A5050768916- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- RNA Research and Splicing
- Autoimmune Neurological Disorders and Treatments
- Alzheimer's disease research and treatments
- Tryptophan and brain disorders
- MRI in cancer diagnosis
- Neuropeptides and Animal Physiology
- RNA regulation and disease
- Amino Acid Enzymes and Metabolism
- Glioma Diagnosis and Treatment
- Ophthalmology and Eye Disorders
- Inflammatory Myopathies and Dermatomyositis
- PI3K/AKT/mTOR signaling in cancer
- RNA Interference and Gene Delivery
- FOXO transcription factor regulation
- Reproductive System and Pregnancy
- Cancer Mechanisms and Therapy
- Ferroptosis and cancer prognosis
- Signaling Pathways in Disease
- Systemic Lupus Erythematosus Research
- Integrated Energy Systems Optimization
- Neurological diseases and metabolism
Guangzhou Medical University
2024-2025
The First Affiliated Hospital, Sun Yat-sen University
2016-2025
Sun Yat-sen University
2016-2025
Henan Provincial People's Hospital
2018-2025
Guangzhou Women and Children Medical Center
2024
Zhengzhou University
2018-2024
First Affiliated Hospital of Zhengzhou University
2017-2022
China University of Geosciences
2019
Key Laboratory of Guangdong Province
2017-2018
Nanjing Drum Tower Hospital
2017
Circular RNAs (circRNAs) are RNA transcripts that widespread in the eukaryotic genome. Recent evidence indicates circRNAs play important roles tissue development, gene regulation, and carcinogenesis. However, whether encode functional proteins remains elusive, although translation of several was recently reported. CircRNA deep sequencing performed by using 10 pathologically diagnosed glioblastoma samples their paired adjacent normal brain tissues. Northern blotting, Sanger sequencing,...
Abstract Cuproptosis, a recently defined copper‐dependent cell death pathway, remains largely unexplored in tumor therapies, particularly breast cancer. This study demonstrates that triple‐negative cancer (TNBC) bears relatively elevated copper levels and exhibits resistance to cuproptosis. Mechanistically, activates the AKT signaling which inhibits ferredoxin‐1 (FDX1), key regulator of AKT1‐mediated FDX1 phosphorylation not only abrogates FDX1‐induced cuproptosis aerobic respiration but...
Emerging studies have revealed the potent functions of circRNAs in breast cancer tumorigenesis. However, biogenesis, biofunction and mechanism triple-negative (TNBC) are largely unknown.High-throughput RNA sequencing was applied to identify dysregulated TNBCs paired normal tissues. pulldown luciferase assays were performed investigate interaction between circular CD44 (circCD44, also annotated as hsa_circ_0021735) miR-502-5p. RIP used circCD44 IGF2BP2. Cell viability, colony formation,...
Abstract Glioblastoma (GBM) is a highly aggressive primary brain tumour and resistant to nearly all available treatments, including natural killer (NK) cell immunotherapy. However, the factors mediating NK evasion in GBM remain largely unclear. Here, we report that EZH2-92aa, protein encoded by circular EZH2, overexpressed induces immune of stem cells (GSCs) from cells. Positively regulated DEAD-box helicase 3 (DDX3), EZH2-92aa directly binds major histocompatibility complex class I...
Abstract Mutations of the RAS oncogene are found in around 30% all human cancers yet direct targeting is still considered clinically impractical except for KRAS G12C mutant. Here we report that - ON (RASON), a novel protein encoded by long intergenic non-protein coding RNA 00673 ( LINC00673 ), positive regulator oncogenic signaling. RASON aberrantly overexpressed pancreatic ductal adenocarcinoma (PDAC) patients, and it promotes proliferation PDAC cell lines vitro tumor growth vivo....
Accumulating studies indicate that circular RNAs (circRNAs) play critical roles in cancer progression. Most of them have been reported to act as microRNA sponges or interact with RNA-binding proteins; however, their full range functions remains largely unclear. Recently, an increasing number circRNAs found encode proteins. C-E-Cad, a protein encoded by E-cadherin (circ-E-Cad), has shown great influence the progression glioblastoma, but its specific role gastric (GC) is Here, we both...
