A5100401009- Cancer-related molecular mechanisms research
- Bioinformatics and Genomic Networks
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Computational Drug Discovery Methods
- Epigenetics and DNA Methylation
- Sexual Differentiation and Disorders
- Planarian Biology and Electrostimulation
- RNA modifications and cancer
- Gene expression and cancer classification
- Genomics and Chromatin Dynamics
- Cancer-related gene regulation
- Ferroptosis and cancer prognosis
- Mycorrhizal Fungi and Plant Interactions
- Molecular Biology Techniques and Applications
- RNA Research and Splicing
- Genomics and Phylogenetic Studies
- Plant Stress Responses and Tolerance
- Protein Structure and Dynamics
- Heavy metals in environment
- Plant Pathogens and Fungal Diseases
- Biofuel production and bioconversion
- Extracellular vesicles in disease
- Prostate Cancer Treatment and Research
- Catalysis for Biomass Conversion
Xiamen University
2024-2025
First Affiliated Hospital Zhejiang University
2017-2025
Jiangsu University
2025
Suzhou University of Science and Technology
2016-2025
China Medical University
2016-2025
Mayo Clinic in Arizona
2020-2025
East China University of Science and Technology
2025
Wenzhou Medical University
2024
Beijing Children’s Hospital
2011-2024
Affiliated Hospital of Guangdong Medical College Hospital
2024
The advent of next-generation sequencing technologies is accompanied with the development many whole-genome sequence assembly methods and software, especially for de novo fragment assembly. Due to poor knowledge about applicability performance these software tools, choosing a befitting assembler becomes tough task. Here, we provide information adaptivity each program, then above all, compare eight distinct tools against groups simulated datasets from Solexa platform. Considering...
Abstract Metastasis is the leading cause of high mortality in colorectal cancer (CRC), which not only driven by changes occurring within tumor cells, but also influenced dynamic interaction between cells and components microenvironment (TME). Currently, exploration TME remodeling its impact on CRC metastasis has attracted increasing attention owing to potential uncover novel therapeutic avenues. Noteworthy, emerging studies suggested that tumor-associated macrophages (TAMs) played important...
Abstract Tumor-associated macrophages are increasingly viewed as a target of great relevance in the tumor microenvironment, because their important role cancer progression and metastasis. However, endogenous regulatory mechanisms underlying tumor-associated macrophage differentiation remain largely unknown. Here, we report that caspase-1 promotes by cleaving peroxisome proliferator-activated receptor gamma (PPARγ) at Asp64, thus generating 41 kDa fragment. This truncated PPARγ translocates...
PPARγ has emerged as a master regulator of macrophage polarization and is the molecular target thiazolidinedione drugs. Here we show that apigenin binds activates by acting modulator. Activation blocks p65 translocation into nuclei through inhibition p65/PPARγ complex nuclei, thereby decreasing NF-κB activation favoringM2 polarization. In HFD ob/ob mice, significantly reverses M1 M2 reduces infiltration inflammatory cells in liver adipose tissues, well decreases levels pro-inflammatory...
Two new species of flatworm, collected from a beach at eastern Shenzhen, China, were studied through an integrative approach by combining morphological, histological, histochemical (acetylcholinesterase, AChE), and molecular (18S r- DNA) data. These belong to two genera marine triclads, previously unrecorded viz. Nerpa Marcus, 1948 Paucumara Sluys, 1989. fistulata Wang & Chen, sp. nov. is characterized by: transparent body; principally pentamerous intestine with three distinct...
Wood-rotting basidiomycetes have been investigated in the Chinese forest ecosystem for past 30 years. Two hundred and five pathogenic wood-decayers belonging to 9 orders, families, 74 genera found native forests, plantations, gardens. Seventy-two species (accounting 35% of total species) are reported as fungi China first time. Among these pathogens, 184 polypores, nine corticioid fungi, eight agarics hydnoid basidiomycetes. One seventy-seven 86%) cause white rot, while 28 14%) result brown...
To achieve high ionic liquid (IL) tolerance and promote in situ enzymatic hydrolysis of biomass, four metal–organic framework (MOF) carriers, including ZIF-8, UIO-66-NH2, MIL-100-Fe, PCN-250, were used for cellulase immobilization through simple physical adsorption. The results showed that ZIF-8 had the largest enzyme adsorption capacity at 176.16 mg/g support. In addition, immobilized cellulases activity was evaluated presence 1-ethyl-3-methylimidazolium diethylphosphate ([Emim]DEP) by...
Prostate cancer (PCa) is a leading cause of cancer-related death men worldwide. There an urgent need to develop novel biomarkers for PCa prognosis and diagnosis in the post prostate specific antigen era. Long intergenic noncoding RNAs (lincRNAs) play essential roles many physiological processes can serve as alternative cancer, but there has been no systematic investigation lincRNAs yet. Nine lincRNA co-expression modules were identified from RNA-Seq data. The association between principle...
Clear cell renal carcinoma (ccRCC) is one of the most aggressive urological malignancies. MicroRNAs (miRNAs) are post-transcriptional gene regulators in tumor pathophysiology. As miRNAs exert cooperative repressive effects on target genes, studying miRNA synergism important to elucidate regulation mechanism miRNAs.We first created a miRNA-mRNA association network based sequence complementarity and co-expression patterns miRNA-targets. The between was then defined their expressional coherence...
// Wenying Yan 1, 2, 3 , Lihua Xu 4, 5 Zhandong Sun 1 Yuxin Lin Wenyu Zhang Jiajia Chen 6 Shaoyan Hu 4 Bairong Shen Center for Systems Biology, Soochow University, Suzhou, 215006, China 2 Taicang Translational Bioinformatics, 215400, The 100 th Hospital of PLA, Suzhou 215007, Department Hematology and Oncology, Children's 215003, Pediatrics, First People's Lianyungang, Jiangsu 222002, School Chemistry, Biology Material Engineering, University Science Technology, 215011, Correspondence to:...