A5016633560- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Angiogenesis and VEGF in Cancer
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Liver physiology and pathology
- Genomics and Phylogenetic Studies
- Cancer Immunotherapy and Biomarkers
- Lymphatic System and Diseases
- Microbial Community Ecology and Physiology
- Immune cells in cancer
- MicroRNA in disease regulation
- CRISPR and Genetic Engineering
- Monoclonal and Polyclonal Antibodies Research
- Identification and Quantification in Food
- Cytomegalovirus and herpesvirus research
- Glycosylation and Glycoproteins Research
- Protease and Inhibitor Mechanisms
- Axon Guidance and Neuronal Signaling
- Circular RNAs in diseases
- RNA Interference and Gene Delivery
- RNA and protein synthesis mechanisms
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Salivary Gland Disorders and Functions
Xinxiang Medical University
2016-2025
First Affiliated Hospital of Xinxiang Medical University
2021
Gaozhou People's Hospital
2020
University of Science and Technology of China
2020
Zhengzhou University
2003
Preliminary results and emerging data have shown that lipid droplet high (LDhi ) immunosuppressive cells accumulate in tumour tissues. By tracking phenotypic profiling of LDhi cells, we find CD19+ , CD11b+ Ly6G+ immune cell populations appear the spleen, thymus, tissues a syngeneic model. Using contact-dependent reporter system, discover CCR7hi population migrates from to spleen thymus. Hence, engineered family chimeric antigen receptor-modified macrophages (CAR-Ms) direct CCR7-positive show...
Chimeric antigen receptor (CAR) engineered natural killer (NK) cells have shown their efficacy and superiority against cancer possess the potential to become off-the-shelf immunotherapy products. Nonetheless, some challenges associated with CAR-NK still exist including inhibitory engagement, escape, inadequate activation. Given this, based on concept of synthetic biology, we rationally designed a novel dual-targeted CAR (dtCAR), primarily comprising PD-L1 nanoantibody (PD-L1Nb) NKG2D as...
Use of chimeric antigen receptors (CARs), as an immune cell therapy, has generated excellent clinical outcomes against hematologic tumors in recent years. Among them, the CAR-NK (natural killer) therapy shown better efficacy, and less toxicity, than receptor T-cell (CAR-T) therapy. In our phase II trials, administering costimulatory converting (CCCR)-NK92 cells on advanced non-small lung cancer patients proved efficacious animal experiments. However, we observed occurrence cytokine release...
Based on our previous work the PLGA nanoparticles modified with biotinylated chitosan (Bio-CS-PLGA NPs), we further studied stability, toxicity, pharmacokinetics, and in vivo efficacy. The safety of NPs was through single-dose toxicity test mice, result showed that were well tolerated at dose 300 mg/kg. Compared free EPB group, group exhibited higher plasma drug concentration, longer half-life time. EPB-loaded significantly inhibited tumor growth compared to EPB. All results suggested...
A novel Gram-stain-negative, straight or slightly curved rod-shaped, non-spore-forming, non-flagellated, strictly aerobic strain, designated RZG4-3-1T, was isolated from coastal seawater of Rizhao, China (119.625° E 35.517° N). The organism grew optimally at 24–28 °C, pH 7.0 and in the presence 2.0 % (w/v) NaCl. strain required artificial for growth, NaCl alone did not support growth. Strain RZG4-3-1T contained ubiquinone 8 (Q-8) as major respiratory quinone C16 : 1 ω7c and/or ω6c 0 dominant...
A novel Gram-stain-negative, rod-shaped, non-spore-forming, non-flagellated, strictly aerobic strain, designated RZW3-2T, was isolated from seawater near the Yellow Sea coast of PR China (35.475° N 119.613° E). The organism grew optimally between 24 and 28 °C, at pH 6.0–7.0 in presence 2–3 % (w/v) NaCl. strain requires or artificial for growth NaCl alone does not support growth. RZW3-2T contained iso-C15 : 0, C16 1ω7c and/or 1ω6c anteiso-C15 0 as dominant fatty acids. respiratory quinone...
Abstract The human-derived NK-92 cell–based CAR-NK therapy exhibits inconsistency with overall suboptimal efficacy and rapid in vivo clearance of CAR-NK92 cells cancer patients. Analysis indicates that although pre-existing IgM healthy individuals (n = 10) strongly recognizes both cells, IgG IgE do not. However, only a subset patients (3/8) exhibit strong recognition these some (2/8) showing recognition. These results suggest natural immunoreactivity between human Abs. Furthermore, the...
A novel Gram-stain-negative, rod-shaped, non-spore-forming, non-flagellated, strictly aerobic strain, designated A6024T, was isolated from coastal seawater near Rizhao, PR China (119.61° E 35.47° N). The organism grew optimally at 28 °C, in pH 6.0-7.0 and the presence of 3.0 % (w/v) NaCl. strain required or artificial for growth NaCl alone did not support growth. Strain A6024T contained ubiquinone 10 as sole respiratory quinone C18 : 1ω7c (75.2 %) most abundant fatty acid. predominant polar...
A novel bacterial strain, C3212