PPCs) are highly heterogeneous disorders with diverse risk factors frequently occurring after surgical interventions, resulting in significant financial burdens, prolonged hospitalization and elevated mortality rates. Despite the existence of multiple studies on PPCs, a comprehensive knowledge base that can effectively integrate visualize associated PPCs is currently lacking. This study aims to develop an online platform for (Postoperative...