A5100624808- RNA Research and Splicing
- Galectins and Cancer Biology
- Cancer-related molecular mechanisms research
- RNA regulation and disease
- Bioactive Natural Diterpenoids Research
- Macrophage Migration Inhibitory Factor
- Glycosylation and Glycoproteins Research
- Cryptography and Data Security
- Liver Disease Diagnosis and Treatment
- Nutritional Studies and Diet
- Privacy-Preserving Technologies in Data
- Plant-based Medicinal Research
- Obesity, Physical Activity, Diet
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Synthetic Organic Chemistry Methods
- Peptidase Inhibition and Analysis
- Gut microbiota and health
- Network Security and Intrusion Detection
- Advanced Malware Detection Techniques
- Cancer-related Molecular Pathways
- PI3K/AKT/mTOR signaling in cancer
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal motility and disorders
- Metabolomics and Mass Spectrometry Studies
- Microbial Natural Products and Biosynthesis
Shuguang Hospital
2023-2025
Shanghai University of Traditional Chinese Medicine
2023-2025
Shandong Provincial QianFoShan Hospital
2025
Shandong First Medical University
2024-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2025
Huaqiao University
2024
Zhengzhou University
2016-2024
Capital Medical University
2014-2024
Northwest University
2024
Palacký University Olomouc
2024
Abstract Constitutive activation of RAS-RAF-MEK-ERK signaling pathway (MAPK pathway) frequently occurs in many cancers harboring RAS or RAF oncogenic mutations. Because the paradoxical induced by a single use BRAF MEK inhibitors, dual-target and treatment is thought to be promising strategy. In this work, we evaluated erianin novel inhibitor CRAF MEK1/2 kinases, thus suppressing constitutive MAPK V600E KinaseProfiler enzyme profiling, surface plasmon resonance (SPR), isothermal titration...
Abstract Esophageal squamous precancerous lesions (ESPL) are the precursors of esophageal cell carcinoma (ESCC) including low-grade and high-grade intraepithelial neoplasia. Due to absence molecular indicators, which ESPL will eventually develop into ESCC thus should be treated is not well defined. Indicators, for predicting risks at stages, an urgent need. We perform spatial whole-transcriptome atlas analysis, can eliminate other tissue interference by sequencing specific regions. In this...
Abstract Overexpression or activation of AKT is very well known to control cell growth, survival, and gene expression in solid tumors. Oridonin, an inflammatory medical diterpenoid compound isolated from Rabdosia rubescens, has exhibited various pharmacologic physiologic properties, including antitumor, antibacterial, anti-inflammatory effects. In this study, we demonstrated that oridonin inhibitor suppresses proliferation esophageal squamous carcinoma (ESCC) vitro vivo. The role ESCC was...
Abstract Objective: Limited information is available on the direct effect of menopause and risk type 2 diabetes mellitus (T2DM) among women with different metabolic types. We aimed to investigate whether a factor for T2DM. Methods: In this population-based cross-sectional study, were recruited from rural area China July August 2013 2014. Multivariate logistic regression analysis yielded adjusted odds ratios (ORs) 95% CIs. Mediation was performed examine contribution age status-related...
Esophageal cancer, a leading cause of cancer death worldwide, is associated with abnormal activation the AKT signaling pathway. Xanthohumol, prenylated flavonoid tested in clinical trials, reported to exert anti-diabetes, anti-inflammation and anticancer activities. However, mechanisms underlying its chemopreventive or chemotherapeutic effects remain elusive. In present study, we found that xanthohumol directly targeted AKT1/2 esophageal squamous cell carcinoma (ESCC). Xanthohumol...
For the first time, electrochemiluminescence (ECL) emission was observed from black phosphorus quantum dots (BPQDs) in presence of K2S2O8 as co-reactant. The potential application BPQDs ECL analytical chemistry also demonstrated using Cu2+ an example.
The neural EGF-like 1 (NELL-1) protein is a novel antigen in primary membranous nephropathy. prevalence and clinical characteristics of NELL-1-positive nephropathy Chinese individuals with are unclear.A total 832 consecutive patients biopsy-proven were enrolled. glomerular expression phospholipase A2 receptor (PLA2R) thrombospondin type domain-containing 7A (THSD7A) was screened. Glomerular immunohistochemistry staining for NELL-1 performed 43 PLA2R- THSD7A-negative nephropathy, 31...
Chronic migraine is a common and highly disabling disorder. Functional MRI has indicated that abnormal brain region activation linked with chronic migraine. Drugs targeting the calcitonin gene-related peptide (CGRP) or its receptor have been reported to be efficient for treating The CGRP signaling was also shared in two types of models (CMMs). However, it remains unclear whether specific regions could contribute persistent behavioral sensitization, antagonists relieve migraine-like pain CMMs...
Diabetic nephropathy (DN) is the leading cause of chronic kidney failure and end-stage disease. More accurate non-invasive test for diagnosis monitoring progression DN urgently needed better care such patients. In this study we utilized urinary glycoproteome to discover differential proteins during course type 2 DN. The glycoproteins from normal controls, normalbuminuira, microalbuminura, macroalbuminuria patients were enriched by concanavalin A (ConA) analyzed 2DLC/MS/MS isobaric tags...
Abstract Hyperuricemia contributes to chronic kidney disease development. However, it has been historically viewed with limited research interest. In this study, we mimicked the development of hyperuricemic nephropathy by using a potassium oxonate‐induced hyperuricemia rat model. We found that administering vitamin C at 10 mg/kg/day effectively ameliorated nephropathy. Compared control group, rats had significantly increased serum uric acid level, xanthine oxidase activity, and urine...
BACKGROUND Three-dimensional organoid culture systems have been established as a robust tool for elucidating mechanisms and performing drug efficacy testing. The use of gastric models holds significant promise advancing personalized medicine research. However, comprehensive bibliometric review this bur-geoning field has not yet published. AIM To analyze understand the development, impact, direction research using methods data from Web Science Core Collection (WoSCC) database. METHODS This...
Access control is one of the most important security mechanisms in cloud computing. Attributed based encryption provides an approach that allows data owners to integrate access policies within encrypted data. However, little work has been done explore flexible authorization specifying user's privileges and enforcing owner's policy environments. In this paper, we propose a hierarchical attribute scheme by extending ciphertext-policy attribute-based (CP-ABE) with structure multiauthorities...
In the fog computing environment, encrypted sensitive data may be transferred to multiple nodes on edge of a network for low latency; thus, need implement search over as cloud server. Since tend provide service IoT applications often running resource-constrained end devices, it is necessary design lightweight solutions. At present, there little research this issue. paper, we propose fine-grained owner-forced and access authorization scheme spanning user-fog-cloud resource constrained users....