We previously demonstrated that the C-E-cad protein encoded by circ-E-cadherin promotes self-renewal of glioma stem cells. The expression pattern in breast cancer and its potential function tumor microenvironment are unclear. was detected specimens. influence on MDSCs assessed using FACS vivo tumorigenesis experiments. synergistic effect anti-C-E-cad anti-PD-1 antibodies validated vivo. were found to be upregulated vs. normal samples. recruitment MDSCs, especially PMN-MDSCs. activates EGFR...
MYC promotes tumor growth through multiple mechanisms. Here, we show that, in human glioblastomas, the variant transcript encodes a 114–amino acid peptide, pre-mRNA encoded protein (MPEP), from upstream open reading frame (uORF) MPEP . Secreted patient-derived xenograft vivo, independent of direct binding, and activation tropomyosin receptor kinase B (TRKB), which induces downstream AKT-mTOR signaling. Targeting genetic ablation reduced 4121 3691 glioblastoma stem cells. Administration an...
Abstract Lipid metabolism reprogram plays key roles in breast cancer tumorigenesis and immune escape. The underlying mechanism potential regulator were barely investigated. We thus established an vivo model, mice-bearing cells treated with ordinary diet high-fat diet, species collected subjected to circRNA sequence scan the circRNAs regulating lipid metabolism. CircSpdyA was one of most upregulated had encode a 127-aa micro peptide (referred as 127aa). 127 aa promotes through promoting fatty...
Early life experience modulates resilience to stress in later life. Previous research implicated maternal care as a key mediator of behavioral responses the adversity adolescence, but details molecular mechanisms remain elusive. Here, we show social activates transcription factor C/EBPβ mPFC neurons adolescent mice, which transcriptionally upregulates Dnm1l and promotes mitochondrial dysfunction, thereby conferring susceptibility mice. Moreover, different separation differentially regulates...
Abstract Macrophages play vital roles in innate and adaptive immunity, their essential functions are mediated by phagocytosis antigen presentation. Long non‐coding ribonucleic acid nuclear enriched abundant transcript 1 ( LincNEAT1 ) is specifically translated during phagocytosis. Great efforts have been made to explore the potential mechanisms of action these phagocytic checkpoints. However, use a systematic checkpoint scanning strategy has far from satisfactory, intrinsic activators not...
Forkhead box M1 (FOXM1) is overexpressed and activates numerous oncoproteins in tumors. However, the mechanism by which FOXM1 protein aberrantly accumulates human cancer remains uncertain. This study was designed to clarify upstream signaling pathway(s) that regulate stability transcriptional activity.Mass spectrometry immunoprecipitation were performed identify FOXM-metadherin (MTDH) interaction. In vivo vitro ubiquitination assays conducted test effect of MTDH on stability. Chromatin used...
Cancer stem cells (CSCs) are defined as a rare subpopulation of undifferentiated with biological characteristics that include the capacity for self-renewal, differentiation into various lineages, and tumor initiation. To explore mechanism CSCs in esophageal squamous cell carcinoma (ESCC), we focused on Leucine-rich repeat containing G protein-coupled receptor 5 (Lgr5), target gene Wnt signaling pathway, which has been identified marker intestinal shown to be overexpressed several human...
Background: RP11-480I12.5 is a newly identified long noncoding RNA (lncRNA) that has never been studied in breast cancer. The biological function of carcinoma and its underlying mechanism are still unknown. Methods: We scanned the Cancer Genome Atlas (TCGA) database as one most dysregulated lncRNAs. level was assessed cancer (BC) tissue samples BC cell lines. prognostic value expression using Kaplan-Meier method. influence on lines proliferation, Transwell migration, invasion assays....
Alzheimer's disease (AD) is the most prevalent neurodegenerative characterized by extracellular senile plaques including amyloid-β peptides and intracellular neurofibrillary tangles consisting of abnormal Tau. Depression one common neuropsychiatric symptoms in AD, clinical evidence demonstrates that depressive accelerate cognitive deficit AD patients. However, underlying molecular mechanisms present process remain unclear.Depressive-like behaviors decline hTau mice were induced chronic...
Objective To explore the clinical significance of expressing multiple autoantibodies in patients with autoimmune encephalitis. Methods Cerebrospinal fluid and serum were tested undefined encephalitis admitted to Peking Union Medical College Hospital from May 2013 December 2014. Indirect immunofluorescence test was firstly used identify antibodies neuronal cell-surface or synaptic receptors (including N-methyl-D-aspartate receptor (NMDAR), contactin-associated protein-like 2 (CASPR2),...