A5005579423- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Peroxisome Proliferator-Activated Receptors
- Immunotherapy and Immune Responses
- Extracellular vesicles in disease
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- RNA modifications and cancer
- T-cell and B-cell Immunology
- Cancer, Lipids, and Metabolism
- CRISPR and Genetic Engineering
- Ferroptosis and cancer prognosis
- Occupational and environmental lung diseases
- RNA Interference and Gene Delivery
- Monoclonal and Polyclonal Antibodies Research
- Inflammasome and immune disorders
- Cytomegalovirus and herpesvirus research
- Angiogenesis and VEGF in Cancer
- Cancer, Hypoxia, and Metabolism
- RNA and protein synthesis mechanisms
- NF-κB Signaling Pathways
- Aluminum toxicity and tolerance in plants and animals
- Lung Cancer Research Studies
- Wound Healing and Treatments
Xinxiang Medical University
2020-2025
Henan Provincial People's Hospital
2025
Henan University
2025
Central South University
2021-2024
First Affiliated Hospital of Henan University
2024
Xiangya Hospital Central South University
2021-2024
Hunan Cancer Hospital
2023
State Key Laboratory of Pharmaceutical Biotechnology
2017
Model Animal Research Center
2014-2017
Nanjing University
2014-2017
Abstract Tumor-associated macrophages are increasingly viewed as a target of great relevance in the tumor microenvironment, because their important role cancer progression and metastasis. However, endogenous regulatory mechanisms underlying tumor-associated macrophage differentiation remain largely unknown. Here, we report that caspase-1 promotes by cleaving peroxisome proliferator-activated receptor gamma (PPARγ) at Asp64, thus generating 41 kDa fragment. This truncated PPARγ translocates...
Preliminary results and emerging data have shown that lipid droplet high (LDhi ) immunosuppressive cells accumulate in tumour tissues. By tracking phenotypic profiling of LDhi cells, we find CD19+ , CD11b+ Ly6G+ immune cell populations appear the spleen, thymus, tissues a syngeneic model. Using contact-dependent reporter system, discover CCR7hi population migrates from to spleen thymus. Hence, engineered family chimeric antigen receptor-modified macrophages (CAR-Ms) direct CCR7-positive show...
Abstract Background Chronic inflammation and fibrosis are characteristics of silicosis, the inflammatory mediators involved in silicosis have not been fully elucidated. Recently, macrophage-derived exosomes reported to be modulators, but their role has explored. The purpose present study was investigate exosomal high mobility group box 3 (HMGB3) silica-induced pulmonary inflammation. Methods induction response recruitment monocytes/macrophages were evaluated by immunofluorescence, flow...
Chimeric antigen receptor (CAR) engineered natural killer (NK) cells have shown their efficacy and superiority against cancer possess the potential to become off-the-shelf immunotherapy products. Nonetheless, some challenges associated with CAR-NK still exist including inhibitory engagement, escape, inadequate activation. Given this, based on concept of synthetic biology, we rationally designed a novel dual-targeted CAR (dtCAR), primarily comprising PD-L1 nanoantibody (PD-L1Nb) NKG2D as...
Macrophages play a key role in silicosis, and exosomes are potent mediators of intercellular communication. This suggests that macrophage-derived have potential contribution to the pathogenesis silicosis. To investigate whether promote or inhibit lung fibrosis, vitro, silica-exposed (SiO
Breast cancer (BRCA) is the most common tumor in women, and lipid metabolism involvement has been demonstrated its tumorigenesis development. However, role of metabolism-associated genes (LMAGs) immune microenvironment prognosis BRCA remains unclear.A total 1076 patients with were extracted from The Cancer Genome Atlas database randomly assigned to training cohort (n = 760) or validation 316). Kaplan-Meier analysis was used assess differences survival. Consensus clustering performed...
<title>Abstract</title> Currently, given variations in the abnormal tumor microenvironment (TME), significant progress has been made treatment of breast cancer (BC) based on TME-responsive nanosystems-mediated ferroptosis. Actually, due to inherent deficiencies such as limited efficacy Fe-induced catalysis, lack endogenous hydrogen peroxide (H2O2), and overexpression glutathione (GSH) cells, ferroptosis is restricted. Here, this document highlighted polymeric nanoparticles with GSH resection...
Abstract Diabetic foot ulcers (DFUs) are a complex mixture of neuropathy, peripheral arterial disease, and infection, where excessive reactive oxygen species (ROS) exacerbates inflammation impairs healing. Therefore, there is an urgent need to design hydrogel dressing with ‘lever’ function balance ROS levels in the wound achieve both antimicrobial anti‐inflammatory effects on DFUs. In this study, we synthesised ROS‐responsive diselenide liposomes loaded pro‐skin healing factor (ergothioneine...
Monocyte-to-macrophage differentiation is tightly controlled in vivo, as disruption of the normal program can lead to diverse disorders. Caspase-1, first identified member caspase family, regulates various cell types such Th17 cells and adipocytes. However, contribution caspase-1 monocyte-macrophage remains elusive. Here we report that significantly downregulated leukemia from patients with acute monocytic leukemia. By using phorbol 12-myristate 13-acetate-induced model, found activation was...
Abstract The human-derived NK-92 cell–based CAR-NK therapy exhibits inconsistency with overall suboptimal efficacy and rapid in vivo clearance of CAR-NK92 cells cancer patients. Analysis indicates that although pre-existing IgM healthy individuals (n = 10) strongly recognizes both cells, IgG IgE do not. However, only a subset patients (3/8) exhibit strong recognition these some (2/8) showing recognition. These results suggest natural immunoreactivity between human Abs. Furthermore, the...