A5088066446- Diet and metabolism studies
- Gut microbiota and health
- Advanced Glycation End Products research
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Chronic Kidney Disease and Diabetes
- Inflammasome and immune disorders
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Autophagy in Disease and Therapy
- Neuroinflammation and Neurodegeneration Mechanisms
- Streptococcal Infections and Treatments
- Biological and pharmacological studies of plants
- Ginger and Zingiberaceae research
- Pancreatic function and diabetes
- Antimicrobial Resistance in Staphylococcus
- Liver physiology and pathology
- Tryptophan and brain disorders
- Renal Diseases and Glomerulopathies
- Mitochondrial Function and Pathology
- Sirtuins and Resveratrol in Medicine
- Atherosclerosis and Cardiovascular Diseases
- DNA Repair Mechanisms
- PARP inhibition in cancer therapy
- Adipose Tissue and Metabolism
Beijing University of Chinese Medicine
2024-2025
Shantou University
2024-2025
Shenzhen Children's Hospital
2024-2025
Shantou University Medical College
2024-2025
Ruijin Hospital
2025
Shanghai Jiao Tong University
2025
Fujian University of Traditional Chinese Medicine
2020-2024
Sun Yat-sen Memorial Hospital
2024
Sun Yat-sen University
2024
Dendrobium mixture (DM) is a patent Chinese herbal formulation consisting of Dendrobii Caulis, Astragali Radix, Rehmanniae Radix as the main ingredients. DM has been shown to alleviate diabetic related symptoms attributed its anti-hyperglycaemic and anti-inflammatory activities. However, effect on induced cognitive dysfunction not investigated. This study aims investigate in improving impairment associated mechanisms. Our confirmed showed capacity restore memory function high fat/high...
Poly(ADP-ribosyl)ation (PARylation) is a critical posttranslational modification that plays vital role in maintaining genomic stability via variety of molecular mechanisms, including activation replication stress and the DNA damage response. The nudix hydrolase NUDT16 was recently identified as phosphodiesterase responsible for removing ADP-ribose units an important repair. However, roles coordinating cell cycle progression remain elusive. Here, we report SETD3, which member SET-domain...
<title>Abstract</title> Currently, given variations in the abnormal tumor microenvironment (TME), significant progress has been made treatment of breast cancer (BC) based on TME-responsive nanosystems-mediated ferroptosis. Actually, due to inherent deficiencies such as limited efficacy Fe-induced catalysis, lack endogenous hydrogen peroxide (H2O2), and overexpression glutathione (GSH) cells, ferroptosis is restricted. Here, this document highlighted polymeric nanoparticles with GSH resection...
Diabetes-induced cognitive impairment (DCI) presents a major public health risk among the aging population. Previous clinical attempts on known therapeutic targets for DCI, such as depleted insulin secretion, resistance, and hyperglycaemia have delivered poor patient outcomes. However, recent evidence has demonstrated that gut microbiome plays an important role in DCI by modulating function through gut-brain crosstalk. The bioactive compound tanshinone IIA (TAN) shown to improve memory...
Background. Diabetic keratopathy (DK) poses a significant challenge in diabetes mellitus, yet its molecular pathways and effective treatments remain elusive. The aim of our research was to explore the pyroptosis-related genes corneal epithelium streptozocin-induced diabetic rats. Methods. After sixteen weeks streptozocin intraperitoneal injection, from three rats normal groups underwent whole-transcriptome sequencing. An integrated bioinformatics pipeline, including differentially expressed...
Dendrobium mixture (DM) is a patented Chinese herbal medicine which has been shown to ameliorate type 2 diabetes mellitus (T2DM) with non-alcoholic fatty liver disease (NAFLD) in vivo and vitro. We aimed investigate the underlying mechanism of DM as therapeutic agent attenuating steatosis relation (T2DM). (16.2 g/kg/d) was administered db/db mice for 4 weeks. The db/m control model groups were given normal saline. Additionally, (11.25 Sprague-Dawley (SD) rats, serum collected used an...
Ferroptosis is extremely relevant to the progression of neurodegenerative pathologies such as Alzheimer's disease (AD). Ubiquitin-specific proteases (USP) can affect NADPH oxidase family.
To observe the effects of electroacupuncture (EA) on expression serum interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and pancreatic nuclear factor-κB (NF-κB) pathway in type 2 diabetes mellitus (T2DM) rats, to explore possible mechanism by which EA improving dedifferentiation β-cells treatment T2DM.
Dendrobium mixture (DM) is a patented Chinese herbal medicine indicated which has anti-inflammatory and improved glycolipid metabolism. However, its active ingredients, targets of action, potential mechanisms are still uncertain. Here, we investigate the role DM as prospective modulator protection against non-alcoholic fatty liver disease (NAFLD) induced by type 2 diabetes mellitus (T2DM) illustrate molecular potentially involved. The network pharmacology TMT-based quantitative protomics...
Yu Nu compound (YNJ) is a traditional Chinese medicine widely utilized to treat type 2 diabetes possibly through mediating autophagy. Abnormal podocyte autophagy and apoptosis could result in loss diabetics nephropathy (DN). The mechanism of DN still unclear. Therefore, the study aims investigate effects analyze potential mechanism.Goto-Kakizaki (GK) rats were administered using YNJ with different doses once day by gavage for 4 weeks. renal cortex injury was observed HE staining electron...
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<title>Abstract</title> <bold>Background: </bold>Recent studies havehighlighted type 2 diabetes (T2DM) as a significant risk factor for the development of metabolic dysfunction-associated fatty liver disease (MAFLD). This investigation aimed to assess electroacupuncture's (EA) impact on morphology and function in T2DM rats, furnishing experimental substantiation its potential stall MAFLD progression T2DM. <bold>Methods:</bold> rats were induced by high-fat diet single intraperitoneal...
Abstract Background: Yu Nu compound (YNJ) is a traditional Chinese medicine widely utilized to treat type 2 diebetes, which has been reported regulate autophagy. Abnormal podocyte autophagy and apoptosis could result in loss diabetics nephropathy (DN). The mechanism of DN still unclear. Therefore, the study aims investigate how exerts effects on rats.Methods: GK rats were administered using YNJ with different dose once day by gavage for 4 weeks. renal cortex injury was observed HE electron...